{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,24]],"date-time":"2026-06-24T09:48:51Z","timestamp":1782294531252,"version":"3.54.5"},"reference-count":33,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2026,4,7]],"date-time":"2026-04-07T00:00:00Z","timestamp":1775520000000},"content-version":"vor","delay-in-days":6,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,4,1]],"date-time":"2026-04-01T00:00:00Z","timestamp":1775001600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Cosmetic Dermatology"],"published-print":{"date-parts":[[2026,4]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Ascorbic acid (AA) has protective and corrective functions critical for counteracting extrinsic and intrinsic skin aging and hyperpigmentation, but it is highly unstable, making it challenging to formulate into skincare products. Tetrahexyldecyl (THD) Ascorbate, a lipid\u2010soluble derivative of AA, has superior stability and skin\u2010mimicking properties.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Aims<\/jats:title>\n                    <jats:p>To investigate the efficacy and tolerability of a novel antioxidant serum containing 30% THD Ascorbate (THD\u2010AA serum), a patent\u2010pending blend of antioxidants and prebiotics, on photoaged and hyperpigmented skin with respect to long\u2010term skin health.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Using preclinical models and a randomized, double\u2010blind clinical trial, the antioxidant potential, antimelanogenesis, and antiaging properties of the THD\u2010AA serum were evaluated.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Using an in\u00a0vitro tissue model exposed to blue light, there was an 88% reduction in reactive oxygen species (ROS) formation after 30\u2009min, 87% reduction after 60\u2009min, and an 82% reduction after 120\u2009min compared to the blue light\u2010exposed control. Melanin production was reduced by 24% in\u00a0vitro tissue co\u2010culture. THD\u2010AA serum improved the structural architecture of the skin, including the epidermis, dermal\u2010epidermal junction, and dermis, and upregulated dermal collagen production 4\u2010fold compared to a controlled moisturizer in an ex\u00a0vivo model. In the clinical trial, existing damage and hyperpigmentation were visibly corrected on VISIA\u2010CR and Antera 3D photographs, as well as in Clinical Grader results. There were no adverse events, and participants tolerated the serum well.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>THD\u2010AA serum has clinical and molecular efficacy in buffering ROS, reducing melanogenesis, and promoting antiaging, providing a safe alternative to hydroquinone products.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/jocd.70826","type":"journal-article","created":{"date-parts":[[2026,4,8]],"date-time":"2026-04-08T05:41:57Z","timestamp":1775626917000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Hydroquinone\u2010Free, Tetrahexyldecyl Ascorbate Antioxidant Serum for Hyperpigmented and Photodamaged Skin to Achieve Skin Health"],"prefix":"10.1111","volume":"25","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1621-6458","authenticated-orcid":false,"given":"McKenzie E.","family":"Maloney","sequence":"first","affiliation":[{"name":"Department of Internal Medicine Massachusetts General Hospital  Boston Massachusetts USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"May","family":"Hall","sequence":"additional","affiliation":[{"name":"Advanced Dermatology and Skin Surgery  Asheville North Carolina USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0774-649X","authenticated-orcid":false,"given":"Ryan C.","family":"Kelm","sequence":"additional","affiliation":[{"name":"Clinic 5C  Spokane Washington USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tatiana","family":"Kononov","sequence":"additional","affiliation":[{"name":"Revision Skincare\u00e2  Irving Texas USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6964-0776","authenticated-orcid":false,"given":"Alisar","family":"Zahr","sequence":"additional","affiliation":[{"name":"Revision Skincare\u00e2  Irving Texas USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,4,7]]},"reference":[{"key":"e_1_2_13_2_1","doi-asserted-by":"publisher","DOI":"10.1055\/s\u20100034\u20101365824"},{"key":"e_1_2_13_3_1","doi-asserted-by":"publisher","DOI":"10.1001\/archderm.131.12.1453"},{"key":"e_1_2_13_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaad.2017.01.035"},{"key":"e_1_2_13_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/exd.13844"},{"key":"e_1_2_13_6_1","volume-title":"Administration USFD, Ed. 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