{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,24]],"date-time":"2026-06-24T09:48:31Z","timestamp":1782294511640,"version":"3.54.5"},"reference-count":13,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2026,4,8]],"date-time":"2026-04-08T00:00:00Z","timestamp":1775606400000},"content-version":"vor","delay-in-days":7,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,4,1]],"date-time":"2026-04-01T00:00:00Z","timestamp":1775001600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Cosmetic Dermatology"],"published-print":{"date-parts":[[2026,4]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Current acne management relies largely on topical and systemic pharmacotherapy, but these treatments frequently cause cutaneous adverse reactions. Such side effects are of particular concern in patients with initial skin sensitivity, highlighting the need for personalized approaches.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      This 12\u2010week prospective observational study included 308 Korean acne patients to compare the clinical efficacy of a specific dermo\u2010cosmetic (DC) formulation used as monotherapy versus combination therapy in acne patients, and to evaluate a sensitivity\u2010based approach to improve quality of life. Patients were classified into DC monotherapy (\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u2009151) or combination therapy (\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u2009157), and to sensitive (\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u2009144) or non\u2010sensitive (\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u2009164) subgroups. Primary outcomes were Global Evaluation of Acne (GEA), total lesion count, and sebum secretion levels. Secondary outcomes included skin sensitization score, tolerance assessment, quality of life, and adverse events.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      The DC monotherapy group showed significantly greater improvement in GEA scores, fewer sensitivity symptoms, improved quality of life, and greater tolerability than the combination therapy group (all\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.0001). In the sensitive patient subgroup, DC monotherapy was also significantly superior to combination therapy in terms of GEA, tolerability, sensitivity symptoms, and quality of life (all\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.0001). In patients without initial sensitivity, improvement in GEA (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.0079), total lesion count (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.0001), and sebum secretion (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.0001) was significantly greater in the combination therapy than in the DC monotherapy.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>These findings suggest that baseline skin sensitivity may represent an important determinant of treatment selection and support a sensitivity\u2010guided personalized treatment approach in acne management.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/jocd.70831","type":"journal-article","created":{"date-parts":[[2026,4,8]],"date-time":"2026-04-08T12:10:16Z","timestamp":1775650216000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Personalized Approach for Acne Management With Dermocosmetics According to Initial Skin Sensitivity"],"prefix":"10.1111","volume":"25","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3194-5202","authenticated-orcid":false,"given":"Ju Hee","family":"Han","sequence":"first","affiliation":[{"name":"Department of Dermatology, College of Medicine The Catholic University of Korea  Seoul Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hyun Jeong","family":"Ju","sequence":"additional","affiliation":[{"name":"Department of Dermatology, College of Medicine The Catholic University of Korea  Seoul Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tae In","family":"Kim","sequence":"additional","affiliation":[{"name":"Dermatology Doctors Dermatology Clinic  Seoul Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Young Hoon","family":"Yoon","sequence":"additional","affiliation":[{"name":"Dermatology The Yoon Dermatologic Clinic  Seoul Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Young Jun","family":"Woo","sequence":"additional","affiliation":[{"name":"Dermatology The Mimodern Dermatologic Clinic  Seoul Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Heesang","family":"Kye","sequence":"additional","affiliation":[{"name":"Dermatology KYE\u2010Skin Clinic  Seoul Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jong Yeob","family":"Kim","sequence":"additional","affiliation":[{"name":"Dermatology Timeless Dermatologic Clinic  Seoul Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Su Jin","family":"Jeong","sequence":"additional","affiliation":[{"name":"Statistics Support Part, Medical Science Research Institute Kyung Hee University  Seoul Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eunsun","family":"Baek","sequence":"additional","affiliation":[{"name":"Medical Affairs, La Roche Posay, Loreal Dermatological Beauty L'Or\u00e9al Korea Ltd.  Seoul Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5975-8519","authenticated-orcid":false,"given":"Jung Min","family":"Bae","sequence":"additional","affiliation":[{"name":"Department of Dermatology, College of Medicine The Catholic University of Korea  Seoul Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,4,8]]},"reference":[{"key":"e_1_2_13_2_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrdp.2015.29"},{"key":"e_1_2_13_3_1","doi-asserted-by":"publisher","DOI":"10.1093\/bjd\/ljae352"},{"key":"e_1_2_13_4_1","doi-asserted-by":"publisher","DOI":"10.7573\/dic.2021-8-6"},{"key":"e_1_2_13_5_1","doi-asserted-by":"publisher","DOI":"10.1007\/s40257-025-00983-3"},{"key":"e_1_2_13_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/jocd.16772"},{"key":"e_1_2_13_7_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms25105302"},{"key":"e_1_2_13_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbrep.2023.101578"},{"key":"e_1_2_13_9_1","doi-asserted-by":"publisher","DOI":"10.3390\/jcm11247535"},{"key":"e_1_2_13_10_1","doi-asserted-by":"publisher","DOI":"10.1111\/ijd.17546"},{"key":"e_1_2_13_11_1","doi-asserted-by":"publisher","DOI":"10.1111\/jdv.13579"},{"key":"e_1_2_13_12_1","doi-asserted-by":"publisher","DOI":"10.1111\/jocd.70297"},{"key":"e_1_2_13_13_1","doi-asserted-by":"publisher","DOI":"10.3390\/cosmetics11060220"},{"key":"e_1_2_13_14_1","doi-asserted-by":"publisher","DOI":"10.2147\/CCID.S533950"}],"container-title":["Journal of Cosmetic Dermatology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/jocd.70831","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/jocd.70831","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/jocd.70831","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,6,24]],"date-time":"2026-06-24T09:23:37Z","timestamp":1782293017000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/jocd.70831"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,4]]},"references-count":13,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2026,4]]}},"alternative-id":["10.1111\/jocd.70831"],"URL":"https:\/\/doi.org\/10.1111\/jocd.70831","archive":["Portico"],"relation":{},"ISSN":["1473-2130","1473-2165"],"issn-type":[{"value":"1473-2130","type":"print"},{"value":"1473-2165","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,4]]},"assertion":[{"value":"2025-12-04","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-03-23","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-04-08","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e70831"}}