{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,24]],"date-time":"2026-06-24T09:48:35Z","timestamp":1782294515685,"version":"3.54.5"},"reference-count":46,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2026,4,7]],"date-time":"2026-04-07T00:00:00Z","timestamp":1775520000000},"content-version":"vor","delay-in-days":6,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,4,1]],"date-time":"2026-04-01T00:00:00Z","timestamp":1775001600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Cosmetic Dermatology"],"published-print":{"date-parts":[[2026,4]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Photoaged skin is primarily induced by prolonged exposure to ultraviolet radiation, leading to increased pigmentation, reduced elasticity, and pronounced wrinkles. There has been an increasing recognition of the influence of nutrition on skin health, with dietary elements emerging as a viable alternative approach to preventing photoaging. This study explores how oral supplementation impacts photoaged skin, hydration, and elasticity.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Aims<\/jats:title>\n                    <jats:p>This study evaluates the effects of an antioxidant\u2010rich synbiotic supplement on facial elasticity, hydration, and photoaging markers, such as erythema and pigmentation.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Patients\/Methods<\/jats:title>\n                    <jats:p>In this 8\u2010week study, 36 participants from the Sacramento region were randomized to receive either the antioxidant\u2010rich synbiotic supplement or a placebo. Participants had 3 visits: baseline, week 4, and week 8. Noninvasive facial measurements, including hydration, elasticity, erythema, and pigmentation, were obtained. Facial photography and analysis were performed. Tolerability was assessed.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      At week 8, the treatment group showed a significant reduction in wrinkle severity (\u22125.28%,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.01), whereas the placebo group did not. Cheek elasticity increased significantly at week 4 (22.0%,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.01) and week 8 (13.8%,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.05), along with firmness at week 8 (12.2%,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.01). The placebo group showed no significant changes in these parameters. Additionally, the viscoelasticity of the cheek increased at week 4 (30.2%,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.01) in the treatment group, with no change in the placebo group.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>The antioxidant\u2010rich synbiotic supplement improved wrinkle severity, skin facial elasticity, and skin firmness, enhancing several parameters of photoaging.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/jocd.70836","type":"journal-article","created":{"date-parts":[[2026,4,8]],"date-time":"2026-04-08T05:40:17Z","timestamp":1775626817000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Prospective, Randomized, Double\u2010Blind, Placebo\u2010Controlled Study of an Oral Antioxidant\u2010Rich Synbiotic Supplement on Skin Health and Photoaging"],"prefix":"10.1111","volume":"25","author":[{"given":"Laila","family":"Afzal","sequence":"first","affiliation":[{"name":"Integrative Skin Science and Research  Sacramento California USA"},{"name":"Integraive Research Institute  Sacramento California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nhi","family":"Nguyen","sequence":"additional","affiliation":[{"name":"Integrative Skin Science and Research  Sacramento California USA"},{"name":"Integraive Research Institute  Sacramento California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nasima","family":"Afzal","sequence":"additional","affiliation":[{"name":"Integrative Skin Science and Research  Sacramento California USA"},{"name":"Integraive Research Institute  Sacramento California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sarah","family":"Adnan","sequence":"additional","affiliation":[{"name":"Integrative Skin Science and Research  Sacramento California USA"},{"name":"Integraive Research Institute  Sacramento California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zillehuma","family":"Khan","sequence":"additional","affiliation":[{"name":"Integraive Research Institute  Sacramento California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0000-2045-1819","authenticated-orcid":false,"given":"Ajay S.","family":"Dulai","sequence":"additional","affiliation":[{"name":"Integrative Skin Science and Research  Sacramento California USA"},{"name":"Integraive Research Institute  Sacramento California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Subhendu","family":"Nayak","sequence":"additional","affiliation":[{"name":"Vidya Herbs  Florida USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rishi R.","family":"Trivedi","sequence":"additional","affiliation":[{"name":"Vidya Herbs  Florida 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