{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,16]],"date-time":"2026-10-16T19:56:13Z","timestamp":1792180573683,"version":"4.4.0"},"reference-count":37,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2026,4,5]],"date-time":"2026-04-05T00:00:00Z","timestamp":1775347200000},"content-version":"vor","delay-in-days":4,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,4,1]],"date-time":"2026-04-01T00:00:00Z","timestamp":1775001600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81774440"],"award-info":[{"award-number":["81774440"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100018542","name":"Natural Science Foundation of Sichuan Province","doi-asserted-by":"publisher","award":["2024NSFSC0693"],"award-info":[{"award-number":["2024NSFSC0693"]}],"id":[{"id":"10.13039\/501100018542","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Cosmetic Dermatology"],"published-print":{"date-parts":[[2026,4]]},"abstract":"ABSTRACT<\/jats:title>\n \n Background<\/jats:title>\n Skin aging is a key focus in aesthetic and dermatologic medicine. Transcutaneous electrical acupoint stimulation (TEAS) is a noninvasive, acupuncture\u2010based technique that integrates traditional meridian theory with modern electrical stimulation. This study evaluated the clinical efficacy and safety of TEAS in improving the clinical signs of facial skin aging and promoting facial rejuvenation.<\/jats:p>\n <\/jats:sec>\n \n Objective<\/jats:title>\n This study aimed to evaluate the effects of TEAS on the clinical signs of facial skin aging.<\/jats:p>\n <\/jats:sec>\n \n Methods<\/jats:title>\n Ninety participants were randomly assigned to TEAS, acupuncture, or Sham\u2010TEAS groups. The TEAS group received 30\u2010min treatments, five times per week for four weeks. Primary and secondary outcomes were assessed using the VISIA analysis system and the FACE\u2010Q scale.<\/jats:p>\n <\/jats:sec>\n \n Results<\/jats:title>\n \n TEAS significantly reduced wrinkle scores at week 4 and week 8 compared with baseline (\n p<\/jats:italic>\n \u2009<\u20090.001) and achieved greater improvement than acupuncture (\n p<\/jats:italic>\n \u2009<\u20090.05). FACE\u2010Q scores increased significantly in the TEAS and acupuncture groups compared with Sham\u2010TEAS (\n p<\/jats:italic>\n \u2009<\u20090.01), with greater improvement in Social Function in the TEAS group (\n p<\/jats:italic>\n \u2009<\u20090.05). Both physician\u2010rated and self\u2010assessed GAIS and WSRS scores also improved in the TEAS group (\n p<\/jats:italic>\n \u2009<\u20090.001).\n <\/jats:p>\n <\/jats:sec>\n \n Conclusion<\/jats:title>\n TEAS appears to be a safe, noninvasive intervention that is primarily effective in reducing wrinkle severity and improving patient\u2010reported outcomes, while showing limited effects on other VISIA parameters of facial skin aging.<\/jats:p>\n <\/jats:sec>","DOI":"10.1111\/jocd.70839","type":"journal-article","created":{"date-parts":[[2026,4,6]],"date-time":"2026-04-06T03:20:37Z","timestamp":1775445637000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Efficacy and Safety of Transcutaneous Electrical Acupoint Stimulation for Improving Clinical Signs of Facial Skin Aging"],"prefix":"10.1111","volume":"25","author":[{"ORCID":"https:\/\/orcid.org\/0009-0009-1512-9548","authenticated-orcid":false,"given":"Yi","family":"Luo","sequence":"first","affiliation":[{"name":"College of Acupuncture and Tuina Chengdu University of Traditional Chinese Medicine Chengdu China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hai","family":"Yu","sequence":"additional","affiliation":[{"name":"College of Acupuncture and Tuina Chengdu University of Traditional Chinese Medicine Chengdu China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Linxin","family":"Pan","sequence":"additional","affiliation":[{"name":"Department of Dermatology People's Liberation Army General Hospital of Western Theater Command Chengdu China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chun","family":"Yang","sequence":"additional","affiliation":[{"name":"College of Acupuncture and Tuina Chengdu University of Traditional Chinese Medicine Chengdu China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jie","family":"Zhang","sequence":"additional","affiliation":[{"name":"College of Acupuncture and Tuina Chengdu University of Traditional Chinese Medicine Chengdu China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tingting","family":"Yu","sequence":"additional","affiliation":[{"name":"College of Acupuncture and Tuina Chengdu University of Traditional Chinese Medicine Chengdu China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wangjiao","family":"Li","sequence":"additional","affiliation":[{"name":"College of Acupuncture and Tuina Chengdu University of Traditional Chinese Medicine Chengdu China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiansheng","family":"Li","sequence":"additional","affiliation":[{"name":"Chengdu Tianfu Middle School Chengdu China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5285-8680","authenticated-orcid":false,"given":"Jing","family":"Xu","sequence":"additional","affiliation":[{"name":"College of Acupuncture and Tuina Chengdu University of Traditional Chinese Medicine Chengdu China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,4,5]]},"reference":[{"issue":"6","key":"e_1_2_14_2_1","first-page":"321","article-title":"Review of the Current Status of Facial Rejuvenation Treatments in China","volume":"31","author":"Hao L.","year":"2020","journal-title":"Zhongguo Mei Rong Zheng Xing Wai Ke Za Zhi (Chinese Journal of Aesthetic and Plastic Surgery)"},{"key":"e_1_2_14_3_1","doi-asserted-by":"publisher","DOI":"10.19593\/j.issn.2095\u20100721.2022.01.021"},{"key":"e_1_2_14_4_1","doi-asserted-by":"publisher","DOI":"10.3390\/cells11162541"},{"key":"e_1_2_14_5_1","doi-asserted-by":"publisher","DOI":"10.3389\/fphys.2023.1195272"},{"key":"e_1_2_14_6_1","doi-asserted-by":"publisher","DOI":"10.1159\/000534756"},{"key":"e_1_2_14_7_1","doi-asserted-by":"publisher","DOI":"10.1055\/s\u20100036\u20101584818"},{"key":"e_1_2_14_8_1","doi-asserted-by":"publisher","DOI":"10.1111\/jocd.16657"},{"key":"e_1_2_14_9_1","doi-asserted-by":"publisher","DOI":"10.3760\/cma.j.issn.1671\u20100290.2020.01.001"},{"key":"e_1_2_14_10_1","doi-asserted-by":"publisher","DOI":"10.1155\/2013\/424313"},{"key":"e_1_2_14_11_1","doi-asserted-by":"publisher","DOI":"10.1111\/jocd.70144"},{"key":"e_1_2_14_12_1","doi-asserted-by":"publisher","DOI":"10.3892\/etm.2021.9615"},{"key":"e_1_2_14_13_1","doi-asserted-by":"publisher","DOI":"10.1002\/jcsm.12332"},{"issue":"2","key":"e_1_2_14_14_1","first-page":"185","article-title":"The Cosmetology View of \u201cHuangdi Neijing \u201d and Its Clinical Guidance for Acupuncture Cosmetology","volume":"45","author":"Sun J.","year":"2021","journal-title":"Zhejiang Zhong Yi Yao Da Xue Xue Bao = Journal of Zhejiang Chinese Medical University"},{"key":"e_1_2_14_15_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00405\u2010009\u20101107\u20104"},{"key":"e_1_2_14_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.wjam.2018.05.003"},{"key":"e_1_2_14_17_1","doi-asserted-by":"publisher","DOI":"10.1111\/jocd.12007"},{"key":"e_1_2_14_18_1","doi-asserted-by":"publisher","DOI":"10.1093\/asj\/sjaf009"},{"key":"e_1_2_14_19_1","doi-asserted-by":"publisher","DOI":"10.1093\/bbb\/zbae017"},{"key":"e_1_2_14_20_1","doi-asserted-by":"publisher","DOI":"10.13703\/j.0255\u20102930.20210701\u2010k0002"},{"key":"e_1_2_14_21_1","doi-asserted-by":"publisher","DOI":"10.1093\/asj\/sjad053"},{"key":"e_1_2_14_22_1","doi-asserted-by":"publisher","DOI":"10.1111\/jocd.16749"},{"key":"e_1_2_14_23_1","doi-asserted-by":"publisher","DOI":"10.1093\/asj\/sjae252"},{"key":"e_1_2_14_24_1","doi-asserted-by":"publisher","DOI":"10.3390\/cosmetics6030050"},{"key":"e_1_2_14_25_1","doi-asserted-by":"publisher","DOI":"10.3390\/biom5020545"},{"key":"e_1_2_14_26_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms20092126"},{"key":"e_1_2_14_27_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11010\u2010020\u201003912\u20106"},{"key":"e_1_2_14_28_1","doi-asserted-by":"publisher","DOI":"10.3390\/antiox11061121"},{"key":"e_1_2_14_29_1","doi-asserted-by":"publisher","DOI":"10.1177\/0963689717725755"},{"key":"e_1_2_14_30_1","doi-asserted-by":"publisher","DOI":"10.3390\/molecules26030662"},{"key":"e_1_2_14_31_1","doi-asserted-by":"publisher","DOI":"10.3390\/polym13213790"},{"key":"e_1_2_14_32_1","doi-asserted-by":"publisher","DOI":"10.3389\/fbioe.2025.1662900"},{"key":"e_1_2_14_33_1","doi-asserted-by":"publisher","DOI":"10.1089\/wound.2013.0427"},{"key":"e_1_2_14_34_1","doi-asserted-by":"publisher","DOI":"10.1242\/jcs.00868"},{"key":"e_1_2_14_35_1","doi-asserted-by":"publisher","DOI":"10.1159\/000506517"},{"key":"e_1_2_14_36_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.041359198"},{"key":"e_1_2_14_37_1","doi-asserted-by":"publisher","DOI":"10.13703\/j.0255\u20102930.20240824\u20100001"},{"key":"e_1_2_14_38_1","doi-asserted-by":"publisher","DOI":"10.1089\/wound.2011.0356"}],"container-title":["Journal of Cosmetic Dermatology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/jocd.70839","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/jocd.70839","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/jocd.70839","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,6,24]],"date-time":"2026-06-24T09:23:53Z","timestamp":1782293033000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/jocd.70839"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,4]]},"references-count":37,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2026,4]]}},"alternative-id":["10.1111\/jocd.70839"],"URL":"https:\/\/doi.org\/10.1111\/jocd.70839","archive":["Portico"],"relation":{},"ISSN":["1473-2130","1473-2165"],"issn-type":[{"value":"1473-2130","type":"print"},{"value":"1473-2165","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,4]]},"assertion":[{"value":"2025-12-10","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-03-23","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-04-05","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e70839"}}