{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,24]],"date-time":"2026-06-24T09:48:21Z","timestamp":1782294501415,"version":"3.54.5"},"reference-count":35,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2026,4,24]],"date-time":"2026-04-24T00:00:00Z","timestamp":1776988800000},"content-version":"vor","delay-in-days":23,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,4,1]],"date-time":"2026-04-01T00:00:00Z","timestamp":1775001600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Cosmetic Dermatology"],"published-print":{"date-parts":[[2026,4]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Hyaluronic acid (HA) products used for nasolabial fold (NLF) correction are typically crosslinked with 1,4\u2010Butanediol diglycidyl ether (BDDE) and contain high HA concentrations and short HA chains. These characteristics may contribute to increased stiffness, enhanced immune reactivity, and less natural aesthetic outcomes. A novel HA material utilizing click\u2010chemistry for crosslinking to preserve long\u2010chain structure and afford low HA concentration and minimal modification was developed as a potential alternative.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Aim<\/jats:title>\n                    <jats:p>The aim of this study was to evaluate the 12\u2010month safety and clinical performance of a non\u2010BDDE, click\u2010chemistry crosslinked, long\u2010chain HA compound (HLR\u20102, Hallura) for NLF correction.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Two prospective, open\u2010label studies were conducted, one in Europe and the other in Israel. All subjects received HLR\u20102 injections and were followed for 12\u2009months. Efficacy was assessed by the Wrinkle Severity Rating Scale, Global Aesthetic Improvement Scale, and patient satisfaction measures. Safety was monitored through reporting of adverse events (AE) and documentation of injection site reactions (ISR).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Sixty\u2010two subjects (29 Israeli and 33 European) were included. Responder rates at 6\u2009months were 90.7% and 86.4%, respectively, with improvements sustained throughout 12\u2009months. Satisfaction levels remained high (\u2265\u200994% at all time points). ISRs were mild and transient, with no serious or delayed\u2010onset AEs, and favorable induction of collagen and elastin and enhanced tissue integration were documented.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>HLR\u20102 demonstrated high efficacy, high patient satisfaction, and a favorable safety profile over 12\u2009months. The product's distinctive composition and clinical performance support its use for aesthetic indications, with potential for broader therapeutic applications.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/jocd.70840","type":"journal-article","created":{"date-parts":[[2026,4,24]],"date-time":"2026-04-24T14:23:04Z","timestamp":1777040584000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Twelve\u2010Month Outcome of Nasolabial Fold Correction by a Novel Non\u20101,4\u2010Butanediol Diglycidyl Ether, Click\u2010Crosslinked, Long\u2010Chain Hyaluronic Acid Product"],"prefix":"10.1111","volume":"25","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1503-3959","authenticated-orcid":false,"given":"Ari","family":"Safir","sequence":"first","affiliation":[{"name":"Division of Dermatology Tel Aviv Sourasky Medical Center  Tel Aviv Israel"},{"name":"Faculty of Medical &amp; Health Sciences Tel Aviv University  Tel Aviv Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sonja","family":"Sattler","sequence":"additional","affiliation":[{"name":"Rosenpark Klinik  Darmstadt Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rodrigo","family":"Da Mota","sequence":"additional","affiliation":[{"name":"Private Practice Dr. Hilton &amp; Partner for Dermatology  D\u00fcsseldorf Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elzbieta","family":"Kowalska\u2010Ol\u0119dzka","sequence":"additional","affiliation":[{"name":"Maria Sk\u0142odowska\u2010Curie Medical Academy in Warsaw  Warsaw Poland"},{"name":"Evimed  Warsaw Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniel J.","family":"Kedar","sequence":"additional","affiliation":[{"name":"Faculty of Medical &amp; Health Sciences Tel Aviv University  Tel Aviv Israel"},{"name":"Department of Plastic and Reconstructive Surgery Sourasky Medical Center  Tel Aviv Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yoav","family":"Gronovich","sequence":"additional","affiliation":[{"name":"Department of Plastic and Reconstructive Surgery Shaare Zedek Medical Center  Jerusalem Israel"},{"name":"Faculty of Medicine Hebrew University of Jerusalem  Jerusalem Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Adi Maisel","family":"Lotan","sequence":"additional","affiliation":[{"name":"Department of Plastic and Reconstructive Surgery Shaare Zedek Medical Center  Jerusalem Israel"},{"name":"Faculty of Medicine Hebrew University of Jerusalem  Jerusalem Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Svetlana","family":"Shneider","sequence":"additional","affiliation":[{"name":"Hallura R&amp;D  Yokneam Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stephane","family":"Meunier","sequence":"additional","affiliation":[{"name":"Hallura R&amp;D  Yokneam Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ofir","family":"Artzi","sequence":"additional","affiliation":[{"name":"Division of Dermatology Tel Aviv Sourasky Medical Center  Tel Aviv Israel"},{"name":"Faculty of Medical &amp; Health Sciences Tel Aviv University  Tel Aviv Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,4,24]]},"reference":[{"key":"e_1_2_11_2_1","doi-asserted-by":"publisher","DOI":"10.1080\/17434440.2021.2014320"},{"key":"e_1_2_11_3_1","doi-asserted-by":"publisher","DOI":"10.1039\/D2BM01154A"},{"key":"e_1_2_11_4_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00266-024-04262-0"},{"key":"e_1_2_11_5_1","doi-asserted-by":"publisher","DOI":"10.1055\/a-2184-6554"},{"key":"e_1_2_11_6_1","doi-asserted-by":"publisher","DOI":"10.1002\/adfm.201706046"},{"key":"e_1_2_11_7_1","doi-asserted-by":"publisher","DOI":"10.1021\/ar200193f"},{"key":"e_1_2_11_8_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00266-021-02439-5"},{"key":"e_1_2_11_9_1","first-page":"277","article-title":"Clinical Implications of Delayed\u2010Onset Inflammatory Reactions to Hyaluronic Acid Fillers: A Review","volume":"11","author":"Snozzi P.","year":"2018","journal-title":"Clinical, Cosmetic and Investigational Dermatology"},{"key":"e_1_2_11_10_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1524-4725.2008.01046.x"},{"key":"e_1_2_11_11_1","doi-asserted-by":"publisher","DOI":"10.2165\/00128071-200405010-00007"},{"key":"e_1_2_11_12_1","doi-asserted-by":"publisher","DOI":"10.1055\/s-0030-1262313"},{"key":"e_1_2_11_13_1","doi-asserted-by":"publisher","DOI":"10.1093\/asj\/sjad374"},{"key":"e_1_2_11_14_1","unstructured":"Administration USFaD \u201cSummary of Safety and Effectiveness Data (SSED) for Juv\u00e9derm Vollure XC \u201d(Center for Devices and Radiological Health (CDRH) U.S. Food and Drug Administration 2017). 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