{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,13]],"date-time":"2026-06-13T03:00:29Z","timestamp":1781319629899,"version":"3.54.1"},"reference-count":22,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2026,5,17]],"date-time":"2026-05-17T00:00:00Z","timestamp":1778976000000},"content-version":"vor","delay-in-days":16,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T00:00:00Z","timestamp":1777593600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Cosmetic Dermatology"],"published-print":{"date-parts":[[2026,5]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Diffuse hair loss and shedding is often managed with food supplements, yet evidence for ingredient combinations is limited. Our exploratory study evaluated a nutritional supplement (Priorin capsules, Bayer) containing millet extract, pantothenic acid (vitamin B5), L\u2010cystine, and biotin (vitamin B7) in healthy subjects with light diffuse hair loss.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>In this open\u2010label, intra\u2010individual, multicenter study, subjects with non\u2010illness\u2010related, light diffuse hair loss used the product (two capsules\/day) for 12\u2009weeks. Endpoints included objective measurements of hair density, hair growth coefficient, and hair loss (phototrichogram), subjective evaluations of hair appearance, beauty and volume (hairdresser\u2010rated), consumer perception and acceptance, and tolerability.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      In 112 subjects (mean age 32\u2009\u00b1\u20091\u2009years; 93.8% female), hair density (\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u2009109) and the proportion of hairs in the anagen phase increased significantly, while the telogen proportion decreased (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.001, week 12 vs. baseline). Hair loss had declined by 59% at week 12 (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.001). Significant improvements in the hairdresser\u2010rated hair quality and appearance parameters (shine, softness\/elasticity, strength, smoothness, dryness, vitality, volume) were observed (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.001). From week 2, subjects reported progressive improvement in appearance, growth, and slowing of hair loss. At week 12, 90% of subjects perceived improved hair appearance and growth, 85% reported slowing down of hair loss, and 82% were satisfied with the overall hair improvements with treatment. The supplement was generally well tolerated.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>The combination of millet extract, pantothenic acid, L\u2010cystine, and biotin was associated with reduced hair loss, improvements in hair growth and appearance, and high subject satisfaction, and was well tolerated over 12\u2009weeks.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/jocd.70852","type":"journal-article","created":{"date-parts":[[2026,5,18]],"date-time":"2026-05-18T05:35:48Z","timestamp":1779082548000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Effectiveness, Tolerability, and Acceptance of a Food Supplement in the Management of Non\u2010Illness\u2010Related Hair Loss and Thinning"],"prefix":"10.1111","volume":"25","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5816-1822","authenticated-orcid":false,"given":"Ehrhardt","family":"Proksch","sequence":"first","affiliation":[{"name":"Clinic for Dermatology, Allergology and Venereology, University Hospital Schleswig\u2010Holstein, Campus Kiel  Kiel Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0003-0655-0425","authenticated-orcid":false,"given":"Sandra","family":"Bartylla","sequence":"additional","affiliation":[{"name":"Steigerwald Arzneimittelwerk GmbH  Darmstadt Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,5,17]]},"reference":[{"key":"e_1_2_12_2_1","doi-asserted-by":"publisher","DOI":"10.1101\/cshperspect.a013615"},{"key":"e_1_2_12_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.0022-202X.2004.23237.x"},{"key":"e_1_2_12_4_1","doi-asserted-by":"publisher","DOI":"10.3949\/ccjm.76a.08080"},{"key":"e_1_2_12_5_1","doi-asserted-by":"publisher","DOI":"10.4103\/idoj.IDOJ_129_18"},{"key":"e_1_2_12_6_1","volume-title":"StatPearls [Internet]","author":"Hughes E.","year":"2025"},{"key":"e_1_2_12_7_1","doi-asserted-by":"publisher","DOI":"10.1007\/978-3-030-29101-3_40"},{"key":"e_1_2_12_8_1","doi-asserted-by":"publisher","DOI":"10.1093\/bjd\/ljaf085.164"},{"issue":"5","key":"e_1_2_12_9_1","article-title":"Understanding the Association Between Mental Health and Hair Loss","volume":"17","author":"Malta M.","year":"2025","journal-title":"Cureus"},{"key":"e_1_2_12_10_1","doi-asserted-by":"publisher","DOI":"10.1111\/jocd.12998"},{"key":"e_1_2_12_11_1","doi-asserted-by":"publisher","DOI":"10.3389\/fphar.2023.1172084"},{"key":"e_1_2_12_12_1","volume-title":"StatPearls [Internet]","author":"Sanvictores T.","year":"2025"},{"key":"e_1_2_12_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/B978-044452260-3\/50045-0"},{"key":"e_1_2_12_14_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0625.2009.00884.x"},{"key":"e_1_2_12_15_1","doi-asserted-by":"publisher","DOI":"10.1007\/978-3-031-55474-2_10"},{"key":"e_1_2_12_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0378-4347(00)83563-X"},{"key":"e_1_2_12_17_1","doi-asserted-by":"publisher","DOI":"10.2147\/CCID.S254720"},{"key":"e_1_2_12_18_1","doi-asserted-by":"publisher","DOI":"10.1080\/15569520500536584"},{"key":"e_1_2_12_19_1","unstructured":"T. W.Fischer \u201cPO74: Modulating Effects of Calcium\u2010Pantothenate L\u2010Cystin and Millet Seed Extract on Functional and Regulatory Growth Parameters in Human Hair Follicles in Vitro \u201dPaper presented at: 9th World Congress for Hair Research November 18\u201321. A Comprehensive International Hair Research Meeting for the Advancement of Knowledge in Hair Growth Hair and Scalp Disease and Clinical Care 2015; Miami Florida USA."},{"key":"e_1_2_12_20_1","doi-asserted-by":"publisher","DOI":"10.3390\/jcm12030893"},{"key":"e_1_2_12_21_1","first-page":"419","article-title":"Das Phototrichogramm als Verfahren zur Beurteilung haarwachstumsf\u00f6rdernder Pr\u00e4parate am Beispiel einer Kombination von Hirsefruchtextrakt, L\u2010Cystin und Calciumpantothenat: Ergebnisse Einer In\u00a0Vivo Untersuchung bei Frauen mit androgenetischem Haarausfall","volume":"75","author":"Gehring W.","year":"2000","journal-title":"Zeitschrift f\u00fcr Hautkrankheiten"},{"issue":"3","key":"e_1_2_12_22_1","first-page":"280","article-title":"Therapy of Androgenetic Alopecia \u2013 Results of a Non\u2010Interventional Observational Study on the Efficacy of Priorin","volume":"55","author":"B\u00fchling K. J.","year":"2014","journal-title":"Frauenarzt"},{"issue":"47","key":"e_1_2_12_23_1","first-page":"1457","article-title":"The Efficacy of Drug Therapy in Structural Lesions of the Hair and in Diffuse Effluvium\u2014Comparative Double Blind Study","volume":"79","author":"Petri H.","year":"1990","journal-title":"Schweizerische Rundschau f\u00fcr Medizin Praxis"}],"container-title":["Journal of Cosmetic Dermatology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/jocd.70852","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/jocd.70852","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/jocd.70852","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,6,13]],"date-time":"2026-06-13T02:46:34Z","timestamp":1781318794000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/jocd.70852"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,5]]},"references-count":22,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2026,5]]}},"alternative-id":["10.1111\/jocd.70852"],"URL":"https:\/\/doi.org\/10.1111\/jocd.70852","archive":["Portico"],"relation":{},"ISSN":["1473-2130","1473-2165"],"issn-type":[{"value":"1473-2130","type":"print"},{"value":"1473-2165","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,5]]},"assertion":[{"value":"2025-11-04","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-03-23","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-05-17","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e70852"}}