{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,13]],"date-time":"2026-06-13T03:00:35Z","timestamp":1781319635454,"version":"3.54.1"},"reference-count":19,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2026,5,5]],"date-time":"2026-05-05T00:00:00Z","timestamp":1777939200000},"content-version":"vor","delay-in-days":4,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T00:00:00Z","timestamp":1777593600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Cosmetic Dermatology"],"published-print":{"date-parts":[[2026,5]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>In recent years, skin photoaging has received increasing attention, and laser therapy has become the most commonly used treatment due to its safety and efficacy; emerging evidence suggests that adjunctive \u201cintegrated skincare\u201d may enhance treatment benefits by reducing post\u2010procedural reactions and supporting skin barrier repair.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>The split\u2010face, double\u2010blind, randomized, placebo\u2010controlled, monocentric clinical trial was conducted to validate the potential efficacy of anti\u2010photoaging and skin repair of a multifunctional serum formulation following a one\u2010session therapy of 1064\u2010nm picosecond Nd:YAG laser.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>A total of twenty\u2010four participants requesting picosecond laser therapy to address age\u2010associated facial alterations were recruited for the study. Following a two\u2010week washout period, participants underwent a single laser session on Day 1 (T1d) and applied either the multi\u2010beneficial serum or the placebo to the designated facial side twice daily for eight weeks. Their facial skin manifestations were assessed by two dermatologists at baseline, T0, T15d, T29d, and T57d, and the Symptom Score Reduction Index (SSRI) was analyzed later. Non\u2010invasive measurements and self\u2010assessments were also administered at each visit.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Twenty\u2010four women aged 30\u201348\u2009years completed the trial. The scores for all other manifestations of skin photoaging, with the exception of coarse wrinkles, decreased on both the test and control sides throughout follow\u2010up. Based on SSRI values for individual photoaging signs, clinical efficacy rates for the test sides were superior to their counterparts. Regarding skin barrier function, decreasing transepidermal water loss and increasing stratum corneum hydration were observed on the test side during the period of recovery, with significant intergroup differences on T29d and T57d. Skin tone indicators (erythema index, melanin index, and tone evenness) rose shortly after the laser treatment and then declined on both sides; the magnitudes of reductions were greater on the test sides than on the control ones. Even though the improvement of skin surface evenness was found due to the therapy, the test sides exhibited more favorable changes than the controls, for instance, a reduction in the area proportion of crow's feet. No adverse events related to the test product were found during the study.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>The test serum enhanced the efficacy of 1064\u2010nm picosecond laser treatment for facial photoaging and supported skin barrier recovery.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/jocd.70886","type":"journal-article","created":{"date-parts":[[2026,5,6]],"date-time":"2026-05-06T05:04:58Z","timestamp":1778043898000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Efficacy of 1064\u2010Nm Picosecond Nd:\n                    <scp>YAG<\/scp>\n                    Laser in Treating Facial Photoaging and Improving Skin Barrier Enhanced by a Multi\u2010Beneficial Composition Formulation: A Blinded Randomized Clinical Trial Study"],"prefix":"10.1111","volume":"25","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5148-8961","authenticated-orcid":false,"given":"Yixuan","family":"He","sequence":"first","affiliation":[{"name":"Sino United Health  Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0008-4576-123X","authenticated-orcid":false,"given":"Manru","family":"Ning","sequence":"additional","affiliation":[{"name":"Yunnan Characteristic Plant Extraction Laboratory Co., Ltd.  Kunming Yunnan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0002-1896-2075","authenticated-orcid":false,"given":"Feifei","family":"Wang","sequence":"additional","affiliation":[{"name":"Yunnan Botanee Bio\u2010Technology Group Co., Ltd.  Kunming Yunnan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1430-8124","authenticated-orcid":false,"given":"Yihuai","family":"Liang","sequence":"additional","affiliation":[{"name":"Yunnan Characteristic Plant Extraction Laboratory Co., Ltd.  Kunming Yunnan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0006-4430-8148","authenticated-orcid":false,"given":"Shuxian","family":"Yan","sequence":"additional","affiliation":[{"name":"Sino United Health  Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,5,5]]},"reference":[{"key":"e_1_2_12_2_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10103-020-03008-z"},{"key":"e_1_2_12_3_1","doi-asserted-by":"publisher","DOI":"10.1002\/lsm.23404"},{"key":"e_1_2_12_4_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10103-020-02950-2"},{"key":"e_1_2_12_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/phpp.12673"},{"key":"e_1_2_12_6_1","doi-asserted-by":"publisher","DOI":"10.1002\/lsm.23635"},{"key":"e_1_2_12_7_1","doi-asserted-by":"publisher","DOI":"10.1111\/jdv.19975"},{"key":"e_1_2_12_8_1","doi-asserted-by":"publisher","DOI":"10.1111\/jdv.19606"},{"key":"e_1_2_12_9_1","doi-asserted-by":"publisher","DOI":"10.3390\/molecules26154429"},{"key":"e_1_2_12_10_1","doi-asserted-by":"publisher","DOI":"10.1111\/jdv.19647"},{"key":"e_1_2_12_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jdermsci.2016.08.004"},{"key":"e_1_2_12_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.fitote.2012.12.020"},{"key":"e_1_2_12_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopha.2019.109600"},{"key":"e_1_2_12_14_1","doi-asserted-by":"publisher","DOI":"10.18520\/cs\/v119\/i5\/790-798"},{"key":"e_1_2_12_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bjp.2016.01.004"},{"issue":"1","key":"e_1_2_12_16_1","first-page":"17","article-title":"L\u2010Ergothioneine Scavenges Superoxide and Singlet Oxygen and Suppresses TNF\u2010Alpha and MMP\u20101 Expression in UV\u2010Irradiated Human Dermal Fibroblasts","volume":"56","author":"Obayashi K.","year":"2005","journal-title":"Journal of Cosmetic Science"},{"key":"e_1_2_12_17_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1524-4725.2010.01726.x"},{"key":"e_1_2_12_18_1","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1155\/2018\/2141389","article-title":"Screening and Characterizing Tyrosinase Inhibitors From Salvia Miltiorrhiza and Carthamus tinctorius by Spectrum\u2010Effect Relationship Analysis and Molecular Docking","volume":"2018","author":"Wang Y. 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