{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,13]],"date-time":"2026-06-13T03:00:38Z","timestamp":1781319638705,"version":"3.54.1"},"reference-count":22,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2026,5,5]],"date-time":"2026-05-05T00:00:00Z","timestamp":1777939200000},"content-version":"vor","delay-in-days":4,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T00:00:00Z","timestamp":1777593600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Cosmetic Dermatology"],"published-print":{"date-parts":[[2026,5]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Skin glycation, oxidation, carbonylation, and excessive inflammation are well\u2010recognized factors contributing to skin aging and pigmentation. Previous in\u00a0vitro studies have confirmed vitamin C's antioxidant, anti\u2010glycation, and anti\u2010inflammatory properties, but its in\u00a0vivo effects remain to be further verified.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Aims<\/jats:title>\n                    <jats:p>To investigate the in\u00a0vivo effects of topical vitamin C serum on skin anti\u2010glycation, anti\u2010carbonylation, antioxidation, and anti\u2010inflammation, and to provide evidence for its anti\u2010aging and skin\u2010brightening applications.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Patients\/Methods<\/jats:title>\n                    <jats:p>A randomized, double\u2010blind, controlled trial was conducted, enrolling 66 healthy Chinese females, with 31 in the blank group and 35 in the topical group. Participants applied 10% vitamin C serum for 12\u2009weeks. Skin glycation, carbonylated protein content, interleukin\u20101\u03b1 (IL\u20101\u03b1) levels, free radical scavenging capacity, and skin color parameters were evaluated before and after treatment.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      After 12\u2009weeks, the topical group showed significant improvements: AGEs reduced by 17.65%, carbonylation fluorescence intensity decreased by 49.22%, IL\u20101\u03b1 content dropped by 58.73%, and ABTS free radical scavenging rate increased by 12.14%. Skin yellowness (b* value) and redness (a* value) decreased by 6.13% and 16.46%, respectively (all\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.001).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Topical 10% vitamin C serum can effectively mitigate skin glycation, carbonylation, and inflammation, enhance skin antioxidant capacity, and improve skin color, supporting its clinical value in anti\u2010aging and skin\u2010brightening.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/jocd.70888","type":"journal-article","created":{"date-parts":[[2026,5,6]],"date-time":"2026-05-06T05:33:06Z","timestamp":1778045586000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Study on the Multiple Efficacies of Vitamin C Serum in Anti\u2010Glycation, Anti\u2010Carbonylation, Antioxidation, and Anti\u2010Inflammation of Human Skin Based on In\u00a0Vivo Tests"],"prefix":"10.1111","volume":"25","author":[{"ORCID":"https:\/\/orcid.org\/0009-0007-4530-3194","authenticated-orcid":false,"given":"Yusha","family":"Zi","sequence":"first","affiliation":[{"name":"Amway (Shanghai) Technology Development Co., Ltd.  Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jianwei","family":"Liu","sequence":"additional","affiliation":[{"name":"Amway (Shanghai) Technology Development Co., Ltd.  Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qi","family":"Liu","sequence":"additional","affiliation":[{"name":"Beijing EWISH Testing Technology Co., Ltd.  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8092-4865","authenticated-orcid":false,"given":"Yao","family":"Pan","sequence":"additional","affiliation":[{"name":"Department of Cosmetics, School of Light Industry Science and Engineering Beijing Technology and Business University  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0008-7131-9293","authenticated-orcid":false,"given":"Xiuyu","family":"Jiang","sequence":"additional","affiliation":[{"name":"Amway (Shanghai) Technology Development Co., Ltd.  Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,5,5]]},"reference":[{"key":"e_1_2_10_2_1","first-page":"190","article-title":"Glycation and Metabolic Syndrome in the Skin Premature Aging","volume":"8","author":"Janovska J.","year":"2021","journal-title":"Glycative Stress Research"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.3390\/antiox11112281"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.4161\/derm.22028"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/exd.13821"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jdermsci.2011.06.015"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1467-2494.2004.00241.x"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.1034\/j.1600-0625.2002.110303.x"},{"key":"e_1_2_10_9_1","doi-asserted-by":"publisher","DOI":"10.1111\/exd.12899"},{"key":"e_1_2_10_10_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0169788"},{"key":"e_1_2_10_11_1","doi-asserted-by":"publisher","DOI":"10.5650\/jos.ess16074"},{"key":"e_1_2_10_12_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11357-024-01364-0"},{"key":"e_1_2_10_13_1","doi-asserted-by":"publisher","DOI":"10.15407\/ubj94.04.061"},{"key":"e_1_2_10_14_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.jid.5700572"},{"key":"e_1_2_10_15_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00403-017-1729-0"},{"key":"e_1_2_10_16_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0846.2007.00195.x"},{"key":"e_1_2_10_17_1","doi-asserted-by":"publisher","DOI":"10.1111\/ics.12728"},{"key":"e_1_2_10_18_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms14059126"},{"key":"e_1_2_10_19_1","doi-asserted-by":"publisher","DOI":"10.1002\/VIW.20210012"},{"key":"e_1_2_10_20_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms25115596"},{"key":"e_1_2_10_21_1","doi-asserted-by":"publisher","DOI":"10.1111\/exd.15163"},{"key":"e_1_2_10_22_1","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2021.808012"},{"key":"e_1_2_10_23_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.alit.2021.05.005"}],"container-title":["Journal of Cosmetic Dermatology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/jocd.70888","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/jocd.70888","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/jocd.70888","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,6,13]],"date-time":"2026-06-13T02:47:56Z","timestamp":1781318876000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/jocd.70888"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,5]]},"references-count":22,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2026,5]]}},"alternative-id":["10.1111\/jocd.70888"],"URL":"https:\/\/doi.org\/10.1111\/jocd.70888","archive":["Portico"],"relation":{},"ISSN":["1473-2130","1473-2165"],"issn-type":[{"value":"1473-2130","type":"print"},{"value":"1473-2165","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,5]]},"assertion":[{"value":"2026-01-25","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-04-15","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-05-05","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e70888"}}