{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,29]],"date-time":"2026-08-29T10:24:46Z","timestamp":1787999086776,"version":"build-2784847793"},"reference-count":22,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2026,5,5]],"date-time":"2026-05-05T00:00:00Z","timestamp":1777939200000},"content-version":"vor","delay-in-days":4,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T00:00:00Z","timestamp":1777593600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Cosmetic Dermatology"],"published-print":{"date-parts":[[2026,5]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>The 589\/1319\u2009nm solid\u2010state dual\u2010wavelength (SSDW) laser, which targets cutaneous vasculature, may be an effective treatment for acne erythema (AE).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objectives<\/jats:title>\n                    <jats:p>\n                      To compare the efficacy and safety of the 589\/1319\u2009nm SSDW laser with topical soothing\n                      <jats:styled-content style=\"fixed-case\">\n                        <jats:italic>Aloe vera<\/jats:italic>\n                      <\/jats:styled-content>\n                      (AV) gel for the treatment of AE.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Patients and Methods<\/jats:title>\n                    <jats:p>Thirty patients with bilateral AE were enrolled. One facial side received 6 sessions of 589\/1319\u2009nm SSDW laser treatment, while the contralateral side was treated with twice\u2010daily AV gel for 18\u2009weeks. Patients were followed for 8\u2009weeks after the final laser session. AE severity, acne severity, and adverse events were assessed.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Twenty\u2010nine patients completed the study. Both treatment modalities significantly reduced AE. The laser\u2010treated side demonstrated a faster clinical response, with a significant reduction compared to baseline at 2\u2009weeks, whereas AV gel required 4\u2009weeks to achieve a comparable effect (within\u2010group\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.05; no between\u2010group difference). At the 8\u2010week follow\u2010up, the response rate was 72% for the laser\u2010treated sides and 69% for the AV\u2010treated sides. AE improvement correlated with reductions in acne severity in the laser\u2010treated sides (\n                      <jats:italic>r<\/jats:italic>\n                      <jats:sub>s<\/jats:sub>\n                      \u2009=\u20090.47,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.03). Patients reported higher satisfaction with laser treatment up to 4\u2009weeks after the final laser session. Average pain score for the laser treatment was 1.52 out of 10. No serious adverse events were observed.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>The 589\/1319\u2009nm SSDW laser may be an effective early adjunctive treatment for acne erythema, offering minimal discomfort with no downtime and may additionally improve acne severity.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/jocd.70894","type":"journal-article","created":{"date-parts":[[2026,5,6]],"date-time":"2026-05-06T05:31:22Z","timestamp":1778045482000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Efficacy and Safety of a Dual\u2010Wavelength 589\/1319\u2009nm Laser for the Treatment of Acne Erythema: A Split\u2010Face Randomized Controlled Trial"],"prefix":"10.1111","volume":"25","author":[{"given":"Suphagan","family":"Boonpethkaew","sequence":"first","affiliation":[{"name":"Division of Dermatology, Department of Medicine Ramathibodi Hospital, Mahidol University  Bangkok Thailand"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pimsiri","family":"Anansiripun","sequence":"additional","affiliation":[{"name":"Division of Dermatology, Department of Medicine Ramathibodi Hospital, Mahidol University  Bangkok Thailand"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Warittha","family":"Maitrisathit","sequence":"additional","affiliation":[{"name":"Division of Dermatology, Department of Medicine Ramathibodi Hospital, Mahidol University  Bangkok Thailand"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yanisa","family":"Ratanapokasatit","sequence":"additional","affiliation":[{"name":"Division of Dermatology, Department of Medicine Ramathibodi Hospital, Mahidol University  Bangkok Thailand"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sonphet","family":"Chirasuthat","sequence":"additional","affiliation":[{"name":"Division of Dermatology, Department of Medicine Ramathibodi Hospital, Mahidol University  Bangkok Thailand"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Panrudee","family":"Wechsuruk","sequence":"additional","affiliation":[{"name":"Division of Dermatology, Department of Medicine Ramathibodi Hospital, Mahidol University  Bangkok Thailand"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Penpun","family":"Wattanakrai","sequence":"additional","affiliation":[{"name":"Division of Dermatology, Department of Medicine Ramathibodi Hospital, Mahidol University  Bangkok 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