{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,15]],"date-time":"2026-10-15T19:27:14Z","timestamp":1792092434996,"version":"4.4.0"},"reference-count":24,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2026,5,10]],"date-time":"2026-05-10T00:00:00Z","timestamp":1778371200000},"content-version":"vor","delay-in-days":9,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T00:00:00Z","timestamp":1777593600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Cosmetic Dermatology"],"published-print":{"date-parts":[[2026,5]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Xerosis cutis is characterized by impaired epidermal barrier function, increased transepidermal water loss (TEWL), reduced hydration, and symptoms such as pruritus.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Aims<\/jats:title>\n                    <jats:p>To evaluate the efficacy, tolerability, and subjective perception of a topical formulation containing panthenol, niacinamide, and dipotassium glycyrrhizate in improving skin hydration and barrier function in subjects with dry, sensitive skin.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>In this randomized, intra\u2010individual, split\u2010leg clinical trial, subjects with xerosis applied the test emollient twice daily for 28\u2009days to one pretibial area. The contralateral leg remained untreated as control. Assessments were performed at baseline (T0), 30\u2009min, 24\u2009h, 48\u2009h, day 7 and day 28. Primary outcomes were corneometric stratum corneum hydration and TEWL. Secondary outcomes included deep skin conductance (\u201cdeep moisturization\u201d), desquamation index, surface microrelief regularity (SEr), scaliness (SEsc), dermatologist\u2010rated clinical signs, and participant self\u2010assessment.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Thirty\u2010five participants (31 women; mean age 47.3\u2009\u00b1\u20092.0\u2009years) were included. Compared with baseline (hydration: 21.3\u2009\u00b1\u20091.0 c.u., 95% CI: 19.3\u201323.3; TEWL: 9.2\u2009\u00b1\u20090.3\u2009g\/h\/m\n                      <jats:sup>2<\/jats:sup>\n                      , 95% CI: 8.6\u20139.8) and untreated control, the treated leg showed greater corneometric hydration at all time points: 66.2% (33.9\u2009\u00b1\u20091.4 c.u., 95% CI: 31.1\u201336.7) at day 7 and 74.1% (35.2\u2009\u00b1\u20091.2 c.u., 95% CI: 32.8\u201337.6) at day 28 (all\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.001). TEWL decreased by 11.3% (8.2\u2009\u00b1\u20090.2\u2009g\/h\/m\n                      <jats:sup>2<\/jats:sup>\n                      , 95% CI: 7.8\u20138.6) and 13.5% (7.9\u2009\u00b1\u20090.2\u2009g\/h\/m\n                      <jats:sup>2<\/jats:sup>\n                      , 95% CI: 7.5\u20138.3), respectively (all\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.05). Deep moisturization increased by 5.7% (39.5\u2009\u00b1\u20090.9 \u03bcS at day 7, 95% CI: 37.7\u201341.3) and 7.3% (41.1\u2009\u00b1\u20090.8 \u03bcS at day 28, 95% CI: 39.5\u201342.7) (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.05). The desquamation index decreased by 13.0% (29.50%\u2009\u00b1\u20091.67% at day 7, 95% CI: 26.1\u201332.9) and 15.8% (26.77%\u2009\u00b1\u20091.25% at day 28, 95% CI: 24.2\u201329.3), SEr increased by 46.9% (3.38\u2009\u00b1\u20090.15\u2009a.u. at day 7, 95% CI: 3.08\u20133.68) and 54.2% (3.47\u2009\u00b1\u20090.15\u2009a.u. at day 28, 95% CI: 3.17\u20133.77), and SEsc decreased by 67.0% (0.81\u2009\u00b1\u20090.12\u2009a.u. at day 7, 95% CI: 0.57\u20131.05) and 76.3% (0.51\u2009\u00b1\u20090.07\u2009a.u. at day 28, 95% CI: 0.37\u20130.65), respectively (all\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.05). Dermatologist assessments at all time points showed significant clinical improvement in dryness and pruritus in all participants (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.001). Complete resolution was observed in all participants according to the 5\u2010point scale, though this may reflect a floor effect given mild baseline scores.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>The topical formulation appeared to be an effective and well\u2010tolerated emollient; however, the absence of a vehicle control precludes attribution of effects specifically to the active ingredients. Patient\u2010reported outcomes should be interpreted with caution due to the unblinded design.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/jocd.70898","type":"journal-article","created":{"date-parts":[[2026,5,11]],"date-time":"2026-05-11T05:00:42Z","timestamp":1778475642000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Efficacy of a Topical Formulation on Skin Hydration and Barrier Function in Individuals With Xerosis: A 28\u2010Day Randomized, Split\u2010Leg, Untreated\u2010Controlled Trial"],"prefix":"10.1111","volume":"25","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4704-6132","authenticated-orcid":false,"given":"Daniel","family":"Morgado\u2010Carrasco","sequence":"first","affiliation":[{"name":"Dermatology Department Hospital Cl\u00ednic de Barcelona, Universitat de Barcelona  Barcelona Spain"},{"name":"Dermatology Department Hospital de Figueres, Fundaci\u00f3 Salut Empord\u00e0  Figueres Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0006-1751-8959","authenticated-orcid":false,"given":"Pablo","family":"Balado\u2010Sim\u00f3","sequence":"additional","affiliation":[{"name":"Dermatology Department Hospital Cl\u00ednic de Barcelona, Universitat de Barcelona  Barcelona Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fernando","family":"Vivancos Cuadras","sequence":"additional","affiliation":[{"name":"Lacer S.A.  Barcelona Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marta","family":"Furmanczyk","sequence":"additional","affiliation":[{"name":"Lacer S.A.  Barcelona Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jes\u00fas","family":"Delgado Ojeda","sequence":"additional","affiliation":[{"name":"Lacer S.A.  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