{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,13]],"date-time":"2026-06-13T03:00:42Z","timestamp":1781319642541,"version":"3.54.1"},"reference-count":23,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2026,5,12]],"date-time":"2026-05-12T00:00:00Z","timestamp":1778544000000},"content-version":"vor","delay-in-days":11,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T00:00:00Z","timestamp":1777593600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81603626"],"award-info":[{"award-number":["81603626"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Cosmetic Dermatology"],"published-print":{"date-parts":[[2026,5]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>To systematically evaluate the efficacy and safety of fractional laser therapy in the treatment of androgenetic alopecia.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>A comprehensive literature search was conducted in PubMed, Web of Science, Embase, the Cochrane Library, and China National Knowledge Infrastructure (CNKI) from inception to November 2025. Eligible studies were selected according to the PICOS framework. The methodological quality of the included studies was assessed using the Cochrane Risk of Bias tool. Meta\u2010analysis was performed using R software.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      A total of 15 studies involving 1097 patients were included. Meta\u2010analysis demonstrated that fractional laser therapy significantly improved hair density compared with control interventions (mean difference [MD]\u2009=\u200913.88, 95% confidence interval [CI]: 6.87\u201320.90,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.001). Subgroup analysis revealed no significant difference in efficacy between ablative and non\u2010ablative fractional lasers (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.7792), nor between different wavelengths (1565\u2009nm, 1550\u2009nm, 1927\u2009nm;\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.7014). Combination therapy with laser and other treatments (e.g., minoxidil) showed a certain advantage over other treatments alone (MD\u2009=\u20099.74,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.001). Adverse events were predominantly mild to moderate, including erythema, pain, and pruritus, all of which resolved spontaneously.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Fractional laser therapy demonstrates marked therapeutic efficacy and a favorable safety profile in the treatment of androgenetic alopecia, making it a viable clinical treatment option. Future high\u2010quality studies are warranted to further validate its long\u2010term effectiveness and optimal treatment parameters.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/jocd.70909","type":"journal-article","created":{"date-parts":[[2026,5,13]],"date-time":"2026-05-13T04:18:56Z","timestamp":1778645936000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Efficacy and Safety of Fractional Laser Therapy for Androgenetic Alopecia: A Systematic Review and Meta\u2010Analysis"],"prefix":"10.1111","volume":"25","author":[{"given":"Cheng","family":"Chen","sequence":"first","affiliation":[{"name":"Affiliated Hospital of Nanjing University of Chinese Medicine Jiangsu Province Hospital of Chinese Medicine  Nanjing China"},{"name":"Nanjing University of Chinese Medicine  Nanjing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shuangshuang","family":"Wang","sequence":"additional","affiliation":[{"name":"Nanjing University of Chinese Medicine  Nanjing China"},{"name":"Community Health Service Center Chengnan Street, Qingjiangpu District  Huai'an China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0007-3166-1118","authenticated-orcid":false,"given":"Dezhao","family":"Bi","sequence":"additional","affiliation":[{"name":"Affiliated Hospital of Nanjing University of Chinese Medicine Jiangsu Province Hospital of Chinese Medicine  Nanjing China"},{"name":"Nanjing University of Chinese Medicine  Nanjing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ang Ching","family":"Wei","sequence":"additional","affiliation":[{"name":"Nanjing University of Chinese Medicine  Nanjing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0001-1954-5639","authenticated-orcid":false,"given":"Shun","family":"Guo","sequence":"additional","affiliation":[{"name":"Affiliated Hospital of Nanjing University of Chinese Medicine Jiangsu Province Hospital of Chinese Medicine  Nanjing China"},{"name":"Nanjing University of Chinese Medicine  Nanjing China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,5,12]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.4103\/npmj.npmj_47_24"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12020\u2010017\u20101280\u2010y"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365\u20102133.2010.09640.x"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1468\u20103083.2001.00229.x"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.1007\/s40265\u2010023\u201001880\u2010x"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.1055\/s\u20100032\u20101329413"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.1111\/jocd.16459"},{"key":"e_1_2_10_9_1","doi-asserted-by":"publisher","DOI":"10.1111\/jocd.15293"},{"key":"e_1_2_10_10_1","doi-asserted-by":"publisher","DOI":"10.19593\/j.issn.2095\u20100721.2025.04.009"},{"issue":"9","key":"e_1_2_10_11_1","first-page":"936","article-title":"Clinical Efficacy of 1565nm Non\u2010Ablative Fractional Laser in Androgenetic Alopecia","volume":"52","author":"Cheng Y.","year":"2024","journal-title":"Tianjin Medical Journal"},{"key":"e_1_2_10_12_1","volume-title":"Clinical Efficacy and Safety Study of 2940 nm Fractional Laser Combined With 5% Minoxidil for the Treatment of Androgenetic Alopecia","author":"Li X.","year":"2025"},{"key":"e_1_2_10_13_1","doi-asserted-by":"publisher","DOI":"10.15909\/j.cnki.cn61\u20101347\/r.006151"},{"issue":"2","key":"e_1_2_10_14_1","first-page":"282","article-title":"Clinical Effect of Non\u2010Stripping Dot Matrix Laser Combined With Finasteride and Minoxidil Tinctureon Male Patients With Androgenic Alopecia","volume":"42","author":"Yang X.","year":"2025","journal-title":"Journal of the Clinical Research"},{"key":"e_1_2_10_15_1","doi-asserted-by":"publisher","DOI":"10.15909\/j.cnki.cn61\u20101347\/r.006344"},{"key":"e_1_2_10_16_1","doi-asserted-by":"publisher","DOI":"10.14188\/j.1671\u20108852.2021.0876"},{"key":"e_1_2_10_17_1","doi-asserted-by":"publisher","DOI":"10.14188\/j.1671\u20108852.2024.0251"},{"key":"e_1_2_10_18_1","doi-asserted-by":"publisher","DOI":"10.3969\/j.issn.1671\u2010945X.2024.04.039"},{"key":"e_1_2_10_19_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10103\u2010019\u201002783\u20108"},{"key":"e_1_2_10_20_1","doi-asserted-by":"publisher","DOI":"10.14188\/j.1671\u20108852.2022.0530"},{"key":"e_1_2_10_21_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10103\u2010024\u201004074\u20103"},{"key":"e_1_2_10_22_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10103\u2010017\u20102232\u20108"},{"key":"e_1_2_10_23_1","doi-asserted-by":"publisher","DOI":"10.1111\/jocd.16173"},{"key":"e_1_2_10_24_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10103\u2010018\u20102437\u20105"}],"container-title":["Journal of Cosmetic Dermatology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/jocd.70909","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/jocd.70909","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/jocd.70909","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,6,13]],"date-time":"2026-06-13T02:50:20Z","timestamp":1781319020000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/jocd.70909"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,5]]},"references-count":23,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2026,5]]}},"alternative-id":["10.1111\/jocd.70909"],"URL":"https:\/\/doi.org\/10.1111\/jocd.70909","archive":["Portico"],"relation":{},"ISSN":["1473-2130","1473-2165"],"issn-type":[{"value":"1473-2130","type":"print"},{"value":"1473-2165","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,5]]},"assertion":[{"value":"2026-01-09","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-04-29","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-05-12","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e70909"}}