{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,13]],"date-time":"2026-06-13T03:00:44Z","timestamp":1781319644195,"version":"3.54.1"},"reference-count":17,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2026,5,20]],"date-time":"2026-05-20T00:00:00Z","timestamp":1779235200000},"content-version":"vor","delay-in-days":19,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T00:00:00Z","timestamp":1777593600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Cosmetic Dermatology"],"published-print":{"date-parts":[[2026,5]]},"abstract":"ABSTRACT<\/jats:title>\n \n Background<\/jats:title>\n Rosacea is characterized by facial erythema that can be resistant to improvement.<\/jats:p>\n <\/jats:sec>\n \n Aims<\/jats:title>\n This research evaluated the efficacy and tolerability of a topical anti\u2010inflammatory moisturizer containing oat and aloe as compared to 0.75% metronidazole cream over 12\u2009weeks.<\/jats:p>\n <\/jats:sec>\n \n Methods<\/jats:title>\n This double\u2010blinded, randomized, controlled trial enrolled 60 adults with mild\u2010to\u2010severe rosacea, randomized to either the study anti\u2010inflammatory moisturizer or 0.75% metronidazole cream daily for 12\u2009weeks. Participants were evaluated at baseline and Weeks 4, 8, and 12. Efficacy was measured by investigator global assessment (IGA) of erythema and inflammatory lesion counts. Tolerability was assessed by the investigator and subjects.<\/jats:p>\n <\/jats:sec>\n \n Results<\/jats:title>\n \n Both study products demonstrated similar IGA scores at Week 4. By Week 8, the study oat and aloe anti\u2010inflammatory moisturizer demonstrated significantly greater reduction in both erythema IGA (50% vs. 22%,\n p<\/jats:italic>\n \u2009=\u20090.001) and lesion counts (74% vs. 6%,\n p<\/jats:italic>\n \u2009=\u20090.015). At the conclusion of the 12\u2010week study, the anti\u2010inflammatory moisturizer produced a reduction in IGA erythema of 54% vs. 23% (\n p<\/jats:italic>\n \u2009<\u20090.001) and a reduction in inflammatory lesion counts of 74% vs. 17% (\n p<\/jats:italic>\n \u2009=\u20090.044). No tolerability issues were noted.\n <\/jats:p>\n <\/jats:sec>\n \n Conclusions<\/jats:title>\n The oat and aloe anti\u2010inflammatory moisturizer was superior and outperformed 0.75% metronidazole cream in both erythema and lesion reduction in rosacea subjects after 8 and 12\u2009weeks of treatment.<\/jats:p>\n <\/jats:sec>","DOI":"10.1111\/jocd.70910","type":"journal-article","created":{"date-parts":[[2026,5,21]],"date-time":"2026-05-21T04:35:12Z","timestamp":1779338112000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Efficacy, Tolerance, and Safety of a Novel Botanical Anti\u2010Inflammatory Moisturizer in Rosacea: Results From a Double\u2010Blinded, Randomized Controlled Trial"],"prefix":"10.1111","volume":"25","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9803-7415","authenticated-orcid":false,"given":"Zoe Diana","family":"Draelos","sequence":"first","affiliation":[{"name":"Dermatology Consulting Services PLCC High Point North Carolina USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,5,20]]},"reference":[{"key":"e_1_2_13_2_1","doi-asserted-by":"publisher","DOI":"10.36849\/JDD.6062"},{"key":"e_1_2_13_3_1","doi-asserted-by":"publisher","DOI":"10.1007\/s13555\u2010015\u20100077\u20102"},{"key":"e_1_2_13_4_1","doi-asserted-by":"publisher","DOI":"10.1007\/s13555\u2010023\u201001087\u20108"},{"key":"e_1_2_13_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jid.2021.02.745"},{"key":"e_1_2_13_6_1","doi-asserted-by":"publisher","DOI":"10.2174\/187221108786241624"},{"key":"e_1_2_13_7_1","doi-asserted-by":"publisher","DOI":"10.3390\/pharmaceutics6010052"},{"key":"e_1_2_13_8_1","doi-asserted-by":"publisher","DOI":"10.1208\/s12249\u2010024\u201002997\u20102"},{"key":"e_1_2_13_9_1","doi-asserted-by":"publisher","DOI":"10.3390\/bioengineering9040158"},{"key":"e_1_2_13_10_1","doi-asserted-by":"publisher","DOI":"10.3390\/ph17020212"},{"key":"e_1_2_13_11_1","doi-asserted-by":"publisher","DOI":"10.35702\/Derm.10015"},{"key":"e_1_2_13_12_1","doi-asserted-by":"publisher","DOI":"10.1002\/ptr.6532"},{"key":"e_1_2_13_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejmech.2022.114511"},{"issue":"2","key":"e_1_2_13_14_1","first-page":"167","article-title":"Colloidal Oatmeal: History, Chemistry and Clinical Properties","volume":"6","author":"Kurtz E. S.","year":"2007","journal-title":"Journal of Drugs in Dermatology"},{"issue":"5","key":"e_1_2_13_15_1","first-page":"271","article-title":"A Status Report on the Medical Management of Rosacea: Focus on Topical Therapies","volume":"70","author":"Del Rosso J. Q.","year":"2002","journal-title":"Cutis"},{"issue":"8","key":"e_1_2_13_16_1","article-title":"A Guide to the Ingredients and Potential Benefits of Over\u2010The\u2010Counter Cleansers and Moisturizers for Rosacea Patients","volume":"4","author":"Levin J.","year":"2011","journal-title":"Journal of Clinical and Aesthetic Dermatology"},{"issue":"2","key":"e_1_2_13_17_1","first-page":"72","article-title":"The Use of Moisturizers as an Integral Component of Topical Therapy for Rosacea: Clinical Results Based on the Assessment of Skin Characteristics Study","volume":"84","author":"Del Rosso J. 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