{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,3]],"date-time":"2026-09-03T12:08:23Z","timestamp":1788437303474,"version":"build-2803163510"},"reference-count":21,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2026,5,12]],"date-time":"2026-05-12T00:00:00Z","timestamp":1778544000000},"content-version":"vor","delay-in-days":11,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T00:00:00Z","timestamp":1777593600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Cosmetic Dermatology"],"published-print":{"date-parts":[[2026,5]]},"abstract":"ABSTRACT<\/jats:title>\n \n Background<\/jats:title>\n \n Fractional CO\n 2<\/jats:sub>\n laser is an effective treatment for skin rejuvenation, although pigmentary complications remain a clinical consideration. Newer generation fractional CO\n 2<\/jats:sub>\n laser systems include pulse modes such as HighPulse (HP), which deliver high energy over a shortened dwell time, reducing the duration of energy delivery per microbeam with the aim of limiting thermal diffusion beyond the ablation zone.\n <\/jats:p>\n <\/jats:sec>\n \n Methods<\/jats:title>\n \n We conducted a single\u2010center retrospective study of 38 patients (Fitzpatrick skin phototypes I\u2013IV) treated with fractional CO\n 2<\/jats:sub>\n laser using HP mode for facial rejuvenation. Pain scores and adverse events were recorded, stratified by skin type and anesthetic use.\n <\/jats:p>\n <\/jats:sec>\n \n Results<\/jats:title>\n Mean pain score was 4.8, with no statistically significant difference between patients who received topical anesthetic (LMX4) and those who did not. Pain scores did not differ significantly across skin phototypes I\u2013IV. Erythema occurred in 50% of patients and edema in 24%, all of which were transient. No cases of blistering, post\u2010inflammatory hyperpigmentation, or scarring were documented in routine clinical records, although the true incidence may be underestimated. Erythema rates did not differ significantly by anesthetic use.<\/jats:p>\n <\/jats:sec>\n \n Conclusions<\/jats:title>\n In this preliminary cohort, the HP fractional laser was associated with transient short\u2010term adverse effects and no documented pigmentary complications among patients with Fitzpatrick skin types I\u2013IV. These findings are descriptive and are not generalizable to Fitzpatrick phototypes V\u2013VI, which were not represented.<\/jats:p>\n <\/jats:sec>","DOI":"10.1111\/jocd.70917","type":"journal-article","created":{"date-parts":[[2026,5,13]],"date-time":"2026-05-13T04:24:57Z","timestamp":1778646297000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Safety and Tolerability of Fractional\n \n CO\n 2<\/sub>\n <\/scp>\n Lasers for Facial Rejuvenation Across Fitzpatrick Skin Phototypes I\u2013\n IV<\/scp>\n : Retrospective Cohort Study"],"prefix":"10.1111","volume":"25","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4694-9089","authenticated-orcid":false,"given":"Ayooluwatomiwa I.","family":"Oloruntoba","sequence":"first","affiliation":[{"name":"Alfred Health Melbourne Victoria Australia"},{"name":"Monash University School of Public Health and Preventative Medicine Melbourne Victoria Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9747-1882","authenticated-orcid":false,"given":"Michelle","family":"Rodrigues","sequence":"additional","affiliation":[{"name":"University of Melbourne Melbourne Victoria Australia"},{"name":"Royal Children's Hospital Melbourne Victoria Australia"},{"name":"Chroma Dermatology, Pigment and Skin of Colour Centre Melbourne Victoria Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,5,12]]},"reference":[{"key":"e_1_2_11_2_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0260095"},{"key":"e_1_2_11_3_1","doi-asserted-by":"publisher","DOI":"10.5978\/islsm.14-RE-01"},{"key":"e_1_2_11_4_1","doi-asserted-by":"publisher","DOI":"10.3390\/medicina59101857"},{"key":"e_1_2_11_5_1","doi-asserted-by":"publisher","DOI":"10.2147\/CCID.S534637"},{"key":"e_1_2_11_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1524-4725.1998.tb04161.x"},{"key":"e_1_2_11_7_1","doi-asserted-by":"publisher","DOI":"10.1007\/s13555-025-01404-3"},{"key":"e_1_2_11_8_1","doi-asserted-by":"publisher","DOI":"10.1111\/dth.13985"},{"key":"e_1_2_11_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jdin.2022.02.010"},{"key":"e_1_2_11_10_1","doi-asserted-by":"publisher","DOI":"10.1002\/lsm.23850"},{"key":"e_1_2_11_11_1","doi-asserted-by":"publisher","DOI":"10.1111\/bjd.12526"},{"issue":"6","key":"e_1_2_11_12_1","first-page":"51","article-title":"Nonablative Fractional Laser Resurfacing in Skin of Color: Evidence\u2010Based Review","volume":"10","author":"Kaushik S. B.","year":"2017","journal-title":"Journal of Clinical and Aesthetic Dermatology"},{"key":"e_1_2_11_13_1","doi-asserted-by":"publisher","DOI":"10.1111\/jdv.14130"},{"key":"e_1_2_11_14_1","doi-asserted-by":"publisher","DOI":"10.1111\/jocd.14296"},{"key":"e_1_2_11_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaad.2011.01.026"},{"key":"e_1_2_11_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.fsc.2022.03.007"},{"key":"e_1_2_11_17_1","doi-asserted-by":"publisher","DOI":"10.1111\/bjd.20660"},{"issue":"2","key":"e_1_2_11_18_1","first-page":"6","article-title":"Assessing Skin Tones in Practice: Results of an International Survey","volume":"13","author":"Dhoonmoon L.","year":"2022","journal-title":"Wounds International"},{"key":"e_1_2_11_19_1","doi-asserted-by":"publisher","DOI":"10.1097\/WON.0000000000000960"},{"key":"e_1_2_11_20_1","doi-asserted-by":"publisher","DOI":"10.1002\/lsm.21079"},{"key":"e_1_2_11_21_1","doi-asserted-by":"publisher","DOI":"10.1080\/14764172.2017.1358453"},{"key":"e_1_2_11_22_1","doi-asserted-by":"publisher","DOI":"10.1002\/lsm.22304"}],"container-title":["Journal of Cosmetic Dermatology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/jocd.70917","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/jocd.70917","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/jocd.70917","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,6,13]],"date-time":"2026-06-13T02:49:55Z","timestamp":1781318995000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/jocd.70917"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,5]]},"references-count":21,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2026,5]]}},"alternative-id":["10.1111\/jocd.70917"],"URL":"https:\/\/doi.org\/10.1111\/jocd.70917","archive":["Portico"],"relation":{},"ISSN":["1473-2130","1473-2165"],"issn-type":[{"value":"1473-2130","type":"print"},{"value":"1473-2165","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,5]]},"assertion":[{"value":"2026-01-09","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-05-04","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-05-12","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e70917"}}