{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,3]],"date-time":"2026-10-03T01:11:01Z","timestamp":1790989861725,"version":"4.1.0"},"reference-count":38,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2026,5,18]],"date-time":"2026-05-18T00:00:00Z","timestamp":1779062400000},"content-version":"vor","delay-in-days":17,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T00:00:00Z","timestamp":1777593600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Cosmetic Dermatology"],"published-print":{"date-parts":[[2026,5]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Topical growth factor\u2010containing cosmeceuticals are widely used to improve visible signs of facial photoaging. Interest has increased in peptide\u2010based alternatives that aim to support similar regenerative pathways without relying on human\u2010derived biologics.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Aim<\/jats:title>\n                    <jats:p>To compare the clinical efficacy, tolerability, and exploratory psychosocial perception outcomes of a topical recombinant epidermal growth factor (REGF), oligopeptide\u20101, serum with a human\u2010derived growth factor (operationally labeled HDEGF) serum.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>This was a 12\u2010week, prospective, randomized, double\u2010blinded, parallel\u2010group pilot trial involving 20 adult female participants (50\u201365\u2009years), predominantly non\u2010Hispanic White with Fitzpatrick Skin Types II and III with moderate to severe facial photoaging. Participants applied their assigned serum twice daily and used a standardized cleanser and sunscreen regimen. Primary endpoints included investigator\u2010rated changes in skin texture and firmness. Secondary endpoints included participant\u2010reported satisfaction. Tertiary endpoints evaluated psychosocial perception using standardized photographs rated by blinded lay evaluators.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Investigator ratings favored the REGF cohort for improvements in skin texture and firmness at later study visits, while global wrinkle severity ratings changed minimally in both cohorts. Participants in the REGF cohort reported higher satisfaction across multiple questionnaire items. In exploratory lay\u2010evaluator assessments, small between\u2010visit differences were observed in select perception domains, including estimated age.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>In this pilot study, the REGF formulation was associated with greater improvement in selected investigator\u2010 and participant\u2010reported outcomes compared with the HDEGF formulation over 12\u2009weeks. Perception\u2010based findings are exploratory and limited by the non\u2010validated nature of the rating instrument. Interpretation is further limited by the small, female\u2010only sample and short follow\u2010up; larger, longer, and more diverse studies are warranted.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/jocd.70927","type":"journal-article","created":{"date-parts":[[2026,5,19]],"date-time":"2026-05-19T05:26:35Z","timestamp":1779168395000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["A Randomized, Double\u2010Blinded Pilot Study Comparing Synthetic Versus Human\u2010Derived Topical Epidermal Growth Factor for Facial Rejuvenation and Psychosocial Perception"],"prefix":"10.1111","volume":"25","author":[{"given":"Brittany","family":"Abud","sequence":"first","affiliation":[{"name":"Department of Otolaryngology \u2010 Head and Neck Surgery University of Illinois College of Medicine  Chicago Illinois USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lander","family":"McGinn","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology \u2010 Head and Neck Surgery University of Illinois College of Medicine  Chicago Illinois USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elvira","family":"Cawthon","sequence":"additional","affiliation":[{"name":"Cawthon Clinical Consulting  Hendersonville Tennessee USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ashley","family":"Pankey","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology \u2010 Head and Neck Surgery University of Illinois College of Medicine  Chicago Illinois USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5088-7995","authenticated-orcid":false,"given":"Nimit","family":"Gandhi","sequence":"additional","affiliation":[{"name":"DeNova Research  Chicago Illinois USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Catherine","family":"Carvajal","sequence":"additional","affiliation":[{"name":"DeNova Research  Chicago Illinois USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Steven","family":"Dayan","sequence":"additional","affiliation":[{"name":"DeNova Research  Chicago Illinois USA"},{"name":"Division of Facial Plastic and Reconstructive Surgery, Department of Otolaryngology University of Illinois at Chicago  Chicago Illinois USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,5,18]]},"reference":[{"key":"e_1_2_13_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/jocd.16229"},{"key":"e_1_2_13_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/s0002\u20109440(10)63337\u20108"},{"key":"e_1_2_13_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1524\u20104725.2006.32132.x"},{"key":"e_1_2_13_5_1","doi-asserted-by":"publisher","DOI":"10.1007\/s13555\u2010022\u201000839\u20102"},{"key":"e_1_2_13_6_1","doi-asserted-by":"publisher","DOI":"10.1097\/DSS.0000000000004436"},{"key":"e_1_2_13_7_1","doi-asserted-by":"publisher","DOI":"10.36849\/jdd.7160"},{"key":"e_1_2_13_8_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1529\u20108019.2007.00149.x"},{"key":"e_1_2_13_9_1","doi-asserted-by":"publisher","DOI":"10.1210\/er.2008\u20100031"},{"key":"e_1_2_13_10_1","doi-asserted-by":"publisher","DOI":"10.1080\/14764170310000817"},{"key":"e_1_2_13_11_1","unstructured":"Verified Market Research \u201cEpidermal Growth Factor (EGF) Market Size Trends & Forecast \u201daccessed July 27 https:\/\/www.verifiedmarketresearch.com\/product\/epidermal\u2010growth\u2010factor\u2010egf\u2010market\/."},{"key":"e_1_2_13_12_1","unstructured":"Z.Draelos \u201cThe Growing Popularity of Growth Factors \u201daccessed July 27 https:\/\/www.dermatologytimes.com\/view\/the\u2010growing\u2010popularity\u2010of\u2010growth\u2010factors."},{"key":"e_1_2_13_13_1","doi-asserted-by":"publisher","DOI":"10.3390\/cosmetics4020016"},{"key":"e_1_2_13_14_1","doi-asserted-by":"publisher","DOI":"10.4103\/JCAS.JCAS_25_20"},{"key":"e_1_2_13_15_1","doi-asserted-by":"publisher","DOI":"10.1111\/iwj.14075"},{"issue":"5","key":"e_1_2_13_16_1","first-page":"613","article-title":"Improved texture and appearance of human facial skin afterdaily topical application of barley produced, synthetic, human\u2010like epidermalgrowth factor (EGF) serum","volume":"11","author":"Schouest J. 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