{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,13]],"date-time":"2026-06-13T03:00:40Z","timestamp":1781319640661,"version":"3.54.1"},"reference-count":28,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2026,5,19]],"date-time":"2026-05-19T00:00:00Z","timestamp":1779148800000},"content-version":"vor","delay-in-days":18,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T00:00:00Z","timestamp":1777593600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Cosmetic Dermatology"],"published-print":{"date-parts":[[2026,5]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Although topical retinoids are first\u2010line therapy for mild\u2010to\u2010moderate acne, treatment\u2010related irritation often limits adherence to long\u2010term therapy. However, dermocosmetic adjuncts may improve treatment outcomes and tolerability.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Aim<\/jats:title>\n                    <jats:p>To assess the efficacy and tolerability of a triple acid\u2010containing serum (TAS) in mild\u2010to\u2010moderate acne.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>An 8\u2010week, open\u2010label, randomized controlled trial of 41 patients with mild\u2010to\u2010moderate acne was performed. The participants received either TAS\u2009+\u2009adapalene gel (AG) (treatment group) or AG alone (control group) for 4\u2009weeks, followed by a 4\u2010week maintenance phase in which AG was discontinued, and TAS was continued only in the experimental group. Lesion counts, Investigator Global Assessment (IGA), microcomedone counts, skin physiological parameters, and VISIA\u2010CR were performed at baseline and 2, 4, and 8\u2009weeks.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>A significantly greater reduction in noninflammatory, inflammatory, and total lesions, IGA scores, and microcomedone counts was observed in the experimental group. The control group showed rebound worsening after AG withdrawal. Improvements in skin physiological parameters were observed in both groups, although without statistical significance. Mild and transient adverse events occurred.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>TAS in combination with AG was shown to improve mild\u2010to\u2010moderate acne with good tolerability and may effectively reduce the recurrence rate when applied as a maintenance treatment post\u2010AG.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/jocd.70929","type":"journal-article","created":{"date-parts":[[2026,5,20]],"date-time":"2026-05-20T01:59:39Z","timestamp":1779242379000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Efficacy and Tolerability of a Triple Acid\u2010Containing Serum Combined With 0.1% Adapalene in Mild\u2010to\u2010Moderate Acne Vulgaris: A Randomized, Open\u2010Label Controlled Trial"],"prefix":"10.1111","volume":"25","author":[{"given":"Jing","family":"LYu","sequence":"first","affiliation":[{"name":"Department of Dermatology Chongqing Hospital of Traditional Chinese Medicine  Chongqing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0004-8263-0774","authenticated-orcid":false,"given":"Jiajia","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Dermatology Chongqing Hospital of Traditional Chinese Medicine  Chongqing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yang","family":"Jiang","sequence":"additional","affiliation":[{"name":"Department of Dermatology Chongqing Hospital of Traditional Chinese Medicine  Chongqing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sha","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Dermatology Chongqing Hospital of Traditional Chinese Medicine  Chongqing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qingchun","family":"Diao","sequence":"additional","affiliation":[{"name":"Department of Dermatology Chongqing Hospital of Traditional Chinese Medicine  Chongqing China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,5,19]]},"reference":[{"key":"e_1_2_12_2_1","doi-asserted-by":"publisher","DOI":"10.1097\/JD9.0000000000000043"},{"key":"e_1_2_12_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/ddg.15272"},{"key":"e_1_2_12_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaad.2015.12.037"},{"key":"e_1_2_12_5_1","doi-asserted-by":"publisher","DOI":"10.1007\/s40257\u2010019\u201000423\u2010z"},{"key":"e_1_2_12_6_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2021.17633"},{"key":"e_1_2_12_7_1","doi-asserted-by":"publisher","DOI":"10.1111\/jdv.20145"},{"key":"e_1_2_12_8_1","doi-asserted-by":"publisher","DOI":"10.1111\/jdv.13579"},{"key":"e_1_2_12_9_1","doi-asserted-by":"publisher","DOI":"10.1111\/ajd.14447"},{"key":"e_1_2_12_10_1","doi-asserted-by":"publisher","DOI":"10.1080\/09546634.2018.1484874"},{"key":"e_1_2_12_11_1","doi-asserted-by":"publisher","DOI":"10.3390\/ma15155413"},{"key":"e_1_2_12_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaad.2023.12.017"},{"key":"e_1_2_12_13_1","doi-asserted-by":"publisher","DOI":"10.3390\/jcm11206079"},{"key":"e_1_2_12_14_1","doi-asserted-by":"publisher","DOI":"10.1155\/2014\/462634"},{"key":"e_1_2_12_15_1","doi-asserted-by":"publisher","DOI":"10.1111\/jdv.15926"},{"key":"e_1_2_12_16_1","doi-asserted-by":"publisher","DOI":"10.1111\/jocd.13168"},{"key":"e_1_2_12_17_1","doi-asserted-by":"publisher","DOI":"10.5114\/dr.2015.53419"},{"key":"e_1_2_12_18_1","doi-asserted-by":"publisher","DOI":"10.1111\/jocd.16238"},{"key":"e_1_2_12_19_1","doi-asserted-by":"publisher","DOI":"10.3390\/molecules28207219"},{"key":"e_1_2_12_20_1","doi-asserted-by":"publisher","DOI":"10.25259\/JCAS_77_2025"},{"key":"e_1_2_12_21_1","doi-asserted-by":"publisher","DOI":"10.1111\/jocd.14281"},{"issue":"4","key":"e_1_2_12_22_1","first-page":"41","article-title":"Evaluation of a Dermocosmetic Serum Containing a Multi\u2010Acid Complex and Niacinamide in Japanese Women With Mild Acne","volume":"18","author":"Igarashi A.","year":"2025","journal-title":"Journal of Clinical and Aesthetic Dermatology"},{"key":"e_1_2_12_23_1","doi-asserted-by":"publisher","DOI":"10.1111\/ics.12729"},{"key":"e_1_2_12_24_1","doi-asserted-by":"publisher","DOI":"10.36849\/JDD.7449"},{"key":"e_1_2_12_25_1","doi-asserted-by":"publisher","DOI":"10.3390\/life12121973"},{"key":"e_1_2_12_26_1","doi-asserted-by":"publisher","DOI":"10.1111\/jdv.18909"},{"key":"e_1_2_12_27_1","doi-asserted-by":"publisher","DOI":"10.2147\/CCID.S474331"},{"key":"e_1_2_12_28_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaad.2025.04.021"},{"issue":"5","key":"e_1_2_12_29_1","first-page":"36","article-title":"Moisturizers for Acne","volume":"7","author":"Chularojanamontri L.","year":"2014","journal-title":"Journal of Clinical and Aesthetic Dermatology"}],"container-title":["Journal of Cosmetic Dermatology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/jocd.70929","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/jocd.70929","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/jocd.70929","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,6,13]],"date-time":"2026-06-13T02:48:38Z","timestamp":1781318918000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/jocd.70929"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,5]]},"references-count":28,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2026,5]]}},"alternative-id":["10.1111\/jocd.70929"],"URL":"https:\/\/doi.org\/10.1111\/jocd.70929","archive":["Portico"],"relation":{},"ISSN":["1473-2130","1473-2165"],"issn-type":[{"value":"1473-2130","type":"print"},{"value":"1473-2165","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,5]]},"assertion":[{"value":"2026-01-21","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-05-08","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-05-19","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e70929"}}