{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T11:56:42Z","timestamp":1790855802816,"version":"4.1.0"},"reference-count":28,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2026,5,26]],"date-time":"2026-05-26T00:00:00Z","timestamp":1779753600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,5,26]],"date-time":"2026-05-26T00:00:00Z","timestamp":1779753600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Cosmetic Dermatology"],"published-print":{"date-parts":[[2026,6]]},"abstract":"ABSTRACT<\/jats:title>\n \n Background<\/jats:title>\n Radiofrequency (RF) devices are employed for noninvasive facial rejuvenation. A novel bimodal RF system delivers monopolar and bipolar energy sequentially within a single shot to enhance efficacy and safety.<\/jats:p>\n <\/jats:sec>\n \n Objectives<\/jats:title>\n To evaluate the safety and efficacy of a bimodal\u2010RF device, DENSITY Noir (Jeisys Med Inc., Seoul, Republic of Korea), for the treatment of lower facial laxity.<\/jats:p>\n <\/jats:sec>\n \n Methods<\/jats:title>\n \n This prospective, open\u2010label clinical study enrolled 26 adults (\n n<\/jats:italic>\n \u2009=\u200926; 30\u201360\u2009years) with mild\u2010to\u2010moderate lower facial laxity. All participants received a single RF treatment session with DENSITY Noir. Outcomes were assessed using investigator and participant global assessments, the Facial Laxity Rating Scale, and 3D Antera imaging for nasolabial fold parameters, together with texture and brown spot measured by VISIA. Safety and tolerability were monitored throughout the study. Statistical analyses included Friedman and Wilcoxon tests, marginal homogeneity tests, and linear mixed\u2010effects model tests.\n <\/jats:p>\n <\/jats:sec>\n \n Results<\/jats:title>\n \n Twenty\u2010three (\n n<\/jats:italic>\n \u2009=\u200923) participants completed follow\u2010up. Nearly half (47.83%) achieved marked improvement (51%\u201375%) on the 6\u2010point global improvement scale at 6\u2009months. Facial laxity ratings significantly improved at 1, 3, and 6\u2009months vs. baseline (\n p<\/jats:italic>\n \u2009<\u20090.001). Antera analysis confirmed significant reductions in nasolabial fold cross\u2010sectional area (baseline: 41.94; 1\u2009month: 38.87; 3\u2009months: 39.63; 6\u2009months: 35.72;\n p<\/jats:italic>\n \u2009=\u20090.02) and wrinkle width (baseline: 1.98\u2009mm; 6\u2009months: 1.85\u2009mm;\n p<\/jats:italic>\n \u2009=\u20090.01). About 78% of participants reported high satisfaction at 6\u2009months. Adverse effects included transient erythema (96.15%), edema (61.53%), and mild procedural pain; all adverse events were minor, transient, and self\u2010limiting.\n <\/jats:p>\n <\/jats:sec>\n \n Conclusions<\/jats:title>\n DENSITY Noir was associated with significant improvement in lower facial laxity with a favorable safety and tolerability profile in this cohort. Further controlled studies are warranted to confirm efficacy and durability.<\/jats:p>\n <\/jats:sec>\n \n Trial Registration<\/jats:title>\n \n ClinicalTrials.gov<\/jats:ext-link>\n identifier: TCTR20250924004\n <\/jats:p>\n <\/jats:sec>","DOI":"10.1111\/jocd.70932","type":"journal-article","created":{"date-parts":[[2026,5,26]],"date-time":"2026-05-26T10:51:21Z","timestamp":1779792681000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Evaluation of a Novel Bimodal\u2010Approach Radiofrequency Device for Lower Facial Tightening in Southeast Asian Patients: An Open\u2010Label Prospective Study"],"prefix":"10.1111","volume":"25","author":[{"given":"Natcha","family":"Chottawornsak","sequence":"first","affiliation":[{"name":"Division of Dermatology, Department of Medicine King Chulalongkorn Memorial Hospital, The Thai Red Cross Society Bangkok Thailand"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Veerarat","family":"Punthitra","sequence":"additional","affiliation":[{"name":"Division of Dermatology, Department of Medicine King Chulalongkorn Memorial Hospital, The Thai Red Cross Society Bangkok Thailand"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dhanyadhorn","family":"Kusonjai","sequence":"additional","affiliation":[{"name":"Division of Dermatology, Department of Medicine King Chulalongkorn Memorial Hospital, The Thai Red Cross Society Bangkok Thailand"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nayanunt","family":"Prinyaroj","sequence":"additional","affiliation":[{"name":"Division of Dermatology, Department of Medicine King Chulalongkorn Memorial Hospital, The Thai Red Cross Society Bangkok Thailand"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4911-9726","authenticated-orcid":false,"given":"Narendra","family":"Kumar","sequence":"additional","affiliation":[{"name":"Global Medical Affairs Jeisys Medical Inc. Seoul Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,5,26]]},"reference":[{"key":"e_1_2_12_2_1","doi-asserted-by":"publisher","DOI":"10.1155\/2022\/8332631"},{"key":"e_1_2_12_3_1","doi-asserted-by":"publisher","DOI":"10.1002\/lsm.23506"},{"key":"e_1_2_12_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.det.2013.09.010"},{"key":"e_1_2_12_5_1","doi-asserted-by":"publisher","DOI":"10.1093\/asjof\/ojaf159"},{"key":"e_1_2_12_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/jocd.15026"},{"key":"e_1_2_12_7_1","doi-asserted-by":"publisher","DOI":"10.1002\/lsm.20925"},{"key":"e_1_2_12_8_1","doi-asserted-by":"publisher","DOI":"10.2147\/CCID.S563513"},{"key":"e_1_2_12_9_1","doi-asserted-by":"publisher","DOI":"10.2147\/CCID.S584912"},{"key":"e_1_2_12_10_1","doi-asserted-by":"publisher","DOI":"10.1111\/jocd.70687"},{"key":"e_1_2_12_11_1","doi-asserted-by":"publisher","DOI":"10.1177\/30499240261424061"},{"key":"e_1_2_12_12_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10103\u2010016\u20102023\u20107"},{"key":"e_1_2_12_13_1","doi-asserted-by":"publisher","DOI":"10.1002\/lsm.22676"},{"key":"e_1_2_12_14_1","doi-asserted-by":"publisher","DOI":"10.1111\/jocd.14898"},{"key":"e_1_2_12_15_1","doi-asserted-by":"publisher","DOI":"10.3109\/14764172.2015.1039035"},{"key":"e_1_2_12_16_1","doi-asserted-by":"publisher","DOI":"10.1111\/srt.13422"},{"key":"e_1_2_12_17_1","doi-asserted-by":"publisher","DOI":"10.1111\/jocd.12689"},{"key":"e_1_2_12_18_1","doi-asserted-by":"publisher","DOI":"10.1002\/lsm.22044"},{"key":"e_1_2_12_19_1","doi-asserted-by":"publisher","DOI":"10.1093\/asjof\/ojaf111"},{"key":"e_1_2_12_20_1","doi-asserted-by":"publisher","DOI":"10.1093\/icvts\/ivy009"},{"key":"e_1_2_12_21_1","doi-asserted-by":"publisher","DOI":"10.1038\/clpt.2011.301"},{"key":"e_1_2_12_22_1","doi-asserted-by":"publisher","DOI":"10.1097\/DSS.0000000000000915"},{"key":"e_1_2_12_23_1","doi-asserted-by":"publisher","DOI":"10.1007\/s13555\u2010022\u201000817\u20108"},{"issue":"11","key":"e_1_2_12_24_1","first-page":"970","article-title":"Patient Satisfaction and Efficacy of Accent Radiofrequency for Facial Skin Wrinkle Reduction","volume":"18","author":"Jaffary F.","year":"2013","journal-title":"Journal of Research in Medical Sciences"},{"key":"e_1_2_12_25_1","doi-asserted-by":"publisher","DOI":"10.1001\/archderm.138.11.1462"},{"key":"e_1_2_12_26_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1524\u20104725.2004.30164.x"},{"key":"e_1_2_12_27_1","doi-asserted-by":"publisher","DOI":"10.1002\/lsm.10127"},{"key":"e_1_2_12_28_1","doi-asserted-by":"publisher","DOI":"10.1002\/lsm.20731"},{"key":"e_1_2_12_29_1","doi-asserted-by":"publisher","DOI":"10.4103\/0019\u20105154.55625"}],"container-title":["Journal of Cosmetic Dermatology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/jocd.70932","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/jocd.70932","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/jocd.70932","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T11:06:49Z","timestamp":1790852809000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/jocd.70932"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,5,26]]},"references-count":28,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2026,6]]}},"alternative-id":["10.1111\/jocd.70932"],"URL":"https:\/\/doi.org\/10.1111\/jocd.70932","archive":["Portico"],"relation":{},"ISSN":["1473-2130","1473-2165"],"issn-type":[{"value":"1473-2130","type":"print"},{"value":"1473-2165","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,5,26]]},"assertion":[{"value":"2026-02-10","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-05-11","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-05-26","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e70932"}}