{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,9]],"date-time":"2026-09-09T01:51:05Z","timestamp":1788918665886,"version":"build-2803163510"},"reference-count":36,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2026,5,19]],"date-time":"2026-05-19T00:00:00Z","timestamp":1779148800000},"content-version":"vor","delay-in-days":18,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T00:00:00Z","timestamp":1777593600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Cosmetic Dermatology"],"published-print":{"date-parts":[[2026,5]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Periorbital rejuvenation presents significant challenges: hyaluronic acid (HA) fillers carry risks of edema and the Tyndall effect, whereas traditional poly\u2010L\u2010lactic acid (PLLA) may lead to nodule formation and delayed inflammatory reactions. To address these limitations, the PLLA\u2010b\u2010poly (ethylene glycol) (PLLA\u2010b\u2010PEG)\/HA composite filler is designed to optimize tissue compatibility and minimize these specific adverse reactions.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>To comprehensively evaluate the physicochemical properties, biocompatibility, and clinical efficacy of this filler for periorbital volume deficiency.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Physicochemical validation included SEM morphology, extrusion force, osmolality, and mechanical support testing. In\u00a0vivo safety and collagenogenesis were assessed via histology in a rabbit model. Additionally, a retrospective clinical study of 15 subjects with infraorbital hollowing evaluated efficacy at 1, 3, and 6 months using the Allergan Infraorbital Hollows Scale (AIHS) and Global Aesthetic Improvement Scale (GAIS). All subjects also underwent clinical safety follow\u2010up through 12\u201314 months; in a subset of subjects, additional 12\u201314\u2010month photographs were available for descriptive review, but these images were not included in the formal efficacy analysis.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      The filler exhibited uniform microspheres, physiological osmolality (302 mOsmol\/kg), and superior mechanical support. In\u00a0vivo, it showed mild inflammation with neocollagenesis. In the retrospective clinical analysis (\n                      <jats:italic>N<\/jats:italic>\n                      =\u200915), the median AIHS score improved significantly from 2.0 at baseline to 1.0 at 6 months (\n                      <jats:italic>p<\/jats:italic>\n                      &lt;\u20090.0001). At 6 months, 93.3% of subjects achieved \u2265\u20091\u2010grade improvement. GAIS improvement rates were stable (\n                      <jats:italic>p<\/jats:italic>\n                      &gt;\u20090.05), with no significant difference between subject and investigator ratings. Adverse events were mild, and no delayed or late\u2010onset adverse events, such as nodules or granulomas, were identified during the extended safety follow\u2010up.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>The PLLA\u2010b\u2010PEG\/HA filler demonstrates unique physicochemical properties and a dual\u2010action mechanism of immediate filling and long\u2010term regeneration, establishing it as a promising, safe treatment for periorbital rejuvenation.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/jocd.70935","type":"journal-article","created":{"date-parts":[[2026,5,20]],"date-time":"2026-05-20T02:00:50Z","timestamp":1779242450000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Cross\u2010Linked Sodium Hyaluronate Filler Containing Poly\u2010L\u2010Lactic Acid\u2010b\u2010Poly (Ethylene Glycol) Microspheres for Periorbital Rejuvenation: A Multimodal Assessment of Physicochemical, Preclinical, and Clinical Performance"],"prefix":"10.1111","volume":"25","author":[{"ORCID":"https:\/\/orcid.org\/0009-0006-5400-579X","authenticated-orcid":false,"given":"Weibin","family":"Chen","sequence":"first","affiliation":[{"name":"Department of Plastic Surgery Yanting County People's Hospital  Mianyang China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guojie","family":"Lei","sequence":"additional","affiliation":[{"name":"Chengdu Tongquetai Medical Cosmetology Hospital  Chengdu China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xia","family":"Lou","sequence":"additional","affiliation":[{"name":"Nanjing Huamei Medical Cosmetology Hospital  Nanjing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qi","family":"Wang","sequence":"additional","affiliation":[{"name":"Beijing Yestar Medical Cosmetology Hospital  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fang","family":"Yang","sequence":"additional","affiliation":[{"name":"Shenzhen Yestar Medical Cosmetology Hospital  Shenzhen China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kun","family":"Zhang","sequence":"additional","affiliation":[{"name":"Beijing Engineering Lab of Neo\u2010Biodegradable Materials  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tong","family":"He","sequence":"additional","affiliation":[{"name":"Beijing Engineering Lab of Neo\u2010Biodegradable Materials  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guangyu","family":"Chen","sequence":"additional","affiliation":[{"name":"Beijing Engineering Lab of Neo\u2010Biodegradable Materials  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yang","family":"Ling","sequence":"additional","affiliation":[{"name":"Beijing Engineering Lab of Neo\u2010Biodegradable Materials  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shiwei","family":"Wang","sequence":"additional","affiliation":[{"name":"Beijing Engineering Lab of Neo\u2010Biodegradable Materials  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,5,19]]},"reference":[{"key":"e_1_2_13_2_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00266-025-04764-5"},{"key":"e_1_2_13_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/jocd.14491"},{"key":"e_1_2_13_4_1","doi-asserted-by":"publisher","DOI":"10.21037\/apm-20-1822"},{"key":"e_1_2_13_5_1","doi-asserted-by":"publisher","DOI":"10.5114\/ada.2016.61607"},{"issue":"2","key":"e_1_2_13_6_1","article-title":"Anatomy\u2010Based Filler Injection: Treatment Techniques for Supraorbital Hollowness and Charming Roll","volume":"15","author":"Hong G. 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