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Meaning serves as a mediating variable in both psychological and physical health.<\/jats:p><\/jats:sec><jats:sec><jats:title>Design and methods<\/jats:title><jats:p>The study employed a cross\u2010sectional design. Data were collected in 2008 and 2009 using the <jats:styled-content style=\"fixed-case\">QLQ<\/jats:styled-content>\u2010C15\u2010<jats:styled-content style=\"fixed-case\">PAL<\/jats:styled-content> quality\u2010of\u2010life questionnaire, the purpose\u2010in\u2010life test and the Hospital Anxiety and Depression Scale. A total of 250 cognitively intact nursing\u2010home patients who met the inclusion criteria were approached and 202 attended.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The prevalence of symptoms was fairly high, with fatigue (57%), pain (49%), constipation (43%) and dyspnoea (41%) as the most frequent physical symptoms, while 30% were depressed and 12% had anxiety. Significant correlations between meaning\u2010in\u2010life and symptom severity were displayed.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>The level of symptom severity among cognitively intact nursing\u2010home patients is high, requiring highly competent staff nurses. Meaning\u2010in\u2010life might be an important resource in relation to a patient's physical and emotional health and global well\u2010being.<\/jats:p><\/jats:sec><jats:sec><jats:title>Relevance to clinical practice<\/jats:title><jats:p>Facilitating patients' meaning\u2010in\u2010life might help reducing symptom severity and fostering quality of life in cognitively intact nursing\u2010home patients. 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