{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,1]],"date-time":"2026-04-01T00:08:18Z","timestamp":1775002098964,"version":"3.50.1"},"reference-count":46,"publisher":"Wiley","issue":"19-20","license":[{"start":{"date-parts":[[2014,1,7]],"date-time":"2014-01-07T00:00:00Z","timestamp":1389052800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100001868","name":"National Science Council of Taiwan","doi-asserted-by":"crossref","award":["94-2314-B-182-025"],"award-info":[{"award-number":["94-2314-B-182-025"]}],"id":[{"id":"10.13039\/501100001868","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Clinical Nursing"],"published-print":{"date-parts":[[2014,10]]},"abstract":"<jats:sec><jats:title>Aims and objectives<\/jats:title><jats:p>To investigate the trajectory of weight change in Taiwanese women with breast cancer after starting chemotherapy and the impact of chemotherapy regimens on weight change while controlling for age, menopausal status, body mass index, lymph node involvement and changes in habits of dietary fat intake and exercise.<\/jats:p><\/jats:sec><jats:sec><jats:title>Background<\/jats:title><jats:p>Weight gain after adjuvant chemotherapy in women with breast cancer has negative impact on health outcomes.<\/jats:p><\/jats:sec><jats:sec><jats:title>Design<\/jats:title><jats:p>Longitudinal, clinical observational study.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Weights were repeatedly measured in 147 women with breast cancer stages I\u2013<jats:styled-content style=\"fixed-case\">III<\/jats:styled-content>. Hierarchical linear modelling was used to analyse these longitudinal data.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The overall pattern of weight change was a cubic form beginning with a mean of 56\u00b79\u00a0kg before chemotherapy. It gradually increased to 59\u00b74\u00a0kg at 8\u00b75\u00a0months after the first chemotherapy followed by a decrease to 58\u00b75\u00a0kg at 21\u00b75\u00a0months. During the last 2\u00b75\u00a0months, weight increased slightly and never returned to the initial level. After controlling for confounders, steeper weight change was observed among women receiving cyclophosphamide, methotrexate and fluorouracil. The highest weight gain in the cyclophosphamide, methotrexate and fluorouracil group was 2\u00b79\u00a0kg (5%) vs. 0\u00b79\u00a0kg (1%) in the anthracycline\u2010based group.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>The trajectory of body weight change within two years after chemotherapy shows a trend of gradual ascent, followed by a small decline and a slight increase in the last 2\u00b75\u00a0months. The chemotherapy regimen can predict the trend after controlling for other confounders; women on cyclophosphamide, methotrexate and fluorouracil have a steeper weight change.<\/jats:p><\/jats:sec><jats:sec><jats:title>Relevance to clinical practice<\/jats:title><jats:p>Nurses can inform women with breast cancer about the expected changes in body weight after chemotherapy to reduce their uncertainty. Future studies on effective interventions to minimise chemotherapy\u2010induced weight gain are needed.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jocn.12521","type":"journal-article","created":{"date-parts":[[2014,1,7]],"date-time":"2014-01-07T10:34:09Z","timestamp":1389090849000},"page":"2757-2768","source":"Crossref","is-referenced-by-count":16,"title":["Weight change trajectory in women with breast cancer receiving chemotherapy and the effect of different regimens"],"prefix":"10.1111","volume":"23","author":[{"given":"Li\u2010Ni","family":"Liu","sequence":"first","affiliation":[{"name":"Department of Nursing Fu Jen Catholic University New Taipei City Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fur\u2010Hsing","family":"Wen","sequence":"additional","affiliation":[{"name":"Department of International Business Soochow University Taipei 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