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Treatment options include conservative management, revascularisation or amputation. However, the links between treatment decisions and quality of life require further investigation.<\/jats:p><\/jats:sec><jats:sec><jats:title>Design<\/jats:title><jats:p>The framework for this integrative review was the peripheral arterial disease\u2010specific health\u2010related quality of life domains identified by Treat\u2010Jacobson <jats:italic>et\u00a0al<\/jats:italic>.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The literature expanded and refined Treat\u2010Jacobson's framework by modifying the characteristics to better describe health\u2010related quality of life in critical limb ischaemia.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Given that critical limb ischaemia is a highly individualised situation with powerful health\u2010related quality of life implications, further research focusing on patient and family\u2010centred decision\u2010making relating to therapeutic options and advanced care planning is required.<\/jats:p><\/jats:sec><jats:sec><jats:title>Relevance to clinical practice<\/jats:title><jats:p>A critical limb ischaemia\u2010specific, health\u2010related quality of life tool is required to capture both the unique characteristics of this disorder, and the outcomes for active or conservative care among this complex group of patients.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jocn.13623","type":"journal-article","created":{"date-parts":[[2016,11,3]],"date-time":"2016-11-03T10:47:49Z","timestamp":1478170069000},"page":"2826-2844","source":"Crossref","is-referenced-by-count":10,"title":["An integrative review of health\u2010related quality of life in patients with critical limb ischaemia"],"prefix":"10.1111","volume":"26","author":[{"given":"Susan","family":"Monaro","sequence":"first","affiliation":[{"name":"Concord Repatriation General Hospital Concord NSW Australia"},{"name":"Sydney Nursing School University of Sydney Sydney NSW Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sandra","family":"West","sequence":"additional","affiliation":[{"name":"Sydney Nursing School University of Sydney Sydney NSW Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Janice","family":"Gullick","sequence":"additional","affiliation":[{"name":"Sydney Nursing School University of Sydney Sydney NSW Australia"},{"name":"Sydney Local Health District Sydney NSW Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2017,3,20]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2012.216237"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1078-5884(96)80077-3"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jvs.2007.04.039"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1062-0303(97)90049-2"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.3113\/FAI.2008.1074"},{"key":"e_1_2_10_7_1","first-page":"25","article-title":"Diabetic foot ulcer pain: the hidden burden (Part two)","volume":"11","author":"Bradbury SE","year":"2011","journal-title":"European Wound Management Association Journal"},{"key":"e_1_2_10_8_1","unstructured":"S Brahmanandam L Messina M Belkin M Conte L Nguyen 2009 166 167"},{"key":"e_1_2_10_9_1","first-page":"62","article-title":"Justification of intervention for limb\u2010threatening ischemia: a surgical decision analysis","volume":"7","author":"Brothers T","year":"1999","journal-title":"Vascular"},{"key":"e_1_2_10_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1062-0303(96)80025-2"},{"key":"e_1_2_10_11_1","unstructured":"CDC(2011)Health Related Quality of Life.Centers for Disease Control and Prevention Atlanta GA. 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