{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T01:13:52Z","timestamp":1787015632246,"version":"build-2736575974"},"reference-count":27,"publisher":"Wiley","issue":"5-6","license":[{"start":{"date-parts":[[2018,1,23]],"date-time":"2018-01-23T00:00:00Z","timestamp":1516665600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100007136","name":"Secretar\u00eda de Estado de Investigaci\u00f3n, Desarrollo e Innovaci\u00f3n","doi-asserted-by":"publisher","award":["PSI2014\u201052962\u2010P"],"award-info":[{"award-number":["PSI2014\u201052962\u2010P"]}],"id":[{"id":"10.13039\/501100007136","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Clinical Nursing"],"published-print":{"date-parts":[[2018,3]]},"abstract":"<jats:sec>\n                    <jats:title>Aims and objectives<\/jats:title>\n                    <jats:p>To investigate the clinical benefits of using humidification in low\u2010flow oxygen therapy. Specific objectives were to investigate via an assessment of the number of nasal lavages whether humidification can help to decrease the nasal mucus viscosity, to determine whether it can relieve feeding difficulties by comparing the weight gain in infants, to ascertain whether it can relieve respiratory distress by assessing the heart and respiratory rates and contribute to improved clinical outcomes, measured by the length of stay and oxygen requirements.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>There is no evidence to support the use of humidification in low\u2010flow oxygen therapy as a usual clinical practice in the management of bronchiolitis.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Design<\/jats:title>\n                    <jats:p>A controlled quasi\u2010experimental study.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>A total of 97 infants were included, aged \u22646\u00a0months, with bronchiolitis, low\u2010flow oxygen therapy and bronchodilators nebulised with hypertonic saline 3%. Data from the control group (nonhumidified) were gathered from 2010\u20132012 (49 infants), and data from the group with humidification from 2012\u20132014 (48 infants). Linear and Poisson regressions were performed adjusting for relevant characteristics of patients.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Humidification was shown to be associated with significant reductions in the number of nasal lavages in infants with Sant Joan de D\u00e9u Bronchiolitis Scores of\n                      <jats:styled-content style=\"fixed-case\">BROSJOD<\/jats:styled-content>\n                      \u22647, in the heart rate of infants with mixed bronchodilators treatment, and in the length of stay and oxygen requirements of infants with Score\n                      <jats:styled-content style=\"fixed-case\">BROSJOD<\/jats:styled-content>\n                      \u22645. No differences in weight and respiratory rate were found.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Humidification in low\u2010flow oxygen therapy is an effective nursing intervention to improve the clinical outcomes of infants with mild\u2013moderate bronchiolitis.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Relevance to clinical practice<\/jats:title>\n                    <jats:p>Humidifying the nasal mucosa can help to reduce the need for professional procedures, oxygen requirements and hospitalisation length. Further research into the economic savings involved is recommended.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/jocn.14140","type":"journal-article","created":{"date-parts":[[2017,10,27]],"date-time":"2017-10-27T06:41:10Z","timestamp":1509086470000},"page":"1125-1133","source":"Crossref","is-referenced-by-count":7,"title":["Benefits of the humidified low\u2010flow oxygen therapy in infants with mild\u2013moderate bronchiolitis"],"prefix":"10.1111","volume":"27","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5494-3325","authenticated-orcid":false,"given":"Sonia","family":"Lorente S\u00e1nchez","sequence":"first","affiliation":[{"name":"Department of Psychobiology and Methodology of Health Science Universitat Aut\u00f2noma de Barcelona, UAB Bellaterra Spain"},{"name":"Pediatric Department Hospital de Terrassa Consorci Sanitari de Terrassa Terrassa Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rebeca","family":"Gimeno","sequence":"additional","affiliation":[{"name":"Pediatric Department Hospital de Terrassa Consorci Sanitari de Terrassa Terrassa Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Josep\u2010Maria","family":"Losilla","sequence":"additional","affiliation":[{"name":"Department of Psychobiology and Methodology of Health Science Universitat Aut\u00f2noma de Barcelona, UAB Bellaterra Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sandra","family":"Garz\u00f3n","sequence":"additional","affiliation":[{"name":"Pediatric Department Hospital de Terrassa Consorci Sanitari de Terrassa Terrassa Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jaume","family":"Vives","sequence":"additional","affiliation":[{"name":"Department of Psychobiology and Methodology of Health Science Universitat Aut\u00f2noma de Barcelona, UAB Bellaterra Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2018,1,23]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1542\/peds.2014-2742"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1002\/ppul.23546"},{"issue":"3","key":"e_1_2_9_4_1","first-page":"129","article-title":"Breathing easy: Implementing a bronchiolitis protocol","volume":"37","author":"Black A.","year":"2011","journal-title":"Pediatric Nursing"},{"key":"e_1_2_9_5_1","unstructured":"Bronchiolitis Guideline Team Cincinnati Children's Hospital Medical Center. (2005).Evidence based clinical practice guideline for medical management of bronchiolitis in infants 1 year of age or less presenting with a first time episode.http:\/\/www.cincinnatichildrens.org\/svc\/alpha\/h\/health-policy\/ev-based\/bronchiolitis.htm Guideline 1 pages1\u201313."},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.4187\/respcare.01681"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1186\/1824-7288-36-67"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1542\/peds.2008-3256"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.rmed.2009.04.007"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.1111\/apa.13931"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.5694\/j.1326-5377.2004.tb05993.x"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.1155\/2017\/2565397"},{"key":"e_1_2_9_13_1","doi-asserted-by":"publisher","DOI":"10.4172\/2155-9627.1000281"},{"key":"e_1_2_9_14_1","doi-asserted-by":"publisher","DOI":"10.1542\/peds.2010-0507"},{"key":"e_1_2_9_15_1","volume-title":"IBM SPSS Statistics for Windows, Version 20.0","author":"IBM Corp","year":"2011"},{"key":"e_1_2_9_16_1","doi-asserted-by":"publisher","DOI":"10.1586\/eri.10.140"},{"issue":"2","key":"e_1_2_9_17_1","first-page":"241","article-title":"Comparison of epinephrine to salbutamol in acute bronchiolitis","volume":"22","author":"Modaressi M.","year":"2012","journal-title":"Iranian Journal of Pediatrics"},{"key":"e_1_2_9_18_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1442-200X.2010.03274.x"},{"key":"e_1_2_9_19_1","doi-asserted-by":"publisher","DOI":"10.1186\/1757-7241-22-23"},{"key":"e_1_2_9_20_1","unstructured":"Saskatoon Health Region Nursing Practice Committee. (2006).Oxygen administration policies & procedures. Retrieved fromhttps:\/\/www.saskatoonhealthregion.ca\/about\/NursingManual\/1115.pdf"},{"key":"e_1_2_9_21_1","doi-asserted-by":"publisher","DOI":"10.1097\/MOP.0000000000000090"},{"key":"e_1_2_9_22_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0022425"},{"key":"e_1_2_9_23_1","unstructured":"Tyco Healthcare Group. (2004).Humidification nebulisation oxygen therapy. What is Respiflo?Retrieved fromhttp:\/\/www.gulcanlarmedikal.com.tr\/pdf\/coviden\/OxygenTherapy.pdf"},{"key":"e_1_2_9_24_1","first-page":"1","article-title":"Steam inhalation or humidified oxygen for acute bronchiolitis in children up to three years of age (Review)","volume":"1","author":"Umoren R.","year":"2011","journal-title":"The Cochrane Database of Systematic Reviews"},{"key":"e_1_2_9_25_1","unstructured":"Villanueva G. &Bay\u00f3n J.(2013).Evaluation of bubble humidification systems in low\u2010flow oxygen therapy.Systematic review and cost analysis. 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