{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,5,14]],"date-time":"2025-05-14T01:33:56Z","timestamp":1747186436766,"version":"3.40.5"},"reference-count":38,"publisher":"Wiley","issue":"19-20","license":[{"start":{"date-parts":[[2019,6,4]],"date-time":"2019-06-04T00:00:00Z","timestamp":1559606400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Journal of Clinical Nursing"],"published-print":{"date-parts":[[2019,10]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Aims and objectives<\/jats:title><jats:p>To evaluate the necessity of oxygen humidification for low\u2010flow oxygen therapy in children with Pierre\u2013Robin syndrome.<\/jats:p><\/jats:sec><jats:sec><jats:title>Background<\/jats:title><jats:p>Whether to carry out humidification or not in the low\u2010flow oxygen delivery remains unclear, and currently, there is no published study on this issue in the population of children. Therefore, it is necessary to conduct more studies to elucidate this issue.<\/jats:p><\/jats:sec><jats:sec><jats:title>Design<\/jats:title><jats:p>A randomised controlled trial.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We attempt to report this randomised controlled trial to comply with the Standard Protocol Items: Recommendations for Interventional Trials (SPIRIT). 188 children with Pierre\u2013Robin syndrome will be expected to inclusion. The participants will be randomly divided into the humidified group (<jats:italic>n<\/jats:italic>\u00a0=\u00a094) and nonhumidified group (<jats:italic>n<\/jats:italic>\u00a0=\u00a094) at a ratio of 1:1. For humidified group, the oxygen will be routinely humidified with disposable bottle containing sterile water, whereas for nonhumidified group, the oxygen will not be humidified. Average arterial oxygen partial pressure (PaO<jats:sub>2<\/jats:sub>) and carbon dioxide partial pressure (PaCO<jats:sub>2<\/jats:sub>), incidence of ventilator\u2010associated pneumonia (VAP), nasal cavity dryness, nasal mucosal bleeding and bacterial contamination of the humidified bottle, the cost of nasal oxygen therapy and duration of ICU stay are collected and analysed.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The study is planned to start in May 2019, and the results will be expected in July 2020.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>This study is expected to provide a credible evidence on the necessity of routine oxygen humidification in low\u2010flow oxygen delivery.<\/jats:p><\/jats:sec><jats:sec><jats:title>Relevance to clinical practice<\/jats:title><jats:p>Understanding the role of oxygen humidification and no humidification for low\u2010flow oxygen therapy in the population of children is beneficial to the nursing care of healthcare providers in clinical setting.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jocn.14943","type":"journal-article","created":{"date-parts":[[2019,6,4]],"date-time":"2019-06-04T17:18:33Z","timestamp":1559668713000},"page":"3522-3528","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Humidified versus nonhumidified low\u2010flow oxygen therapy in children with Pierre\u2010Robin syndrome: Study protocol for a randomised controlled trial"],"prefix":"10.1111","volume":"28","author":[{"given":"Zunjia","family":"Wen","sequence":"first","affiliation":[{"name":"Children's Hospital of Nanjing Medical University Nanjing China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xin","family":"Zhang","sequence":"additional","affiliation":[{"name":"Children's Hospital of Nanjing Medical University Nanjing China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yingfei","family":"Liu","sequence":"additional","affiliation":[{"name":"Children's Hospital of Nanjing Medical University Nanjing China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yan","family":"Li","sequence":"additional","affiliation":[{"name":"Children's Hospital of Nanjing Medical University Nanjing China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiaoyan","family":"Li","sequence":"additional","affiliation":[{"name":"Children's Hospital of Nanjing Medical University Nanjing China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7543-9876","authenticated-orcid":false,"given":"Li","family":"Wei","sequence":"additional","affiliation":[{"name":"Children's Hospital of Nanjing Medical University Nanjing China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2019,6,21]]},"reference":[{"issue":"8","key":"e_1_2_11_2_1","first-page":"1063","article-title":"AARC clinical practice guideline. Oxygen therapy in the home or alternate site health care facility\u20132007 revision & update","volume":"52","author":"AARC","year":"2007","journal-title":"Respir Care"},{"issue":"2","key":"e_1_2_11_3_1","first-page":"305","article-title":"Humidification in the intensive care unit","volume":"4","author":"Branson R. D.","year":"1998","journal-title":"Respiratory Care Clinics of North America"},{"issue":"1","key":"e_1_2_11_4_1","first-page":"88","article-title":"A systematic review of the efficacy of continuing low\u2010flow non\u2010humidified nasal cannula oxygen therapy","volume":"16","author":"Chu S.","year":"2016","journal-title":"Chinese Nursing Management"},{"key":"e_1_2_11_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijporl.2015.01.035"},{"key":"e_1_2_11_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.chest.2016.03.035"},{"key":"e_1_2_11_7_1","doi-asserted-by":"publisher","DOI":"10.1097\/SCS.0000000000004178"},{"key":"e_1_2_11_8_1","doi-asserted-by":"publisher","DOI":"10.4103\/0970-2113.99248"},{"issue":"12","key":"e_1_2_11_9_1","first-page":"18","article-title":"Clinical application of non\u2010humidified continuous low\u2010flow oxygen delivery with nasal cannula","volume":"29","author":"Hao X.","year":"2017","journal-title":"Guangxi Medical Journal"},{"key":"e_1_2_11_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.annemergmed.2015.11.012"},{"key":"e_1_2_11_11_1","doi-asserted-by":"publisher","DOI":"10.1097\/PRS.0000000000003167"},{"key":"e_1_2_11_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.injury.2018.03.037"},{"key":"e_1_2_11_13_1","doi-asserted-by":"publisher","DOI":"10.1378\/chest.08-0679"},{"issue":"1","key":"e_1_2_11_14_1","first-page":"31","article-title":"A comparison study on the respiratory symptoms between patients receiving low\u2010to\u2010mid flow humidified and dry oxygen by nasal cannula","volume":"45","author":"Li L.","year":"2010","journal-title":"Chinese Journal of Nursing"},{"issue":"4","key":"e_1_2_11_15_1","first-page":"12","article-title":"Survey on the bacterial contamination of clinical oxygen humidifying bottles","volume":"27","author":"Li W.","year":"2010","journal-title":"Chinese Journal of Disinfection"},{"volume-title":"Medical statistics guidance and application of SPSS17.0","year":"2015","author":"Liu J.","key":"e_1_2_11_16_1"},{"key":"e_1_2_11_17_1","doi-asserted-by":"publisher","DOI":"10.1111\/jocn.14140"},{"issue":"10","key":"e_1_2_11_18_1","first-page":"12","article-title":"Comparison on the effects of medium and low flow non\u2010humidified and humidified oxygen in patients after orthopedic surgery","volume":"20","author":"Lou L.","year":"2016","journal-title":"Journal of Clinical Medicine in Practice"},{"issue":"1","key":"e_1_2_11_19_1","first-page":"26","article-title":"Progress in application of nasal oxygen therapy in adult emergency patients","volume":"25","author":"Lu W.","year":"2018","journal-title":"Journal of Chinese Medicine and Western Medicine in Emergency"},{"issue":"8","key":"e_1_2_11_20_1","first-page":"21","article-title":"Evidence\u2010based practice of middle\u2010low\u2010flow non\u2010humidified nasal cannula oxygen therapy for patients in department of respiration","volume":"35","author":"Ma Q.","year":"2018","journal-title":"Nursing Journal of Chinese People's Liberation Army"},{"key":"e_1_2_11_21_1","doi-asserted-by":"publisher","DOI":"10.4187\/respcare.03423"},{"issue":"2","key":"e_1_2_11_22_1","first-page":"138","article-title":"Is it necessary to humidify inhaled low\u2010flow oxygen or low\u2010concentration oxygen?","volume":"42","author":"Miyamoto K.","year":"2004","journal-title":"Nihon Kokyuki Gakkai Zasshi"},{"issue":"4","key":"e_1_2_11_23_1","first-page":"255","article-title":"Guideline for the diagnosis, prevention and treatment of paediatric ventilator\u2010associated pneumonia","volume":"99","author":"Morrow B. M.","year":"2009","journal-title":"South African Medical Journal"},{"key":"e_1_2_11_24_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1442-200X.2010.03274.x"},{"issue":"5","key":"e_1_2_11_25_1","first-page":"1","article-title":"Bacterial contamination of three types of oxygen humidifier reservoirs used in low to medium flow oxygen therapy","volume":"29","author":"Ning X.","year":"2014","journal-title":"Journal of Nursing Science"},{"issue":"6","key":"e_1_2_11_26_1","first-page":"vi1","article-title":"BTS guideline for emergency oxygen use in adult patients","volume":"63","author":"O'Driscoll B. R.","year":"2008","journal-title":"Thorax"},{"issue":"1","key":"e_1_2_11_27_1","first-page":"172","article-title":"Advances in nursing research of oxygenation with nasal cannula","volume":"6","author":"Peng J.","year":"2013","journal-title":"Journal of Clinical Rational Medicine"},{"issue":"2","key":"e_1_2_11_28_1","first-page":"263","article-title":"The effect of humidification on the incidence of ventilator\u2010associated pneumonia","volume":"12","author":"Ricard J. D.","year":"2006","journal-title":"Respiratory Care Clinics of North America"},{"issue":"2","key":"e_1_2_11_29_1","first-page":"233","article-title":"Consequences of under\u2010 and over\u2010humidification","volume":"12","author":"Sottiaux T. M.","year":"2006","journal-title":"Respiratory Care Clinics of North America"},{"issue":"9","key":"e_1_2_11_30_1","first-page":"1097","article-title":"Systematic evaluation of clinical effects of humidification and non\u2010humidification in low\u2010flow nasal oxygen delivery","volume":"26","author":"Sun X.","year":"2016","journal-title":"Chinese Journal of Evidence\u2010based Medicine"},{"key":"e_1_2_11_31_1","doi-asserted-by":"publisher","DOI":"10.1097\/SCS.0000000000002721"},{"key":"e_1_2_11_32_1","doi-asserted-by":"publisher","DOI":"10.1542\/peds.2004-2411"},{"key":"e_1_2_11_33_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11908-015-0496-3"},{"key":"e_1_2_11_34_1","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1099-0496(199608)22:2<125::AID-PPUL8>3.0.CO;2-P"},{"key":"e_1_2_11_35_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0203332"},{"key":"e_1_2_11_36_1","doi-asserted-by":"publisher","DOI":"10.1111\/jan.13323"},{"key":"e_1_2_11_37_1","doi-asserted-by":"publisher","DOI":"10.1097\/ACO.0000000000000682"},{"issue":"17","key":"e_1_2_11_38_1","first-page":"1310","article-title":"The practice of evidence\u2010based nursing of non\u2010humidified of continuing nasal cannula oxygen therapy","volume":"33","author":"Xing X.","year":"2017","journal-title":"Chinese Journal of Practical Nursing"},{"key":"e_1_2_11_39_1","doi-asserted-by":"publisher","DOI":"10.4187\/respcare.02878"}],"container-title":["Journal of Clinical Nursing"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fjocn.14943","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/jocn.14943","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/jocn.14943","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/jocn.14943","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,7]],"date-time":"2023-09-07T04:48:49Z","timestamp":1694062129000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/jocn.14943"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,6,21]]},"references-count":38,"journal-issue":{"issue":"19-20","published-print":{"date-parts":[[2019,10]]}},"alternative-id":["10.1111\/jocn.14943"],"URL":"https:\/\/doi.org\/10.1111\/jocn.14943","archive":["Portico"],"relation":{},"ISSN":["0962-1067","1365-2702"],"issn-type":[{"type":"print","value":"0962-1067"},{"type":"electronic","value":"1365-2702"}],"subject":[],"published":{"date-parts":[[2019,6,21]]},"assertion":[{"value":"2019-02-04","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2019-05-26","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2019-06-21","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}