{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,31]],"date-time":"2026-08-31T23:38:36Z","timestamp":1788219516402,"version":"build-2803163510"},"reference-count":113,"publisher":"Wiley","issue":"9-10","license":[{"start":{"date-parts":[[2022,1,10]],"date-time":"2022-01-10T00:00:00Z","timestamp":1641772800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100003725","name":"National Research Foundation of Korea","doi-asserted-by":"publisher","award":["2018R1D1A1B07043690"],"award-info":[{"award-number":["2018R1D1A1B07043690"]}],"id":[{"id":"10.13039\/501100003725","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Journal of Clinical Nursing"],"published-print":{"date-parts":[[2023,5]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Aims and objectives<\/jats:title><jats:p>To systematically review the existing literature reporting symptoms in childhood and adolescent and young adult cancer survivors and to meta\u2010analyse the pooled prevalence of symptoms.<\/jats:p><\/jats:sec><jats:sec><jats:title>Background<\/jats:title><jats:p>Cancer survivors experience various symptoms caused by cancer treatments and their late effects. These symptoms are associated with adverse health outcomes. However, estimates of symptom prevalence vary largely, and no comprehensive review of symptoms has been conducted for childhood and adolescent and young adult cancer survivors.<\/jats:p><\/jats:sec><jats:sec><jats:title>Design<\/jats:title><jats:p>A systematic review.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>This systematic review is registered in PROSPERO registry and was performed following the PRISMA guidelines. PubMed, EMBASE, Cochrane Library, Web of Science, Scopus and CINAHL were searched up to July 2021. Three investigators assessed the eligibility of studies, extracted data and performed quality assessment. The pooled prevalence of symptoms was calculated using a random\u2010effect model. Subgroup analysis was conducted to identify heterogeneity.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Sixty\u2010one studies were used to synthesise symptom prevalence, involving 114,184 participants. There were 24 physical symptoms and 10 psychological symptoms reported in two or more studies. The most studied physical symptoms were fatigue and sleep disturbance, and the most studied psychological symptoms were anxiety and depression. Among physical symptoms, drowsiness had the highest prevalence, followed by dry mouth and fatigue. Among psychological symptoms, worry and nervousness had the highest prevalence, followed by difficulty concentrating.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Physical and psychological symptoms are common in the target population. This review provides an up\u2010to\u2010date overview of symptom prevalence, identifying areas for future research.<\/jats:p><\/jats:sec><jats:sec><jats:title>Relevance to clinical practice<\/jats:title><jats:p>Education about possible symptoms related to cancer and its treatment should be given while in treatment. Symptoms should also be monitored throughout the survivorship period. Nurses have a critical role in identifying and making referrals for psychological symptoms as well as promoting preventative strategies that enhance well\u2010being.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jocn.16201","type":"journal-article","created":{"date-parts":[[2022,1,11]],"date-time":"2022-01-11T04:39:07Z","timestamp":1641875947000},"page":"1768-1794","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":27,"title":["A systematic review and pooled prevalence of symptoms among childhood and adolescent and young adult cancer survivors"],"prefix":"10.1111","volume":"32","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0501-8456","authenticated-orcid":false,"given":"Hye Chong","family":"Hong","sequence":"first","affiliation":[{"name":"Department of Nursing Chung\u2010Ang University  Seoul Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5151-0559","authenticated-orcid":false,"given":"Ari","family":"Min","sequence":"additional","affiliation":[{"name":"Department of Nursing Chung\u2010Ang University  Seoul Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4042-8346","authenticated-orcid":false,"given":"Young Man","family":"Kim","sequence":"additional","affiliation":[{"name":"College of Nursing \u2219 Research Institute of Nursing Science Jeonbuk National University  Jeonju\u2010si Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2022,1,10]]},"reference":[{"key":"e_1_2_13_2_1","doi-asserted-by":"publisher","DOI":"10.1002\/pbc.26840"},{"key":"e_1_2_13_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jad.2018.07.035"},{"key":"e_1_2_13_4_1","volume-title":"Key statistics for childhood cancers","author":"American Cancer Society","year":"2021"},{"key":"e_1_2_13_5_1","volume-title":"Cancer treatment & survivorship facts & figures 2010\u20132021","author":"American Cancer Society","year":"2021"},{"key":"e_1_2_13_6_1","doi-asserted-by":"publisher","DOI":"10.1002\/pbc.27356"},{"key":"e_1_2_13_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jad.2020.09.129"},{"key":"e_1_2_13_8_1","doi-asserted-by":"publisher","DOI":"10.1111\/ecc.12561"},{"key":"e_1_2_13_9_1","doi-asserted-by":"publisher","DOI":"10.1002\/pon.3286"},{"key":"e_1_2_13_10_1","doi-asserted-by":"publisher","DOI":"10.1182\/asheducation\u20102018.1.146"},{"key":"e_1_2_13_11_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamapediatrics.2019.1712"},{"key":"e_1_2_13_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140\u20106736(12)60240\u20102"},{"key":"e_1_2_13_13_1","doi-asserted-by":"publisher","DOI":"10.2307\/2533446"},{"key":"e_1_2_13_14_1","doi-asserted-by":"publisher","DOI":"10.1002\/pbc.25773"},{"key":"e_1_2_13_15_1","doi-asserted-by":"publisher","DOI":"10.1002\/pbc.21337"},{"key":"e_1_2_13_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jsxm.2020.06.005"},{"key":"e_1_2_13_17_1","doi-asserted-by":"publisher","DOI":"10.1111\/jsm.12193"},{"key":"e_1_2_13_18_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00520\u2010016\u20103150\u20101"},{"key":"e_1_2_13_19_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2016.66.4789"},{"key":"e_1_2_13_20_1","doi-asserted-by":"publisher","DOI":"10.1111\/add.14439"},{"key":"e_1_2_13_21_1","doi-asserted-by":"publisher","DOI":"10.1002\/cncr.28385"},{"key":"e_1_2_13_22_1","doi-asserted-by":"publisher","DOI":"10.1002\/cam4.1936"},{"key":"e_1_2_13_23_1","doi-asserted-by":"publisher","DOI":"10.1097\/00002820\u2010199310000\u201000003"},{"key":"e_1_2_13_24_1","doi-asserted-by":"publisher","DOI":"10.1177\/1043454212451367"},{"key":"e_1_2_13_25_1","doi-asserted-by":"publisher","DOI":"10.1002\/cncr.25797"},{"key":"e_1_2_13_26_1","doi-asserted-by":"publisher","DOI":"10.1002\/pon.5647"},{"key":"e_1_2_13_27_1","doi-asserted-by":"publisher","DOI":"10.1002\/cncr.30171"},{"key":"e_1_2_13_28_1","doi-asserted-by":"publisher","DOI":"10.1089\/jayao.2017.0006"},{"key":"e_1_2_13_29_1","doi-asserted-by":"publisher","DOI":"10.1002\/pon.5040"},{"key":"e_1_2_13_30_1","doi-asserted-by":"publisher","DOI":"10.1080\/08880018.2016.1204400"},{"key":"e_1_2_13_31_1","doi-asserted-by":"publisher","DOI":"10.1002\/pon.3225"},{"key":"e_1_2_13_32_1","doi-asserted-by":"publisher","DOI":"10.1188\/15.Cjon.81\u201088"},{"key":"e_1_2_13_33_1","doi-asserted-by":"publisher","DOI":"10.1080\/07347332.2018.1535531"},{"key":"e_1_2_13_34_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jad.2020.01.080"},{"key":"e_1_2_13_35_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpainsymman.2008.09.010"},{"key":"e_1_2_13_36_1","doi-asserted-by":"publisher","DOI":"10.1188\/10.Onf.160\u2010167"},{"key":"e_1_2_13_37_1","doi-asserted-by":"publisher","DOI":"10.1002\/pon.3249"},{"key":"e_1_2_13_38_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2011.01.049"},{"key":"e_1_2_13_39_1","doi-asserted-by":"publisher","DOI":"10.1200\/jco.2008.21.1458"},{"key":"e_1_2_13_40_1","doi-asserted-by":"publisher","DOI":"10.1089\/jayao.2012.0015"},{"key":"e_1_2_13_41_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbi.2013.01.006"},{"key":"e_1_2_13_42_1","doi-asserted-by":"publisher","DOI":"10.1097\/MPH.0b013e3181ff0e2e"},{"key":"e_1_2_13_43_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejca.2016.11.017"},{"key":"e_1_2_13_44_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamaoncol.2020.2054"},{"key":"e_1_2_13_45_1","doi-asserted-by":"publisher","DOI":"10.1111\/ecc.13322"},{"key":"e_1_2_13_46_1","doi-asserted-by":"publisher","DOI":"10.1002\/nur.22170"},{"key":"e_1_2_13_47_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2012.47.8867"},{"key":"e_1_2_13_48_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2019.37.31_suppl.143Miller"},{"key":"e_1_2_13_49_1","doi-asserted-by":"publisher","DOI":"10.1016\/S2215\u20100366(16)30283\u20108"},{"key":"e_1_2_13_50_1","doi-asserted-by":"publisher","DOI":"10.1002\/cncr.32853"},{"key":"e_1_2_13_51_1","doi-asserted-by":"publisher","DOI":"10.1177\/13674935211014748"},{"key":"e_1_2_13_52_1","doi-asserted-by":"publisher","DOI":"10.4103\/0973\u20101075.105686"},{"key":"e_1_2_13_53_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pec.2019.06.022"},{"key":"e_1_2_13_54_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11764\u2010014\u20100375\u20101"},{"key":"e_1_2_13_55_1","doi-asserted-by":"publisher","DOI":"10.1111\/ecc.12462"},{"key":"e_1_2_13_56_1","doi-asserted-by":"publisher","DOI":"10.1158\/1055\u20109965.Epi\u201011\u20100239"},{"key":"e_1_2_13_57_1","doi-asserted-by":"publisher","DOI":"10.1002\/cncr.25867"},{"issue":"4","key":"e_1_2_13_58_1","first-page":"227","article-title":"Cultural factors influencing the mental health of Asian Americans","volume":"176","author":"Kramer E. J.","year":"2002","journal-title":"The Western Journal of Medicine"},{"key":"e_1_2_13_59_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejca.2011.03.001"},{"key":"e_1_2_13_60_1","doi-asserted-by":"publisher","DOI":"10.1002\/cncr.29946"},{"key":"e_1_2_13_61_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00520\u2010019\u201004936\u20105"},{"key":"e_1_2_13_62_1","doi-asserted-by":"publisher","DOI":"10.1097\/NCC.0b013e31823fcb53"},{"key":"e_1_2_13_63_1","doi-asserted-by":"publisher","DOI":"10.1002\/pon.4699"},{"key":"e_1_2_13_64_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pain.2011.08.006"},{"key":"e_1_2_13_65_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpainsymman.2013.12.243"},{"key":"e_1_2_13_66_1","doi-asserted-by":"publisher","DOI":"10.1007\/s13187\u2010016\u20100997\u20102"},{"key":"e_1_2_13_67_1","doi-asserted-by":"publisher","DOI":"10.1002\/cncr.33563"},{"key":"e_1_2_13_68_1","doi-asserted-by":"publisher","DOI":"10.1200\/jco.2005.03.210"},{"key":"e_1_2_13_69_1","doi-asserted-by":"publisher","DOI":"10.2147\/COAYA.S49174"},{"key":"e_1_2_13_70_1","doi-asserted-by":"publisher","DOI":"10.1200\/jco.2009.23.4534"},{"key":"e_1_2_13_71_1","doi-asserted-by":"publisher","DOI":"10.3322\/caac.21637"},{"key":"e_1_2_13_72_1","doi-asserted-by":"publisher","DOI":"10.1097\/xeb.0000000000000054"},{"key":"e_1_2_13_73_1","volume-title":"Cancer Pain (PDQ\u00ae) \u2013 Patient Version","author":"National Cancer Institute (NCI)","year":"2021"},{"key":"e_1_2_13_74_1","volume-title":"(PDQ\u00ae). Late effects of treatment for childhood cancer","author":"National Cancer Institute (NCI)","year":"2021"},{"key":"e_1_2_13_75_1","volume-title":"Survivor","author":"National Cancer Institute","year":"2021"},{"key":"e_1_2_13_76_1","doi-asserted-by":"publisher","DOI":"10.1007\/978-3-319-32364-0_8"},{"key":"e_1_2_13_77_1","doi-asserted-by":"publisher","DOI":"10.1186\/2049\u20103258\u201072\u201039"},{"key":"e_1_2_13_78_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11764\u2010013\u20100336\u20100"},{"key":"e_1_2_13_79_1","doi-asserted-by":"publisher","DOI":"10.1093\/jncics\/pkaa008"},{"key":"e_1_2_13_80_1","doi-asserted-by":"publisher","DOI":"10.1093\/jjco\/hyu102"},{"key":"e_1_2_13_81_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.n71"},{"key":"e_1_2_13_82_1","doi-asserted-by":"publisher","DOI":"10.1080\/08880018.2017.1338805"},{"key":"e_1_2_13_83_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0217314"},{"key":"e_1_2_13_84_1","doi-asserted-by":"publisher","DOI":"10.3324\/haematol.2010.036129"},{"key":"e_1_2_13_85_1","doi-asserted-by":"publisher","DOI":"10.1200\/jco.2014.57.7528"},{"key":"e_1_2_13_86_1","doi-asserted-by":"publisher","DOI":"10.2147\/PROM.S51658"},{"key":"e_1_2_13_87_1","doi-asserted-by":"publisher","DOI":"10.1177\/0269216307085183"},{"key":"e_1_2_13_88_1","doi-asserted-by":"publisher","DOI":"10.1200\/jco.2009.22.8635"},{"key":"e_1_2_13_89_1","doi-asserted-by":"publisher","DOI":"10.1089\/jayao.2019.0029"},{"key":"e_1_2_13_90_1","doi-asserted-by":"publisher","DOI":"10.4045\/tidsskr.17.0040"},{"key":"e_1_2_13_91_1","doi-asserted-by":"publisher","DOI":"10.1188\/11.ONF.672\u2010680"},{"key":"e_1_2_13_92_1","doi-asserted-by":"publisher","DOI":"10.1002\/pbc.25394"},{"key":"e_1_2_13_93_1","doi-asserted-by":"publisher","DOI":"10.1002\/ijc.31138"},{"key":"e_1_2_13_94_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejca.2010.03.001"},{"key":"e_1_2_13_95_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00381\u2010015\u20102669\u20107"},{"key":"e_1_2_13_96_1","doi-asserted-by":"publisher","DOI":"10.1002\/cncr.26146"},{"key":"e_1_2_13_97_1","doi-asserted-by":"publisher","DOI":"10.1093\/annonc\/mdn384"},{"key":"e_1_2_13_98_1","doi-asserted-by":"publisher","DOI":"10.1089\/jayao.2017.0037"},{"key":"e_1_2_13_99_1","volume-title":"Stata statistical software: Release 16","author":"StataCorp.","year":"2019"},{"key":"e_1_2_13_100_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.d4002"},{"key":"e_1_2_13_101_1","doi-asserted-by":"publisher","DOI":"10.1002\/cncr.27445"},{"key":"e_1_2_13_102_1","doi-asserted-by":"publisher","DOI":"10.1002\/cncr.32173"},{"key":"e_1_2_13_103_1","doi-asserted-by":"publisher","DOI":"10.1093\/annonc\/mdm05"},{"key":"e_1_2_13_104_1","volume-title":"Manual of epidemiology for district health management","author":"Vaughan J. P.","year":"1989"},{"key":"e_1_2_13_105_1","doi-asserted-by":"publisher","DOI":"10.1002\/pon.4439"},{"key":"e_1_2_13_106_1","doi-asserted-by":"publisher","DOI":"10.1037\/a0016779"},{"key":"e_1_2_13_107_1","doi-asserted-by":"publisher","DOI":"10.1002\/pon.1024"},{"key":"e_1_2_13_108_1","doi-asserted-by":"publisher","DOI":"10.1002\/cncr.32678"},{"key":"e_1_2_13_109_1","doi-asserted-by":"publisher","DOI":"10.1002\/da.20653"},{"key":"e_1_2_13_110_1","doi-asserted-by":"publisher","DOI":"10.1002\/pon.1641"},{"key":"e_1_2_13_111_1","doi-asserted-by":"publisher","DOI":"10.1542\/peds.110.1.42"},{"key":"e_1_2_13_112_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.psym.2013.12.005"},{"key":"e_1_2_13_113_1","doi-asserted-by":"publisher","DOI":"10.1200\/jco.2008.21.1433"},{"key":"e_1_2_13_114_1","doi-asserted-by":"publisher","DOI":"10.1093\/jpepsy\/jsv071"}],"container-title":["Journal of Clinical Nursing"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/jocn.16201","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/jocn.16201","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/jocn.16201","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,8,22]],"date-time":"2023-08-22T11:24:24Z","timestamp":1692703464000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/jocn.16201"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,1,10]]},"references-count":113,"journal-issue":{"issue":"9-10","published-print":{"date-parts":[[2023,5]]}},"alternative-id":["10.1111\/jocn.16201"],"URL":"https:\/\/doi.org\/10.1111\/jocn.16201","archive":["Portico"],"relation":{},"ISSN":["0962-1067","1365-2702"],"issn-type":[{"value":"0962-1067","type":"print"},{"value":"1365-2702","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,1,10]]},"assertion":[{"value":"2021-09-11","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2021-12-20","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2022-01-10","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}