{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,9]],"date-time":"2026-10-09T10:15:48Z","timestamp":1791540948463,"version":"4.3.4"},"reference-count":50,"publisher":"Wiley","issue":"1-2","license":[{"start":{"date-parts":[[2022,1,23]],"date-time":"2022-01-23T00:00:00Z","timestamp":1642896000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Journal of Clinical Nursing"],"published-print":{"date-parts":[[2023,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Aims and objectives<\/jats:title><jats:p>To identify the prevalence and determinants of medication administration errors (MAEs).<\/jats:p><\/jats:sec><jats:sec><jats:title>Background<\/jats:title><jats:p>Insight into determinants of MAEs is necessary to identify interventions to prevent MAEs.<\/jats:p><\/jats:sec><jats:sec><jats:title>Design<\/jats:title><jats:p>A prospective observational study in two Dutch hospitals, a university and teaching hospital.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Data were collected by observation. The primary outcome was the proportion of administrations with one or more MAEs. Secondary outcomes were the type, severity and determinants of MAEs. Multivariable mixed\u2010effects logistic regression analyses were used for determinant analysis. Reporting adheres to the STROBE guideline.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>MAEs occurred in 352 of 2576\u00a0medication administrations (13.7%). Of all MAEs (<jats:italic>n<\/jats:italic>\u00a0=\u00a0380), the most prevalent types were omission (<jats:italic>n<\/jats:italic>\u00a0=\u00a087) and wrong medication handling (<jats:italic>n<\/jats:italic>\u00a0=\u00a075). Forty\u2010five MAEs (11.8%) were potentially harmful. The pharmaceutical forms oral liquid (odds ratio [OR] 3.22, 95% confidence interval [CI] 1.43\u20137.25), infusion (OR 1.73, CI 1.02\u20132.94), injection (OR 3.52, CI 2.00\u20136.21), ointment (OR 10.78, CI 2.10\u201355.26), suppository\/enema (OR 6.39, CI 1.13\u201336.03) and miscellaneous (OR 6.17, CI 1.90\u201320.04) were more prone to MAEs compared to oral solid. MAEs were more likely to occur when medication was administered between 10\u00a0a.m.\u20132\u00a0p.m. (OR 1.91, CI 1.06\u20133.46) and 6\u00a0p.m.\u20137\u00a0a.m. (OR 1.88, CI 1.00\u20133.52) compared to 7\u00a0a.m.\u201310\u00a0a.m. and when administered by staff with higher professional education compared to staff with secondary vocational education (OR 1.68, CI 1.03\u20132.74). MAEs were less likely to occur in the teaching hospital (OR 0.17, CI 0.08\u20130.33). Day of the week, patient\u2010to\u2010nurse ratio, interruptions and other nurse characteristics (degree, experience, employment type) were not associated with MAEs.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>This study identified a high MAE prevalence. Identified determinants suggest that focusing interventions on complex pharmaceutical forms and error\u2010prone administration times may contribute to MAE reduction.<\/jats:p><\/jats:sec><jats:sec><jats:title>Relevance to clinical practice<\/jats:title><jats:p>The findings of this study can be used to develop targeted interventions to improve patient safety.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jocn.16215","type":"journal-article","created":{"date-parts":[[2022,1,24]],"date-time":"2022-01-24T05:43:03Z","timestamp":1643002983000},"page":"208-220","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":37,"title":["Prevalence and determinants of medication administration errors in clinical wards: A two\u2010centre prospective observational study"],"prefix":"10.1111","volume":"32","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1393-174X","authenticated-orcid":false,"given":"Janique Gabri\u00eblle","family":"Jessurun","sequence":"first","affiliation":[{"name":"Department of Hospital Pharmacy Erasmus MC, University Medical Center Rotterdam  Rotterdam The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6856-7028","authenticated-orcid":false,"given":"Nicole Geertruida Maria","family":"Hunfeld","sequence":"additional","affiliation":[{"name":"Department of Hospital Pharmacy Erasmus MC, University Medical Center Rotterdam  Rotterdam The Netherlands"},{"name":"Department of Intensive Care Erasmus MC, University Medical Center Rotterdam  Rotterdam The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michelle","family":"de Roo","sequence":"additional","affiliation":[{"name":"Department of Clinical Pharmacy Amphia Hospital  Breda The 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