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Unfortunately, even though pain is a relevant symptom in cancer and palliative care, little is currently known about topical treatments' availability and impact on pain management.<\/jats:p><\/jats:sec><jats:sec><jats:title>Design<\/jats:title><jats:p>A scoping review following JBI\u00ae methodology<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Searches were performed in CINAHL, LILACS, Embase, Web of Science, PubMed, Cochrane, NICE, Scopus, JBISRIR and grey literature, in English, Portuguese and Spanish, with no time limit. Two authors independently reviewed all citations and a third was called in case of divergence, and studies in adults with malignant fungal wounds reporting topical pain interventions were included. In addition, a data extraction tool for synthesis and thematic analysis was developed. This study followed the PRISMA\u2010ScR Checklist.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Seventy publications were selected from 796 records retrieved from databases. The studies mainly included non\u2010systematic reviews and case studies with only six clinical trials. According to the narrative synthesis, twenty therapies were identified, including the use of wound dressings (58.6%), analgesic drugs (55.7%), topical antimicrobials (25.7%), skin barriers (15.7%), cryotherapy (5.7%) and negative pressure wound therapy (4.3%). Therapies were recommended to be applied to the wound bed or the periwound skin. In 68.5% of the studies, a standardised assessment for pain was not described.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Topical therapies applied to malignant fungating wounds or periwound areas had been examined for pain management. However, their effectiveness was analysed in a few interventional studies, indicating the need for further primary studies to inform evidence\u2010based practice.<\/jats:p><\/jats:sec><jats:sec><jats:title>Implication for practice<\/jats:title><jats:p>Highlighted topical therapies for clinical practice consideration are opioids, anaesthetics and antimicrobials, with positive results described in randomised clinical trials.<\/jats:p><jats:p>This study did not include patients.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jocn.16508","type":"journal-article","created":{"date-parts":[[2022,9,3]],"date-time":"2022-09-03T02:42:27Z","timestamp":1662172947000},"page":"3015-3029","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["Topical therapy for pain management in malignant fungating wounds: A scoping review"],"prefix":"10.1111","volume":"32","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8308-2053","authenticated-orcid":false,"given":"Suzana Aparecida","family":"da Costa Ferreira","sequence":"first","affiliation":[{"name":"Health Consulting and Education HFSaude  Sao Paulo Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9850-3030","authenticated-orcid":false,"given":"Carol Viviana","family":"Serna Gonz\u00e1lez","sequence":"additional","affiliation":[{"name":"School of Nursing\u2010EEUSP, University of S\u00e3o Paulo \u2010 Adult Health Nursing Graduate Program\u2010PROESA  Sao Paulo Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3240-2226","authenticated-orcid":false,"given":"Magali","family":"Thum","sequence":"additional","affiliation":[{"name":"School of Nursing\u2010EEUSP, University of S\u00e3o Paulo \u2010 Adult Health Nursing Graduate Program\u2010PROESA  Sao Paulo Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5663-2195","authenticated-orcid":false,"given":"Adriane Aparecida","family":"da Costa Faresin","sequence":"additional","affiliation":[{"name":"S\u00e3o Paulo State Cancer Institute\u2010ICESP, Hospital das Cl\u00ednicas, Faculty of Medicine, University of Sao Paulo\u2010HCFMUSP  Sao Paulo Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8676-5757","authenticated-orcid":false,"given":"Kevin","family":"Woo","sequence":"additional","affiliation":[{"name":"Faculty of Health Sciences School of Nursing, Queen's University  Kingston Ontario Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1288-5761","authenticated-orcid":false,"given":"Vera L\u00facia Concei\u00e7\u00e3o","family":"de Gouveia Santos","sequence":"additional","affiliation":[{"name":"Medical\u2010Surgical Nursing Department Research Group of Enterostomal Therapy Nursing Stomatherapy\u2010GPET, Sao Paulo University of S\u00e3o Paulo, School of Nursing\u2010EEUSP  Sao Paulo Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2022,9,2]]},"reference":[{"key":"e_1_2_13_2_1","doi-asserted-by":"publisher","DOI":"10.1002\/14651858.CD003948.pub3"},{"key":"e_1_2_13_3_1","doi-asserted-by":"publisher","DOI":"10.17140\/PMHCOJ\u2010SE\u20101\u2010108"},{"key":"e_1_2_13_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/iwj.12665"},{"key":"e_1_2_13_5_1","doi-asserted-by":"publisher","DOI":"10.3390\/cancers11040510"},{"key":"e_1_2_13_6_1","doi-asserted-by":"publisher","DOI":"10.5114\/aoms.2018.72566"},{"key":"e_1_2_13_7_1","unstructured":"daCosta Ferreira S. 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