{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,24]],"date-time":"2026-09-24T18:02:36Z","timestamp":1790272956079,"version":"4.1.0"},"reference-count":51,"publisher":"Wiley","issue":"13-14","license":[{"start":{"date-parts":[[2022,9,8]],"date-time":"2022-09-08T00:00:00Z","timestamp":1662595200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82071900"],"award-info":[{"award-number":["82071900"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Journal of Clinical Nursing"],"published-print":{"date-parts":[[2023,7]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Aims and objectives<\/jats:title><jats:p>To investigate, for the first time, aberrant time\u2010varying local brain activity in nurses following night shift\u2013related sleep deprivation (SD) and its association with memory decline.<\/jats:p><\/jats:sec><jats:sec><jats:title>Background<\/jats:title><jats:p>Prior studies have elucidated alterations in static local brain activity resulting from SD in the occupations outside medical profession.<\/jats:p><\/jats:sec><jats:sec><jats:title>Design<\/jats:title><jats:p>A longitudinal study followed the STROBE recommendations.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Twenty female nurses underwent resting\u2010state functional magnetic resonance imaging and memory function assessment (by Complex Figure Test (CFT) and the California Verbal Learning Test, Second Edition (CVLT\u2010II)) twice, once in a rested wakefulness (RW) state and another after SD. By combining the sliding\u2010window approach and amplitude of low\u2010frequency fluctuation (ALFF) analysis, the dynamic ALFF (dALFF) variability was calculated to reflect the characteristics of dynamic local brain activity.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Poor performance on the CFT and CVLT\u2010II was observed in nurses with night shift\u2013related SD. Reduced dALFF variability was found in a set of cognition\u2010related brain regions (including the medial\/middle\/superior frontal gyrus, anterior\/posterior cingulate gyrus, precuneus, angular gyrus, orbitofrontal and subgenual areas, and posterior cerebellum lobe), while increased dALFF variability was observed in the somatosensory\u2010related, visual and auditory regions. SD\u2010related dALFF variability alterations correlated with changes in subjects' performance on the CFT and CVLT\u2010II.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Night shift\u2013related SD disturbed dynamic brain activity in high cognitive regions and induced compensatory reactions in primary perceptual cortex. Identifying dALFF variability abnormalities may broaden our understanding of neural substrates underlying SD\u2010related cognitive alterations, especially memory dysfunction.<\/jats:p><\/jats:sec><jats:sec><jats:title>Relevance to clinical practice<\/jats:title><jats:p>Night shift\u2013related SD is as an important occupational hazard affecting brain function in nurses. The effective countermeasure addressing the adverse outcomes of SD should be advocated for nurses.<\/jats:p><\/jats:sec><jats:sec><jats:title>Patient or public contribution<\/jats:title><jats:p>Patients or public were not involved in the design and implementation of the study or the analysis and interpretation of the data.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jocn.16515","type":"journal-article","created":{"date-parts":[[2022,9,9]],"date-time":"2022-09-09T05:11:57Z","timestamp":1662700317000},"page":"3852-3862","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":16,"title":["Altered dynamic brain activity and its association with memory decline after night shift\u2010related sleep deprivation in nurses"],"prefix":"10.1111","volume":"32","author":[{"given":"Fei\u2010Xin","family":"Yan","sequence":"first","affiliation":[{"name":"Department of Nursing Fujian Medical University Union Hospital  Fuzhou China"},{"name":"Department of Cardiovascular Surgery Fujian Medical University Union Hospital  Fuzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jian\u2010Ling","family":"Lin","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular Surgery Fujian Medical University Union Hospital  Fuzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jia\u2010Hui","family":"Lin","sequence":"additional","affiliation":[{"name":"Department of Radiology Fujian Medical University Union Hospital  Fuzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7568-8709","authenticated-orcid":false,"given":"Hua\u2010Jun","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Radiology Fujian Medical University Union Hospital  Fuzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yan\u2010Juan","family":"Lin","sequence":"additional","affiliation":[{"name":"Department of Nursing Fujian Medical University Union Hospital  Fuzhou China"},{"name":"Department of Cardiovascular Surgery Fujian Medical University Union Hospital  Fuzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2022,9,8]]},"reference":[{"key":"e_1_2_14_2_1","doi-asserted-by":"publisher","DOI":"10.1093\/cercor\/bhs352"},{"key":"e_1_2_14_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/jsr.12371"},{"key":"e_1_2_14_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/jsr.13329"},{"key":"e_1_2_14_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuron.2014.10.015"},{"key":"e_1_2_14_6_1","doi-asserted-by":"publisher","DOI":"10.1002\/jmri.27521"},{"key":"e_1_2_14_7_1","doi-asserted-by":"publisher","DOI":"10.3389\/fnins.2018.00994"},{"key":"e_1_2_14_8_1","doi-asserted-by":"publisher","DOI":"10.3389\/fneur.2018.00588"},{"key":"e_1_2_14_9_1","doi-asserted-by":"publisher","DOI":"10.1002\/hbm.24902"},{"key":"e_1_2_14_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.sleep.2011.09.019"},{"key":"e_1_2_14_11_1","doi-asserted-by":"publisher","DOI":"10.2147\/NDT.S78335"},{"key":"e_1_2_14_12_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598\u2010021\u201084417\u20100"},{"key":"e_1_2_14_13_1","volume-title":"California verbal learning test\u2010second edition","author":"Delis D. 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