{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,28]],"date-time":"2025-11-28T17:28:01Z","timestamp":1764350881304,"version":"3.40.5"},"reference-count":34,"publisher":"Wiley","issue":"21-22","license":[{"start":{"date-parts":[[2023,8,16]],"date-time":"2023-08-16T00:00:00Z","timestamp":1692144000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001168","name":"Cancer Council Queensland","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001168","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Journal of Clinical Nursing"],"published-print":{"date-parts":[[2023,11]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Aim<\/jats:title><jats:p>To test the feasibility of a study protocol that compared the efficacy of neutral\u2010 and negative\u2010pressure needleless connectors (NCs).<\/jats:p><\/jats:sec><jats:sec><jats:title>Design<\/jats:title><jats:p>A single\u2010centre, parallel\u2010group, pilot randomised control trial.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Our study compared neutral\u2010(intervention) and negative\u2010pressure (control) NCs among adult patients in an Australian hospital. The primary feasibility outcome was measured against predetermined criteria (e.g. eligibility, attrition). The primary efficacy outcome was all\u2010cause peripheral intravenous catheter failure, analysed as time\u2010to\u2010event data.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>In total, 201 (100 control; 101 intervention) participants were enrolled between March 2020 and September 2020. All feasibility criteria were met except eligibility, which was lower (78%) than the 90% criterion. All\u2010cause peripheral intravenous catheter failure was significantly higher in the intervention group (39%) compared to control (19%).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>With minor modifications to participant screening for eligibility, this randomised control trial is feasible for a large multicentre randomised control trial. The neutral NC was associated with an increased risk of peripheral intravenous catheter failure.<\/jats:p><\/jats:sec><jats:sec><jats:title>Implications for the Profession and\/or Patient Care<\/jats:title><jats:p>There are several NC designs available, often identified by their mechanism of pressure (positive, negative and neutral). However, NCs can contribute to peripheral intravenous catheter failure. This is the first randomised controlled trial to compare neutral and negative NC designs. Negative pressure NCs had lower PIVC failure compared to neutral NCs, however the results might not be generalisable to other brands or treatment settings. Further high\u2010quality research is needed to explore NC design.<\/jats:p><\/jats:sec><jats:sec><jats:title>Reporting Method<\/jats:title><jats:p>Study methods and results reported in adherence to the CONSORT Statement.<\/jats:p><\/jats:sec><jats:sec><jats:title>Patient or Public Contribution<\/jats:title><jats:p>No patient or public contribution.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jocn.16852","type":"journal-article","created":{"date-parts":[[2023,8,20]],"date-time":"2023-08-20T21:52:46Z","timestamp":1692568366000},"page":"7909-7919","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Controlling peripheral intravenous catheter failure by needleless connector design: A pilot randomised controlled\u00a0trial"],"prefix":"10.1111","volume":"32","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5779-1304","authenticated-orcid":false,"given":"Nicole","family":"Marsh","sequence":"first","affiliation":[{"name":"Nursing and Midwifery Research Centre Internal Medicine Services Workforce Development and Education Unit Royal Brisbane and Women's Hospital  Herston Queensland Australia"},{"name":"School of Nursing and Midwifery Alliance for Vascular Access Teaching and Research (AVATAR) School of Pharmacy and Medical Science School of Medicine and Dentistry Griffith University  Nathan Queensland Australia"},{"name":"School of Nursing, Midwifery and Social Work, School of Medicine and Dentistry The University of Queensland  St Lucia Queensland Australia"},{"name":"Patient\u2010Centred Health Services, Menzies Health Institute Queensland Griffith University  Gold Coast Queensland Australia"},{"name":"School of Nursing Queensland University of Technology  Kelvin Grove 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