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Synthesis highlights a complex interplay between self\u2010reported perception and the observed experience of potential occupational exposure to cytotoxic drugs.<\/jats:p><\/jats:sec><jats:sec><jats:title>Implications for Professional Practice<\/jats:title><jats:p>The framework synthesis highlights the difference between the perception of espoused practice and the experience of practice. Observation and risk assessment must be used to enhance safe practice. Organisations must take seriously the perception and experience of the adverse effects of administering cytotoxic drugs to support cancer nurses.<\/jats:p><\/jats:sec><jats:sec><jats:title>Reporting Method<\/jats:title><jats:p>Joanna Briggs Institute's (JBI) methodology for systematic reviews and framework synthesis indexed studies deductively and inductively.<\/jats:p><jats:p>No patient or public contribution.<\/jats:p><\/jats:sec><jats:sec><jats:title>Trial Registration<\/jats:title><jats:p><jats:ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" xlink:href=\"https:\/\/www.crd.york.ac.uk\/prospero\/\">PROSPERO<\/jats:ext-link>: CRD42022289276<\/jats:p><\/jats:sec>","DOI":"10.1111\/jocn.17488","type":"journal-article","created":{"date-parts":[[2024,10,29]],"date-time":"2024-10-29T07:07:16Z","timestamp":1730185636000},"page":"4585-4601","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":16,"title":["Global Cancer Nurse's 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