{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,9]],"date-time":"2026-05-09T07:11:11Z","timestamp":1778310671831,"version":"3.51.4"},"reference-count":49,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2026,2,4]],"date-time":"2026-02-04T00:00:00Z","timestamp":1770163200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,2,4]],"date-time":"2026-02-04T00:00:00Z","timestamp":1770163200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Journal of Clinical Nursing"],"published-print":{"date-parts":[[2026,6]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Aims<\/jats:title>\n                    <jats:p>To identify symptom clusters in haematological malignancy patients during chemotherapy and determine the factors associated with different symptom clusters.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Design<\/jats:title>\n                    <jats:p>A cross\u2010sectional study.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Method<\/jats:title>\n                    <jats:p>Convenience sampling was used to investigate haematological malignancy patients hospitalised for chemotherapy at a tertiary teaching hospital in Chengdu, China, from January 2021 to December 2023. Participants completed the Chinese version of the Condensed Memorial Symptom Assessment Scale. Hierarchical cluster analysis was used to identify symptom clusters; univariate analyses and logistic regression analyses were used to determine their related factors. This study was reported following the STROBE checklist.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>A total of 600 participants were included in the study. We have identified the psychological, sleep, pain\u2010fatigue, gastrointestinal\u2010asthenia symptom clusters in haematological malignancy patients during chemotherapy. Binary logistic regression analysis indicated that being female and having lactate dehydrogenase levels of 220\u2009IU\/L or higher are associated with an increased risk for the psychological symptom cluster. The sleep symptom cluster is more likely to occur in females, those with a prognostic nutritional index &lt;\u200945, lactate dehydrogenase \u2265\u2009220\u2009IU\/L and platelet\u2010to\u2010lymphocyte ratio \u2265\u2009107.85. Female, the prognostic nutritional index &lt;\u200945 and age \u2265\u200960\u2009years are correlated with the pain\u2010fatigue symptom cluster. The gastrointestinal\u2010asthenia symptom cluster is related to female, a diagnosis of acute leukaemia or lymphoma, lactate dehydrogenase \u2265\u2009220\u2009IU\/L and prognostic nutritional index &lt;\u200945.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Adult haematological malignancy patients undergoing chemotherapy experience multiple symptoms that can be further divided into four symptom clusters. The occurrence of symptom clusters is influenced by a combination of patient sociodemographic characteristics, disease conditions and biochemical indicators.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Relevance to Clinical Practice<\/jats:title>\n                    <jats:p>The symptom burden is a major issue for haematological malignancy patients during chemotherapy. Health caregivers should focus on the connection between symptoms rather than individual symptoms when developing and providing interventions. Identifying the factors influencing symptom clusters in haematological malignancy patients should be the basis for accurate, efficient and cost\u2010effective interventions.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Patient or Public Contribution<\/jats:title>\n                    <jats:p>The patients completed the questionnaires during the data collection in this study.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/jocn.70230","type":"journal-article","created":{"date-parts":[[2026,2,4]],"date-time":"2026-02-04T15:11:16Z","timestamp":1770217876000},"page":"2706-2718","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Symptom Clusters and Influencing Factors in Adult Patients With Haematological Malignancies During Chemotherapy: A Cross\u2010Sectional Study"],"prefix":"10.1111","volume":"35","author":[{"given":"Yuqin","family":"Luo","sequence":"first","affiliation":[{"name":"Department of Hematology West China Hospital, Sichuan University  Chengdu Sichuan China"},{"name":"West China School of Nursing Sichuan University  Chengdu Sichuan China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xinwen","family":"Du","sequence":"additional","affiliation":[{"name":"Department of Hematology West China Hospital, Sichuan University  Chengdu Sichuan China"},{"name":"West China School of Nursing Sichuan University  Chengdu Sichuan China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Meijia","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Hematology West China Hospital, Sichuan University  Chengdu Sichuan China"},{"name":"West China School of Nursing Sichuan University  Chengdu Sichuan China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mei","family":"Yang","sequence":"additional","affiliation":[{"name":"Department of Hematology West China Hospital, Sichuan University  Chengdu Sichuan China"},{"name":"West China School of Nursing Sichuan University  Chengdu Sichuan China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jiawei","family":"Luo","sequence":"additional","affiliation":[{"name":"Biomedical Big Data Center, West China Hospital Sichuan University  Chengdu Sichuan China"},{"name":"West China School of Medicine Sichuan University  Chengdu Sichuan China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4468-9749","authenticated-orcid":false,"given":"Fengjiao","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Hematology West China Hospital, Sichuan University  Chengdu Sichuan China"},{"name":"West China School of Nursing Sichuan University  Chengdu Sichuan China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2026,2,4]]},"reference":[{"key":"e_1_2_13_2_1","doi-asserted-by":"publisher","DOI":"10.2147\/IJGM.S439149"},{"key":"e_1_2_13_3_1","doi-asserted-by":"publisher","DOI":"10.2147\/IJGM.S458922"},{"key":"e_1_2_13_4_1","doi-asserted-by":"publisher","DOI":"10.6004\/jnccn.2017.0117"},{"key":"e_1_2_13_5_1","doi-asserted-by":"publisher","DOI":"10.3390\/curroncol32020062"},{"key":"e_1_2_13_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/bjh.19326"},{"key":"e_1_2_13_7_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00520-022-06896-9"},{"key":"e_1_2_13_8_1","doi-asserted-by":"publisher","DOI":"10.1097\/NCC.0000000000000816"},{"key":"e_1_2_13_9_1","first-page":"465","article-title":"Symptom Clusters and Their Effect on the Functional Status of Patients With Cancer","volume":"28","author":"Dodd M. 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