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Accumulating evidence on non\u2010pharmacological interventions for lung cancer cough necessitates systematic evaluation to assess their efficacy.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Aim<\/jats:title>\n                    <jats:p>To synthesise evidence on non\u2010pharmacological interventions for managing cough in lung cancer patients.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Design<\/jats:title>\n                    <jats:p>A systematic review and meta\u2010analysis following the Preferred Reporting Items for Systematic reviews and Meta\u2010Analyses reporting guideline.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Nine databases were searched from inception to December 2024 to identify randomised controlled trials. Study quality was appraised using the Revised Cochrane Risk\u2010of\u2010Bias Tool for Randomised Trials. Meta\u2010analyses were performed for quantitative synthesis, with sources of heterogeneity examined using meta\u2010regression and subgroup analyses.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Thirty\u2010eight studies representing 2995 lung cancer patients were identified. These studies investigated acupuncture therapy, moxibustion, pulmonary rehabilitation, self\u2010management intervention, physical exercises, psychoeducation support, mindfulness, and multicomponent interventions. Non\u2010pharmacological interventions showed positive effects on cough severity and cough\u2010related quality of life. Additional benefits were observed for expectoration, dyspnea, and general quality of life. Pulmonary rehabilitation showed a greater effect on cough severity than other non\u2010pharmacological interventions.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Non\u2010pharmacological interventions are promising in improving cough, expectoration, dyspnea, and general quality of life among lung cancer patients. Pulmonary rehabilitation showed the most promising effect. Future research should adopt objective cough measures in addition to self\u2010reported measures.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Implications for the Profession and\/or Patient Care<\/jats:title>\n                    <jats:p>Non\u2010pharmacological interventions demonstrated potential effects in relieving cough and additional benefits in improving expectoration, dyspnea, and general quality of life among lung cancer patients. Healthcare professionals may adopt pulmonary rehabilitation for cough and related symptoms in lung cancer patients.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Impact<\/jats:title>\n                    <jats:p>As the first meta\u2010analysis addressing non\u2010pharmacological interventions for lung cancer cough, this study provides evidence supporting their clinical efficacy for improving cough and associated symptoms among patients with lung cancer.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Patient or Public Contribution<\/jats:title>\n                    <jats:p>No patient or Public contribution.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Registration<\/jats:title>\n                    <jats:p>PROSPERO CRD42024588729.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/jocn.70289","type":"journal-article","created":{"date-parts":[[2026,3,16]],"date-time":"2026-03-16T05:31:41Z","timestamp":1773639101000},"page":"3335-3356","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Non\u2010Pharmacological Interventions for Cough in Patients With Lung Cancer: A Systematic Review and Meta\u2010Analysis"],"prefix":"10.1111","volume":"35","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2938-8788","authenticated-orcid":false,"given":"Mengyao","family":"Cao","sequence":"first","affiliation":[{"name":"Li Ka Shing Faculty of Medicine, School of Nursing University of Hong Kong  Hong Kong China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7510-7545","authenticated-orcid":false,"given":"Xueyan","family":"Cheng","sequence":"additional","affiliation":[{"name":"Li Ka Shing Faculty of Medicine, School of Nursing University of Hong Kong  Hong Kong China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Victor Ho\u2010fun","family":"Lee","sequence":"additional","affiliation":[{"name":"Department of Clinical Oncology, Li Ka Shing Faculty of Medicine University of Hong Kong  Hong Kong China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9551-0991","authenticated-orcid":false,"given":"Chia\u2010Chin","family":"Lin","sequence":"additional","affiliation":[{"name":"Li Ka Shing Faculty of Medicine, School of Nursing University of Hong Kong  Hong Kong China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Denise Shuk Ting","family":"Cheung","sequence":"additional","affiliation":[{"name":"Li Ka Shing Faculty of Medicine, School of Nursing University of Hong Kong  Hong Kong China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,3,15]]},"reference":[{"key":"e_1_2_12_2_1","doi-asserted-by":"publisher","DOI":"10.1108\/jica\u201007\u20102025\u20100056"},{"key":"e_1_2_12_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/s2213\u20102600(17)30310\u20107"},{"key":"e_1_2_12_4_1","unstructured":"Cen Y.2022. \u201cClinical Exploratory Study of Percutaneous Acupoint Electrical Stimulation Combined With Intradermal Acupuncture in the Prevention and Treatment of Radiotherapy Pneumonia in Lung Cancer Patients.\u201d Master's thesis. 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