{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,17]],"date-time":"2026-04-17T18:00:15Z","timestamp":1776448815962,"version":"3.51.2"},"reference-count":38,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2018,6,10]],"date-time":"2018-06-10T00:00:00Z","timestamp":1528588800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"},{"start":{"date-parts":[[2018,6,10]],"date-time":"2018-06-10T00:00:00Z","timestamp":1528588800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Card Surg"],"published-print":{"date-parts":[[2018,7]]},"DOI":"10.1111\/jocs.13722","type":"journal-article","created":{"date-parts":[[2018,6,11]],"date-time":"2018-06-11T03:26:36Z","timestamp":1528687596000},"page":"374-384","source":"Crossref","is-referenced-by-count":13,"title":["Should the mitral valve be repaired for moderate ischemic mitral regurgitation at the time of revascularization surgery?"],"prefix":"10.1155","volume":"33","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4085-1294","authenticated-orcid":false,"given":"Mohammad Y.","family":"Salmasi","sequence":"first","affiliation":[{"name":"Department of Cardiothoracic Surgery; University Hospitals of Leicester; Leicester UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Amer","family":"Harky","sequence":"additional","affiliation":[{"name":"Department of Cardiac Surgery; St Bartholemew's Hospital; London UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mohammed F.","family":"Chowdhury","sequence":"additional","affiliation":[{"name":"Department of Cardiothoracic Surgery; University Hospitals of Leicester; Leicester UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ali","family":"Abdelnour","sequence":"additional","affiliation":[{"name":"Department of Cardiac Surgery; Royal Hospitals; Belfast UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anastasia","family":"Benjafield","sequence":"additional","affiliation":[{"name":"Department of Cardiac Surgery; Royal Brompton Hospital; London UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Farah","family":"Suker","sequence":"additional","affiliation":[{"name":"Department of Medical Sciences; University of Nottingham; Nottingham UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Stephanie","family":"Hubbard","sequence":"additional","affiliation":[{"name":"Department of Health Sciences; University of Leicester; Leicester UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hunaid A.","family":"Vohra","sequence":"additional","affiliation":[{"name":"Bristol Heart Institute; Bristol Royal Infirmary; Bristol UK"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2018,6,10]]},"reference":[{"key":"10.1111\/jocs.13722-BIB0001|jocs13722-cit-0001","first-page":"I51","article-title":"Current prognosis of ischemic mitral regurgitation. Implications for future management","volume":"78","author":"Hickey","year":"1988","journal-title":"Circulation"},{"key":"10.1111\/jocs.13722-BIB0002|jocs13722-cit-0002","doi-asserted-by":"crossref","first-page":"295","DOI":"10.1161\/01.CIR.0000151097.30779.04","article-title":"Heart failure and death after myocardial infarction in the community: the emerging role of mitral regurgitation","volume":"111","author":"Bursi","year":"2005","journal-title":"Circulation"},{"key":"10.1111\/jocs.13722-BIB0003|jocs13722-cit-0003","doi-asserted-by":"crossref","first-page":"1759","DOI":"10.1161\/01.CIR.103.13.1759","article-title":"Ischemic mitral regurgitation: long-term outcome and prognostic implications with quantitative Doppler assessment","volume":"103","author":"Grigioni","year":"2001","journal-title":"Circulation"},{"key":"10.1111\/jocs.13722-BIB0004|jocs13722-cit-0004","doi-asserted-by":"crossref","first-page":"971","DOI":"10.1016\/j.cjca.2014.06.022","article-title":"Basic mechanisms of mitral regurgitation","volume":"30","author":"Dal-Bianco","year":"2014","journal-title":"Can J Cardiol"},{"key":"10.1111\/jocs.13722-BIB0005|jocs13722-cit-0005","doi-asserted-by":"crossref","first-page":"1382","DOI":"10.1016\/S0140-6736(09)60692-9","article-title":"Mitral regurgitation","volume":"373","author":"Enriquez-Sarano","year":"2009","journal-title":"Lancet"},{"key":"10.1111\/jocs.13722-BIB0006|jocs13722-cit-0006","doi-asserted-by":"crossref","first-page":"1358","DOI":"10.1093\/eurheartj\/ehm001","article-title":"What are the characteristics of patients with severe, symptomatic, mitral regurgitation who are denied surgery","volume":"28","author":"Mirabel","year":"2007","journal-title":"Eur Heart J"},{"key":"10.1111\/jocs.13722-BIB0007|jocs13722-cit-0007","doi-asserted-by":"crossref","first-page":"2547","DOI":"10.1161\/CIRCULATIONAHA.113.005223","article-title":"Surgical revascularization is associated with maximal survival in patients with ischemic mitral regurgitation: a 20-year experience","volume":"129","author":"Castleberry","year":"2014","journal-title":"Circulation"},{"key":"10.1111\/jocs.13722-BIB0008|jocs13722-cit-0008","doi-asserted-by":"crossref","first-page":"1076","DOI":"10.1016\/j.jtcvs.2016.11.068","article-title":"2016 update to The American Association for Thoracic Surgery consensus guidelines: ischemic mitral valve regurgitation","volume":"153","author":"Kron","year":"2017","journal-title":"J Thorac Cardiovasc Surg"},{"key":"10.1111\/jocs.13722-BIB0009|jocs13722-cit-0009","doi-asserted-by":"crossref","first-page":"1476","DOI":"10.1016\/S0003-4975(02)03927-9","article-title":"Revascularization alone (without mitral valve repair) suffices in patients with advanced ischemic cardiomyopathy and mild-to-moderate mitral regurgitation","volume":"74","author":"Tolis","year":"2002","journal-title":"Ann Thorac Surg"},{"key":"10.1111\/jocs.13722-BIB0010|jocs13722-cit-0010","doi-asserted-by":"crossref","first-page":"e1","DOI":"10.1016\/j.jacc.2008.05.007","article-title":"2008 Focused update incorporated into the ACC\/AHA 2006 guidelines for the management of patients with valvular heart disease","volume":"52","author":"Bonow","year":"2008","journal-title":"J Am Coll Cardiol"},{"key":"10.1111\/jocs.13722-BIB0011|jocs13722-cit-0011","doi-asserted-by":"crossref","first-page":"777","DOI":"10.1016\/S0894-7317(03)00335-3","article-title":"Recommendations for evaluation of the severity of native valvular regurgitation with two-dimensional and Doppler echocardiography","volume":"16","author":"Zoghbi","year":"2003","journal-title":"J Am Soc Echocardiogr"},{"key":"10.1111\/jocs.13722-BIB0012|jocs13722-cit-0012","doi-asserted-by":"crossref","first-page":"177","DOI":"10.1016\/0197-2456(86)90046-2","article-title":"Meta-analysis in clinical trials","volume":"7","author":"DerSimonian","year":"1986","journal-title":"Control Clin Trials"},{"key":"10.1111\/jocs.13722-BIB0013|jocs13722-cit-0013","doi-asserted-by":"crossref","first-page":"2815","DOI":"10.1002\/(SICI)1097-0258(19981230)17:24<2815::AID-SIM110>3.0.CO;2-8","volume":"17","author":"Parmar","year":"1998","journal-title":"Stat Med"},{"key":"10.1111\/jocs.13722-BIB0014|jocs13722-cit-0014","unstructured":"Higgins JPT Green S Cochrane Handbook for Systematic Reviews of Interventions 2011 http:\/\/handbook-5-1.cochrane.org\/"},{"key":"10.1111\/jocs.13722-BIB0015|jocs13722-cit-0015","doi-asserted-by":"crossref","first-page":"d4002","DOI":"10.1136\/bmj.d4002","article-title":"Recommendations for examining and interpreting funnel plot asymmetry in meta-analyses of randomised controlled trials","volume":"343","author":"Sterne","year":"2011","journal-title":"BMJ"},{"key":"10.1111\/jocs.13722-BIB0016|jocs13722-cit-0016","doi-asserted-by":"crossref","first-page":"e1000100","DOI":"10.1371\/journal.pmed.1000100","article-title":"The PRISMA statement for reporting systematic reviews and meta-analyses of studies that evaluate health care interventions: explanation and elaboration","volume":"6","author":"Liberati","year":"2009","journal-title":"PLoS Med"},{"key":"10.1111\/jocs.13722-BIB0017|jocs13722-cit-0017","first-page":"416","article-title":"Coronary revascularization alone or with mitral valve repair: outcomes in patients with moderate ischemic mitral regurgitation","volume":"36","author":"Goland","year":"2009","journal-title":"Tex Heart Inst J"},{"key":"10.1111\/jocs.13722-BIB0018|jocs13722-cit-0018","doi-asserted-by":"crossref","first-page":"1468","DOI":"10.1016\/S0003-4975(02)03920-6","article-title":"Can late survival of patients with moderate ischemic mitral regurgitation be impacted by intervention on the valve","volume":"74","author":"Harris","year":"2002","journal-title":"Ann Thorac Surg"},{"key":"10.1111\/jocs.13722-BIB0019|jocs13722-cit-0019","doi-asserted-by":"crossref","first-page":"2502","DOI":"10.1161\/CIRCULATIONAHA.112.143818","article-title":"Coronary artery bypass surgery with or without mitral valve annuloplasty in moderate functional ischemic mitral regurgitation: final results of the Randomized Ischemic Mitral Evaluation (RIME) trial","volume":"126","author":"Chan","year":"2012","journal-title":"Circulation"},{"key":"10.1111\/jocs.13722-BIB0020|jocs13722-cit-0020","doi-asserted-by":"crossref","first-page":"473","DOI":"10.1111\/j.1540-8191.2001.tb00552.x","article-title":"Should mild-to-moderate and moderate ischemic mitral regurgitation be corrected in patients with impaired left ventricular function undergoing simultaneous coronary revascularization","volume":"16","author":"Prifti","year":"2001","journal-title":"J Card Surg"},{"key":"10.1111\/jocs.13722-BIB0021|jocs13722-cit-0021","first-page":"272","article-title":"Moderate ischemic mitral regurgitation and coronary artery bypass surgery: effect of mitral repair on clinical outcome","volume":"12","author":"Di Donato","year":"2003","journal-title":"J Heart Valve Dis"},{"key":"10.1111\/jocs.13722-BIB0022|jocs13722-cit-0022","doi-asserted-by":"crossref","first-page":"E201","DOI":"10.1532\/HSF98.2014337","article-title":"Surgical strategy for moderate ischemic mitral valve regurgitation: repair or ignore","volume":"17","author":"Diken","year":"2014","journal-title":"Heart Surg Forum"},{"key":"10.1111\/jocs.13722-BIB0023|jocs13722-cit-0023","doi-asserted-by":"crossref","first-page":"1187","DOI":"10.1016\/j.athoracsur.2010.03.103","article-title":"Impact of moderate ischemic mitral regurgitation after isolated coronary artery bypass grafting","volume":"90","author":"Fattouch","year":"2010","journal-title":"Ann Thorac Surg"},{"key":"10.1111\/jocs.13722-BIB0024|jocs13722-cit-0024","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1007\/s12055-016-0472-z","article-title":"Coronary artery bypass grafting versus concomitant mitral valve annuloplasty in moderate ischemic mitral regurgitation: 4-year follow-up","volume":"33","author":"Hamouda","year":"2017","journal-title":"Indian J Thorac Cardiovasc Surg"},{"key":"10.1111\/jocs.13722-BIB0025|jocs13722-cit-0025","doi-asserted-by":"crossref","first-page":"2178","DOI":"10.1056\/NEJMoa1410490","article-title":"Surgical treatment of moderate ischemic mitral regurgitation","volume":"371","author":"Smith","year":"2014","journal-title":"N Engl J Med"},{"key":"10.1111\/jocs.13722-BIB0026|jocs13722-cit-0026","doi-asserted-by":"crossref","first-page":"1471","DOI":"10.1016\/j.jtcvs.2013.05.024","article-title":"Effect of systematic downsizing rigid ring annuloplasty in patients with moderate ischemic mitral regurgitation","volume":"147","author":"Bouchard","year":"2014","journal-title":"J Thorac Cardiovasc Surg"},{"key":"10.1111\/jocs.13722-BIB0027|jocs13722-cit-0027","doi-asserted-by":"crossref","first-page":"570","DOI":"10.1016\/j.athoracsur.2005.03.034","article-title":"Long-term survival after surgical revascularization for moderate ischemic mitral regurgitation","volume":"80","author":"Wong","year":"2005","journal-title":"Ann Thorac Surg"},{"key":"10.1111\/jocs.13722-BIB0028|jocs13722-cit-0028","doi-asserted-by":"crossref","first-page":"2178","DOI":"10.1056\/NEJMoa1410490","article-title":"Surgical treatment of moderate ischemic mitral regurgitation","volume":"371","author":"Smith","year":"2014","journal-title":"N Engl J Med"},{"key":"10.1111\/jocs.13722-BIB0029|jocs13722-cit-0029","doi-asserted-by":"crossref","first-page":"68","DOI":"10.1161\/hc37t1.094706","article-title":"Does coronary artery bypass grafting alone correct moderate ischemic mitral regurgitation","volume":"104","author":"Aklog","year":"2001","journal-title":"Circulation"},{"key":"10.1111\/jocs.13722-BIB0030|jocs13722-cit-0030","first-page":"207","article-title":"Ischemic mitral regurgitation: mechanisms and echocardiographic classification","volume":"9","author":"Agricola","year":"2008","journal-title":"Eur J Echocardiogr"},{"key":"10.1111\/jocs.13722-BIB0031|jocs13722-cit-0031","doi-asserted-by":"crossref","first-page":"641","DOI":"10.1016\/S0735-1097(00)01134-7","article-title":"Mechanism of ischemic mitral regurgitation with segmental left ventricular dysfunction: three-dimensional echocardiographic studies in models of acute and chronic progressive regurgitation","volume":"37","author":"Otsuji","year":"2001","journal-title":"J Am Coll Cardiol"},{"key":"10.1111\/jocs.13722-BIB0032|jocs13722-cit-0032","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1111\/jocs.12662","article-title":"A meta-analysis of ring annuloplasty versus combined ring annuloplasty and subvalvular repair for moderate-to-severe functional mitral regurgitation","volume":"31","author":"Mihos","year":"2016","journal-title":"J Card Surg"},{"key":"10.1111\/jocs.13722-BIB0033|jocs13722-cit-0033","doi-asserted-by":"crossref","first-page":"1932","DOI":"10.1056\/NEJMoa1602003","article-title":"Two-year outcomes of surgical treatment of moderate ischemic mitral regurgitation","volume":"374","author":"Michler","year":"2016","journal-title":"N Engl J Med"},{"key":"10.1111\/jocs.13722-BIB0034|jocs13722-cit-0034","doi-asserted-by":"crossref","first-page":"109","DOI":"10.2459\/JCM.0b013e32831c84b0","article-title":"Does combined mitral valve surgery improve survival when compared to revascularization alone in patients with ischemic mitral regurgitation? A meta-analysis on 2479 patients","volume":"10","author":"Benedetto","year":"2009","journal-title":"J Cardiovasc Med (Hagerstown)"},{"key":"10.1111\/jocs.13722-BIB0035|jocs13722-cit-0035","doi-asserted-by":"crossref","first-page":"212","DOI":"10.1093\/ejcts\/ezw022","article-title":"Meta-analysis of concomitant mitral valve repair and coronary artery bypass surgery versus isolated coronary artery bypass surgery in patients with moderate ischaemic mitral regurgitation","volume":"50","author":"Kopjar","year":"2016","journal-title":"Eur J Cardio-thoracic Surg"},{"key":"10.1111\/jocs.13722-BIB0036|jocs13722-cit-0036","doi-asserted-by":"crossref","first-page":"127","DOI":"10.1016\/j.jtcvs.2017.03.039","article-title":"Mitral valve surgery and coronary artery bypass grafting for moderate-to-severe ischemic mitral regurgitation: meta-analysis of clinical and echocardiographic outcomes","volume":"154","author":"Virk","year":"2017","journal-title":"J Thorac Cardiovasc Surg"},{"key":"10.1111\/jocs.13722-BIB0037|jocs13722-cit-0037","doi-asserted-by":"crossref","first-page":"734","DOI":"10.1016\/j.amjcard.2016.11.024","article-title":"Meta-analysis of usefulness of concomitant mitral valve repair or replacement for moderate ischemic mitral regurgitation with coronary artery bypass grafting","volume":"119","author":"Altarabsheh","year":"2017","journal-title":"Am J Cardiol"},{"key":"10.1111\/jocs.13722-BIB0038|jocs13722-cit-0038","doi-asserted-by":"crossref","first-page":"1358","DOI":"10.1016\/j.athoracsur.2011.05.056","article-title":"Mitral valve replacement is a viable alternative to mitral valve repair for ischemic mitral regurgitation: a case-matched study","volume":"92","author":"Chan","year":"2011","journal-title":"Ann Thorac Surg"}],"container-title":["Journal of Cardiac Surgery"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fjocs.13722","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/onlinelibrary.wiley.com\/wol1\/doi\/10.1111\/jocs.13722\/fullpdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,1,6]],"date-time":"2023-01-06T11:51:08Z","timestamp":1673005868000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/jocs.13722"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,6,10]]},"references-count":38,"journal-issue":{"issue":"7","published-print":{"date-parts":[[2018,7]]}},"URL":"https:\/\/doi.org\/10.1111\/jocs.13722","archive":["Portico"],"relation":{},"ISSN":["0886-0440"],"issn-type":[{"value":"0886-0440","type":"print"}],"subject":[],"published":{"date-parts":[[2018,6,10]]}}}