{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,24]],"date-time":"2026-04-24T23:14:23Z","timestamp":1777072463385,"version":"3.51.4"},"reference-count":20,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2019,8,2]],"date-time":"2019-08-02T00:00:00Z","timestamp":1564704000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Journal of Cardiac Surgery"],"published-print":{"date-parts":[[2019,10]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Backgrounds<\/jats:title>\n                    <jats:p>Aortic valve and prosthetic valve endocarditis present a challenging subgroup of patients at high risk. We analyzed our experience using the Medtronic Freestyle in full root technique for the treatment of these cases over 18\u2010year time period.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      We investigated the endocarditis subgroup from our cohort of 971 patients and compared results against other valve types with propensity score matching implementing nearest neighbor method.\n                      <jats:italic>T<\/jats:italic>\n                      \u2010test,\n                      <jats:italic>\u03c7<\/jats:italic>\n                      <jats:sup>2<\/jats:sup>\n                      test, logistic regression, and Cox regression were performed.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Fifty\u2010four patients from the Freestyle group (FS) were matched against 54 patients from a cohort of 376 aortic valve\/root endocarditis patients treated by other valve types (non\u2010FS). Hospital mortality was 9\/54 (16.7%) in the FS vs 13\/54 (24.1%) in the non\u2010FS group (\n                      <jats:italic>P<\/jats:italic>\n                      \u2009=\u2009.33). Variables age (\n                      <jats:italic>P<\/jats:italic>\n                      \u2009=\u2009.003) and renal impairment (\n                      <jats:italic>P<\/jats:italic>\n                      \u2009=\u2009.026) had an impact on mortality according to Cox regression analysis for early results. Variables with significant risk for long\u2010term mortality included postoperative renal impairment (\n                      <jats:italic>P<\/jats:italic>\n                      \u2009=\u2009.0001) and multiorgan failure (\n                      <jats:italic>P<\/jats:italic>\n                      \u2009=\u2009.0001). Recurrent infection was low (1.8% for FS and 3.7% for non\u2010FS group), and freedom from reoperation was 97.2%. Use of the Medtronic Freestyle was no significant risk factor for long\u2010term mortality.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>The Freestyle stentless xenograft is a viable alternative for treatment of valve\/root and prosthetic endocarditis. In our experience, it showed good postoperative performance with low rate of reinfection while having an acceptable operative risk\u2010profile for this high\u2010risk cohort.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/jocs.14176","type":"journal-article","created":{"date-parts":[[2019,8,2]],"date-time":"2019-08-02T20:15:10Z","timestamp":1564776910000},"page":"957-964","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Use of the Medtronic Freestyle for aortic valve infection: A retrospective propensity score matched analysis"],"prefix":"10.1155","volume":"34","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9445-5716","authenticated-orcid":false,"given":"Jerry","family":"Easo","sequence":"first","affiliation":[{"name":"Department of Cardiac Surgery, European Medical School Oldenburg\u2010Groningen University Clinic Oldenburg  Oldenburg 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