{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,18]],"date-time":"2025-11-18T08:31:21Z","timestamp":1763454681186,"version":"3.45.0"},"reference-count":24,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2019,9,2]],"date-time":"2019-09-02T00:00:00Z","timestamp":1567382400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Journal of Cardiac Surgery"],"published-print":{"date-parts":[[2019,11]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Objectives<\/jats:title>\n                    <jats:p>To determine whether concomitant mitral stenosis (MS) impairs outcomes after transcatheter aortic valve implantation (TAVI) in patients with severe aortic stenosis (AS), we performed a meta\u2010analysis of currently available evidence.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>To identify all observational comparative studies of outcomes after TAVI for AS in patients with MS vs patients with no\u2010MS, we searched databases (MEDLINE and EMBASE) using web\u2010based search engines (PubMed and OVID). Studies meeting the following criteria were included; the design was an observational study; the study population was patients undergoing TAVI for AS; outcomes in patients with MS were compared with those in patients with no\u2010MS. Study\u2010specific estimates were then pooled using inverse variance\u2010weighted averages of logarithmic odds and hazard ratios in the random\u2010effects model.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      We identified six eligible studies including 111\u2009621 patients undergoing TAVI. In pooled analyses, postprocedural incidence of\u2009\u2265\u2009moderate paravalvular aortic regurgitation (PAR) (\n                      <jats:italic>P<\/jats:italic>\n                      \u2009=\u2009.02), early all\u2010cause mortality (\n                      <jats:italic>P<\/jats:italic>\n                      \u2009=\u2009.008), early incidence of myocardial infarction (MI) (\n                      <jats:italic>P<\/jats:italic>\n                      \u2009=\u2009.01), and midterm all\u2010cause mortality (\n                      <jats:italic>P<\/jats:italic>\n                      \u2009=\u2009.03) after TAVI were significantly higher in patients with MS than in patients with no\u2010MS. There were no significant differences in early incidence of stroke, major bleeding, acute kidney injury, and new permanent pacemaker implantation after TAVI between patients with MS and patients with no\u2010MS. When the study for mitral annular calcification was excluded in the pooled analyses, no results except for MI were substantially altered but the significance for early incidence of MI disappeared (\n                      <jats:italic>P<\/jats:italic>\n                      \u2009=\u2009.10).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Postprocedural incidence of\u2009\u2265\u2009moderate PAR, early all\u2010cause mortality, early incidence of MI, and midterm all\u2010cause mortality after TAVI are higher in patients with MS than in patients with no\u2010MS.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/jocs.14233","type":"journal-article","created":{"date-parts":[[2019,9,2]],"date-time":"2019-09-02T04:59:23Z","timestamp":1567400363000},"page":"1256-1263","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["A meta\u2010analysis of impact of mitral stenosis on outcomes after transcatheter aortic valve implantation"],"prefix":"10.1155","volume":"34","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5594-8072","authenticated-orcid":false,"given":"Hisato","family":"Takagi","sequence":"first","affiliation":[{"name":"Department of Cardiovascular Surgery Shizuoka Medical Center  Shizuoka Japan"},{"name":"Department of Cardiovascular Surgery Kitasato University School of Medicine  Sagamihara Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yosuke","family":"Hari","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular Surgery Shizuoka Medical Center  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