{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,30]],"date-time":"2026-03-30T21:10:14Z","timestamp":1774905014147,"version":"3.50.1"},"reference-count":18,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2022,2,11]],"date-time":"2022-02-11T00:00:00Z","timestamp":1644537600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Journal of Cardiac Surgery"],"published-print":{"date-parts":[[2022,5]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Over the course of time, new developments associated with the embryogenesis of the murine heart have served to clarify the developmental processes observed in the human heart. This evidence allows for the creation of a developmental framework for many congenital cardiac defects.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Aims<\/jats:title>\n                    <jats:p>We aim to solidify the framework related to the categorization of both solitary and multiple ventricular septal defects.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Materials and Methods<\/jats:title>\n                    <jats:p>Mice having genetic perturbation of the Furin enzyme have demonstrated perimembranous and juxta\u2010arterial ventricular septal defects, permitting the inference to be made that these defects can co\u2010exist with defects occurring within the apical muscular septum.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Basis of developmental evidence, furthermore, all interventricular communications can be placed into one of three groups, namely\u00a0those which are perimembranous, juxta\u2010arterial, and muscular. All of the defects are described based on their borders as seen from the morphologically right ventricle. Our focus here will be on those defects within the muscular ventricular septum, recognizing that such defects can co\u2010exist with those that are perimembranous. We discuss the differentiation of multiple discrete defects from those referred to as the \u201cSwiss cheese\u201d variant.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>As we show, appropriate surgical management requires an understanding of the specific terminology, as the surgical approach may differ depending on the combination of the individual defects. Data from the Society for Thoracic Surgeons revealed that both mortality and morbidity were increased in the setting of multiple as opposed to solitary ventricular septal defects.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/jocs.16242","type":"journal-article","created":{"date-parts":[[2022,2,11]],"date-time":"2022-02-11T04:21:28Z","timestamp":1644553288000},"page":"1353-1360","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["A reassessment of the anatomical features of multiple ventricular septal defects"],"prefix":"10.1155","volume":"37","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9885-3789","authenticated-orcid":false,"given":"Diane E.","family":"Spicer","sequence":"first","affiliation":[{"name":"Heart Institute Johns Hopkins All Children's Hospital St. Petersburg Florida USA"},{"name":"Department of Pediatric Cardiology University of Florida Gainesville Florida USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5163-9021","authenticated-orcid":false,"given":"Robert H.","family":"Anderson","sequence":"additional","affiliation":[{"name":"Institute of Biomedical Sciences Newcastle University Newcastle\u2010upon\u2010Tyne UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1672-1502","authenticated-orcid":false,"given":"Ujjwal K.","family":"Chowdhury","sequence":"additional","affiliation":[{"name":"Department of Cardiothoracic and Vascular Surgery All India Institute of Medical Sciences New Delhi India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9533-8853","authenticated-orcid":false,"given":"Lakshmi K.","family":"Sankhyan","sequence":"additional","affiliation":[{"name":"Department of Cardiothoracic Surgery All India Institute of Medical Sciences Bilaspur Himachal Pradesh India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0372-9951","authenticated-orcid":false,"given":"Niwin","family":"George","sequence":"additional","affiliation":[{"name":"Department of Cardiothoracic and Vascular Surgery All India Institute of Medical Sciences New Delhi India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6786-8304","authenticated-orcid":false,"given":"Niraj N.","family":"Pandey","sequence":"additional","affiliation":[{"name":"Department of Cardiac Radiology All India Institute of Medical Sciences New Delhi India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3267-1899","authenticated-orcid":false,"given":"Saurabh K.","family":"Gupta","sequence":"additional","affiliation":[{"name":"Department of Cardiology All India Institute of Medical Sciences New Delhi India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4800-5826","authenticated-orcid":false,"given":"Shikha","family":"Goja","sequence":"additional","affiliation":[{"name":"Department of Cardiothoracic and Vascular Surgery All India Institute of Medical Sciences New Delhi India"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2022,2,11]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jtcvs.2017.03.049"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.athoracsur.2018.06.020"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.95.5.1207"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0003-4975(01)03171-X"},{"key":"e_1_2_10_6_1","unstructured":"JacobsJP JacobsML MavroudisC et al. Executive summary: The Society of Thoracic Surgeons Congenital Heart Surgery Database\u2014twenty\u2010sixth harvest\u2014(January 1 2013\u2013December 31 2016). The Society of Thoracic Surgeons (STS) and Duke University Medical Center Durham NC; 2017."},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0003-4975(99)01270-9"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.1017\/S1047951108002813"},{"key":"e_1_2_10_9_1","unstructured":"JacobsJP JacobsML MavroudisC et al. Executive summary: The Society of Thoracic Surgeons congenital heart surgery database\u2014twelfth harvest (January 1 2006\u2013December 31 2009). The Society of Thoracic Surgeons and Duke Clinical Research Institute Duke University Medical Center Durham NC; 2010."},{"key":"e_1_2_10_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.athoracsur.2011.06.008"},{"key":"e_1_2_10_11_1","first-page":"339","volume-title":"Congenital Heart Disease: Causes and Processes","author":"Becker AE","year":"1984"},{"key":"e_1_2_10_12_1","doi-asserted-by":"publisher","DOI":"10.1002\/ar.24020"},{"key":"e_1_2_10_13_1","article-title":"A pictorial account of heart development: spatial and temporal aspects of the human embryonic heart between 3.5 and 8 weeks of development","author":"Hikspoors JPJM","year":"2021","journal-title":"Commun\u00a0Biol"},{"key":"e_1_2_10_14_1","doi-asserted-by":"publisher","DOI":"10.1152\/physrev.00006.2003"},{"key":"e_1_2_10_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cjca.2017.01.017"},{"key":"e_1_2_10_16_1","doi-asserted-by":"publisher","DOI":"10.3390\/jcdd6010009"},{"key":"e_1_2_10_17_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13023-019-1044-2"},{"key":"e_1_2_10_18_1","doi-asserted-by":"publisher","DOI":"10.1136\/hrt.43.3.332"},{"key":"e_1_2_10_19_1","first-page":"793","article-title":"Les voies de conduction auriculo\u2010ventriculaires dans le tetralogie de Fallot","volume":"8","author":"Anderson RH","year":"1977","journal-title":"Coeur"}],"container-title":["Journal of Cardiac Surgery"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/jocs.16242","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/jocs.16242","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/jocs.16242","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,11,26]],"date-time":"2025-11-26T16:32:14Z","timestamp":1764174734000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/jocs.16242"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,2,11]]},"references-count":18,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2022,5]]}},"alternative-id":["10.1111\/jocs.16242"],"URL":"https:\/\/doi.org\/10.1111\/jocs.16242","archive":["Portico"],"relation":{},"ISSN":["0886-0440"],"issn-type":[{"value":"0886-0440","type":"print"}],"subject":[],"published":{"date-parts":[[2022,2,11]]},"assertion":[{"value":"2021-09-20","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2021-11-02","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2022-02-11","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}