{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,9]],"date-time":"2026-10-09T08:51:15Z","timestamp":1791535875846,"version":"4.3.4"},"reference-count":18,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2022,2,26]],"date-time":"2022-02-26T00:00:00Z","timestamp":1645833600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Journal of Cardiac Surgery"],"published-print":{"date-parts":[[2022,5]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>\n                      Severe mitral regurgitation (MR) is associated with progressive heart failure and impairment of survival. Degenerative MR accounts for most MV repair surgeries. Conventional mitral valve repair surgery requires cardiopulmonary bypass and is associated with significant morbidity and risks. Transapical beating\u2010heart mitral valve repair by artificial chordae implantation with transesophageal echocardiography (TEE) guidance has the potential to significantly reduce surgical morbidity. We report the first\u2010in\u2010human experience of degenerative MR repair using a novel artificial chordae implantation device (Mitralstitch\n                      <jats:sup>TM<\/jats:sup>\n                      system).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Ten patients with severe MR underwent transapical artificial chordae implantation using MitralstitchTM system. The procedure was performed through a small left thoracotomy under general anesthesia and TEE guidance. Patients underwent transthoracic echocardiography and other assessments during the follow\u2010up.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>All 10 patients with an average age of 63.7\u2009\u00b1\u20099.6 years successfully received transapical artificial chordae implantation. Their MR reduced from severe to none or trace in five patients, mild in five patients before discharge. Five patients received one artificial chordal implantation, four patients received two, and one patient received three and edge\u2010to\u2010edge repair by locking two of them. The safety and efficacy endpoint were achieved in all patients at 1\u2010month follow\u2010up. At 1\u2010year follow\u2010up, six patients had mild MR, three patients had moderate MR, one patient had recurrence of severe MR and underwent surgical repair.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>The results of this first\u2010in\u2010human study show safety and feasibility of transapical mitral valve repair using MitralStitch system. Patient selection and technical refinement are crucial to improve the outcomes.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/jocs.16342","type":"journal-article","created":{"date-parts":[[2022,2,26]],"date-time":"2022-02-26T22:57:57Z","timestamp":1645916277000},"page":"1242-1249","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Initial experiences of transapical beating\u2010heart mitral valve repair with a novel artificial chordal implantation device"],"prefix":"10.1155","volume":"37","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1856-7825","authenticated-orcid":false,"given":"Shouzheng","family":"Wang","sequence":"first","affiliation":[{"name":"Department of Cardiovascular Surgery, Structural Heart Disease Center, National Center for Cardiovascular Disease, China &amp; Fuwai Cardiovascular Hospital Chinese Academy of Medical Sciences Beijing China"},{"name":"Department of Structural Heart Disease The Fuwai Yunnan Cardiovascular Hospital Kunming China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xu","family":"Meng","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular Surgery, Beijing Anzhen Hospital Capital Medical University Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shengshou","family":"Hu","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular Surgery, Structural Heart Disease Center, National Center for Cardiovascular Disease, China &amp; Fuwai Cardiovascular Hospital Chinese Academy of Medical Sciences Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Horst","family":"Sievert","sequence":"additional","affiliation":[{"name":"Cardiovascular Center Frankfurt CVC Frankfurt Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yongquan","family":"Xie","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular Surgery, Structural Heart Disease Center, National Center for Cardiovascular Disease, China &amp; Fuwai Cardiovascular Hospital Chinese Academy of Medical Sciences Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaopeng","family":"Hu","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular Surgery, Structural Heart Disease Center, National Center for Cardiovascular Disease, China &amp; Fuwai Cardiovascular Hospital Chinese Academy of Medical Sciences Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yi","family":"Sun","sequence":"additional","affiliation":[{"name":"Department of Structural Heart Disease The Fuwai Yunnan Cardiovascular Hospital Kunming China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhiling","family":"Luo","sequence":"additional","affiliation":[{"name":"Department of Ultrasound The Fuwai Yunnan Cardiovascular Hospital Kunming China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hongyan","family":"Zhou","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular Surgery, Structural Heart Disease Center, National Center for Cardiovascular Disease, China &amp; Fuwai Cardiovascular Hospital Chinese Academy of Medical Sciences Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guimin","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Structural Heart Disease The Fuwai Yunnan Cardiovascular Hospital Kunming China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiangbin","family":"Pan","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular Surgery, Structural Heart Disease Center, National Center for Cardiovascular Disease, China &amp; Fuwai Cardiovascular Hospital Chinese Academy of Medical Sciences Beijing China"},{"name":"Department of Structural Heart Disease The Fuwai Yunnan Cardiovascular Hospital Kunming China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2022,2,26]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(16)00558-4"},{"key":"e_1_2_9_3_1","first-page":"1724","article-title":"Five\u2010year epidemiological survey of valvular heart disease: changes in morbidity, etiological spectrum and management in a cardiovascular center of Southern China","volume":"6","author":"Liu FZ","year":"2014","journal-title":"J Thorac Dis"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jtcvs.2012.05.030"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jtcvs.2015.06.022"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIR.0000000000000503"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1806640"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2017.09.015"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1540-8191.1989.tb00291.x"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jtcvs.2008.07.028"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijcard.2015.11.131"},{"key":"e_1_2_9_12_1","first-page":"23","article-title":"An early European experience with transapical off\u2010pump mitral valve repair with NeoChord implantation","volume":"204","author":"Colli A","year":"2018","journal-title":"Eur J Cardiothorac Surg"},{"key":"e_1_2_9_13_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.116.022010"},{"key":"e_1_2_9_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jtcvs.2013.08.012"},{"key":"e_1_2_9_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2017.10.062"},{"key":"e_1_2_9_16_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.118.033509"},{"key":"e_1_2_9_17_1","doi-asserted-by":"publisher","DOI":"10.21037\/acs-2020-mv-86"},{"key":"e_1_2_9_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jtcvs.2018.02.008"},{"key":"e_1_2_9_19_1","doi-asserted-by":"publisher","DOI":"10.1093\/ejcts\/ezz048"}],"container-title":["Journal of Cardiac Surgery"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/jocs.16342","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/jocs.16342","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/jocs.16342","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,11,26]],"date-time":"2025-11-26T16:31:45Z","timestamp":1764174705000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/jocs.16342"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,2,26]]},"references-count":18,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2022,5]]}},"alternative-id":["10.1111\/jocs.16342"],"URL":"https:\/\/doi.org\/10.1111\/jocs.16342","archive":["Portico"],"relation":{},"ISSN":["0886-0440"],"issn-type":[{"value":"0886-0440","type":"print"}],"subject":[],"published":{"date-parts":[[2022,2,26]]},"assertion":[{"value":"2021-06-28","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2021-09-28","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2022-02-26","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}