{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,10]],"date-time":"2026-10-10T06:59:25Z","timestamp":1791615565537,"version":"4.3.4"},"reference-count":74,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2022,6,2]],"date-time":"2022-06-02T00:00:00Z","timestamp":1654128000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Journal of Cardiac Surgery"],"published-print":{"date-parts":[[2022,9]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>There is emerging evidence to support pre\u2010emptive thoracic endovascular aortic repair (TEVAR) intervention for uncomplicated type B aortic dissection (unTBAD). Pre\u2010emptive intervention would be particularly beneficial in patients that have a higher baseline risk of progressing to complicated TBAD (coTBAD). There remain debate on the optimal clinical, laboratory, morphological, and radiological parameters, which would identify the highest\u2010risk patients that would benefit most from pre\u2010emptive TEVAR.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Aim<\/jats:title>\n                    <jats:p>This review summarizes evidence on the clinical, laboratory, and morphological parameters that increase the risk profiles of unTBAD patients.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>A comprehensive literature search was carried out on multiple electronic databases including PubMed, EMBASE, Ovid, and Scopus to collate all research evidence on the clinical, laboratory, and morphological parameters that increase the risk profiles of unTBAD patients<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>At present, there are no clear clinical guidelines using risk\u2010stratification to inform the selection of unTBAD patients for TEVAR. However, there are noticeable literature trends that can assist with the identification of the most at\u2010risk unTBAD patients. Patients are at particular risk when they have refractory pain and\/or hypertension, elevated C\u2010reactive protein (CRP), larger aortic diameter, and larger entry tears. These risks should be considered alongside factors that increase the procedural risk of TEVAR to create a well\u2010balanced approach. Advances in biomarkers and imaging are likely to identify more pertinent parameters in the future to optimize the development of balanced, risk\u2010stratified treatment protocols.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>There are a variety of risk profiling parameters that can be used to identify the high\u2010risk unTBAD patient, with novel biomarkers and imaging parameters emerging. Longer\u2010term evidence verifying these parameters would be ideal. Further randomized controlled trials and multicentre registry analyses are also warranted to guide risk\u2010stratified selection protocols.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/jocs.16655","type":"journal-article","created":{"date-parts":[[2022,6,2]],"date-time":"2022-06-02T07:22:26Z","timestamp":1654154546000},"page":"2811-2820","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":12,"title":["Risk profile analysis of uncomplicated type B aortic dissection patients undergoing thoracic endovascular aortic repair: Laboratory and\u00a0radiographic predictors"],"prefix":"10.1155","volume":"37","author":[{"given":"Alexander","family":"Geragotellis","sequence":"first","affiliation":[{"name":"University of Cape Town Medical School Cape Town South Africa"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2111-8596","authenticated-orcid":false,"given":"Mohammed","family":"Al\u2010Tawil","sequence":"additional","affiliation":[{"name":"Faculty of Medicine Al\u2010Quds University Jerusalem Palestine"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6725-6164","authenticated-orcid":false,"given":"Matti","family":"Jubouri","sequence":"additional","affiliation":[{"name":"Hull York Medical School University of York York UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sven Z. 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