{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,16]],"date-time":"2026-10-16T01:02:14Z","timestamp":1792112534444,"version":"4.4.0"},"reference-count":38,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2013,3,17]],"date-time":"2013-03-17T00:00:00Z","timestamp":1363478400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J of Obstet and Gynaecol"],"published-print":{"date-parts":[[2013,5]]},"abstract":"Abstract<\/jats:title>Aim<\/jats:title>To determine whether maternal serum placental growth factor (PlGF<\/jats:styled-content>) estimation in early second trimester (20\u201322 weeks of gestation) can predict the occurrence of early onset preeclampsia and\/or early onset intrauterine growth restriction (IUGR<\/jats:styled-content>).<\/jats:p><\/jats:sec>Material and Methods<\/jats:title>A prospective cohort study was conducted on 722 women with singleton pregnancies, screened from the antenatal clinic, and serum PlGF<\/jats:styled-content> levels were estimated at 20\u201322 weeks of gestation. A cut\u2010off value of <155\u2009pg\/mL for serum PlGF<\/jats:styled-content> was determined by receiver operating characteristic (ROC<\/jats:styled-content>) curve analysis for identifying pregnant women at risk of developing early onset preeclampsia and\/or early onset IUGR<\/jats:styled-content>. Preeclampsia and IUGR<\/jats:styled-content> were classified as early onset when diagnosed by 32 weeks of gestation. Univariate logistic regression analysis was used to analyze the association between serum PlGF<\/jats:styled-content> level <155\u2009pg\/mL and the two outcome measures (i.e. early onset preeclampsia and early onset IUGR<\/jats:styled-content>) and odds ratio (OR<\/jats:styled-content>) was computed. P<\/jats:italic>\u2010value\u2009<\u20090.05 was considered statistically significant.<\/jats:p><\/jats:sec>Results<\/jats:title>Maternal serum PlGF<\/jats:styled-content> level <155\u2009pg\/mL at 20\u201322 weeks of gestation had a strong association with early onset preeclampsia (OR<\/jats:styled-content> 8.35; 95% CI<\/jats:styled-content> 1.79\u201318.94; P<\/jats:italic>\u2009=\u20090.007) and with early onset IUGR<\/jats:styled-content> (OR<\/jats:styled-content> 10.73; 95% CI<\/jats:styled-content> 4.08\u201320.23; P<\/jats:italic>\u2009=\u20090.000). The sensitivity of serum PlGF<\/jats:styled-content>\u2009<\u2009155\u2009pg\/mL for predicting early onset preeclampsia and early onset IUGR<\/jats:styled-content> were 82 and 84, respectively.<\/jats:p><\/jats:sec>Conclusion<\/jats:title>Maternal serum PlGF<\/jats:styled-content> level estimation in early second trimester (20\u201322 weeks of gestation) may be useful in predicting the occurrence of early onset preeclampsia and\/or early onset IUGR.<\/jats:styled-content><\/jats:p><\/jats:sec>","DOI":"10.1111\/jog.12006","type":"journal-article","created":{"date-parts":[[2013,3,18]],"date-time":"2013-03-18T02:32:33Z","timestamp":1363573953000},"page":"881-890","source":"Crossref","is-referenced-by-count":21,"title":["Can maternal serum placental growth factor estimation in early second trimester predict the occurrence of early onset preeclampsia and\/or early onset intrauterine growth restriction? A prospective cohort study"],"prefix":"10.1111","volume":"39","author":[{"given":"Sanjib Kumar","family":"Ghosh","sequence":"first","affiliation":[{"name":"Department of Anatomy Lady Hardinge Medical College and Smt. Sucheta Kriplani Hospital New Delhi India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shashi","family":"Raheja","sequence":"additional","affiliation":[{"name":"Department of Anatomy Lady Hardinge Medical College and Smt. Sucheta Kriplani Hospital New Delhi India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anita","family":"Tuli","sequence":"additional","affiliation":[{"name":"Department of Anatomy Lady Hardinge Medical College and Smt. Sucheta Kriplani Hospital New Delhi India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chitra","family":"Raghunandan","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology Lady Hardinge Medical College and Smt. Sucheta Kriplani Hospital New Delhi India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sneh","family":"Agarwal","sequence":"additional","affiliation":[{"name":"Department of Anatomy Lady Hardinge Medical College and Smt. Sucheta Kriplani Hospital New Delhi India"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2013,3,17]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1081\/PRG-100100138"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(05)17987-2"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajog.2006.01.014"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajog.2005.07.049"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1002\/uog.3930"},{"key":"e_1_2_7_7_1","doi-asserted-by":"crossref","first-page":"25646","DOI":"10.1016\/S0021-9258(18)47298-5","article-title":"Placental growth factor. 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