{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,1]],"date-time":"2026-04-01T15:49:17Z","timestamp":1775058557694,"version":"3.50.1"},"reference-count":25,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2013,4,3]],"date-time":"2013-04-03T00:00:00Z","timestamp":1364947200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J of Obstet and Gynaecol"],"published-print":{"date-parts":[[2013,5]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Aim<\/jats:title><jats:p>In recent years, both dienogest, a fourth\u2010generation progestin, and levonorgestrel\u2010releasing intrauterine device have been found to be effective in terms of endometriosis\u2010related pelvic pain improvement. No data, however, are available about their efficacy in terms of postoperative recurrence prevention in women recently submitted to surgery for endometriosis at every stage. Our objective was to compare two postoperative medical approaches for pain control and reduction of recurrences in patients undergoing surgery for endometriosis.<\/jats:p><\/jats:sec><jats:sec><jats:title>Material and Methods<\/jats:title><jats:p>Ninety\u2010two patients undergoing surgery for endometriosis and subsequent treatment by estradiol valerate\u2009+\u2009dienogest (<jats:styled-content style=\"fixed-case\">EP<\/jats:styled-content>) (group <jats:styled-content style=\"fixed-case\">A<\/jats:styled-content>) or levonorgestrel\u2010releasing uterine device (<jats:styled-content style=\"fixed-case\">LNG\u2010IUD<\/jats:styled-content>) (Group <jats:styled-content style=\"fixed-case\">B<\/jats:styled-content>) between <jats:styled-content style=\"fixed-case\">J<\/jats:styled-content>anuary 2009 and <jats:styled-content style=\"fixed-case\">J<\/jats:styled-content>une 2010 were retrospectively analyzed. The primary endpoints were pain relapse and disease recurrence rate at 12 and 24 months. The secondary endpoint was patient satisfaction with the therapy at 24 months.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Forty\u2010eight patients in Group <jats:styled-content style=\"fixed-case\">A<\/jats:styled-content> and 44 in Group <jats:styled-content style=\"fixed-case\">B<\/jats:styled-content> were examined. At 12 and 24 months a statistically greater reduction both in <jats:styled-content style=\"fixed-case\">Ca125<\/jats:styled-content> levels and <jats:styled-content style=\"fixed-case\">VAS<\/jats:styled-content> score was seen in women treated with <jats:styled-content style=\"fixed-case\">EP<\/jats:styled-content> compared to <jats:styled-content style=\"fixed-case\">LNG\u2010IUD<\/jats:styled-content>. The recurrence rate at 12 and 24 months follow\u2010up was slightly lower, but not at a significant level, in Group <jats:styled-content style=\"fixed-case\">A<\/jats:styled-content> than in Group <jats:styled-content style=\"fixed-case\">B<\/jats:styled-content>. Finally, satisfaction with treatment at 24 months was significantly higher in Group <jats:styled-content style=\"fixed-case\">B<\/jats:styled-content>.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p><jats:styled-content style=\"fixed-case\">EP<\/jats:styled-content> administration is significantly more effective than <jats:styled-content style=\"fixed-case\">LNG\u2010IUD<\/jats:styled-content> in reducing pelvic pain and more effective in reducing recurrence rate but not at a significant level. <jats:styled-content style=\"fixed-case\">LNG\u2010IUD<\/jats:styled-content>, however, has significantly higher patient satisfaction.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jog.12030","type":"journal-article","created":{"date-parts":[[2013,4,4]],"date-time":"2013-04-04T07:41:56Z","timestamp":1365061316000},"page":"985-990","source":"Crossref","is-referenced-by-count":44,"title":["Postoperative administration of dienogest plus estradiol valerate versus levonorgestrel\u2010releasing intrauterine device for prevention of pain relapse and disease recurrence in endometriosis patients"],"prefix":"10.1111","volume":"39","author":[{"given":"Michele","family":"Morelli","sequence":"first","affiliation":[{"name":"Department of Obstetrics and Gynecology \u2018Magna Graecia\u2019 University  Catanzaro Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Angela","family":"Sacchinelli","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology \u2018Magna Graecia\u2019 University  Catanzaro Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Roberta","family":"Venturella","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology \u2018Magna Graecia\u2019 University  Catanzaro Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rita","family":"Mocciaro","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and 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