{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,8]],"date-time":"2026-09-08T12:34:28Z","timestamp":1788870868127,"version":"build-2803163510"},"reference-count":30,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2013,6,26]],"date-time":"2013-06-26T00:00:00Z","timestamp":1372204800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100012166","name":"National Basic Research Program of China","doi-asserted-by":"crossref","award":["2010CB529403"],"award-info":[{"award-number":["2010CB529403"]}],"id":[{"id":"10.13039\/501100012166","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J of Obstet and Gynaecol"],"published-print":{"date-parts":[[2013,7]]},"abstract":"Abstract<\/jats:title>\n \n Aim<\/jats:title>\n \n Lymph node metastasis is one of the predictive factors associated with poor prognosis of epithelial ovarian cancer. To clarify the role of\n CD<\/jats:styled-content>\n 34 and vascular endothelial growth factor receptor\u20103\u2010positive (\n CD<\/jats:styled-content>\n 34+\/\n VEGFR<\/jats:styled-content>\n 3+) lymphatic\/vascular endothelial progenitor cells (\n LVEPC<\/jats:styled-content>\n ) in patients with lymph node metastasis and epithelial ovarian cancer progression, the levels of circulating\n CD<\/jats:styled-content>\n 34+\/\n VEGFR<\/jats:styled-content>\n 3+\n LVEPC<\/jats:styled-content>\n in epithelial ovarian cancer patients were detected. We also tested the plasma protein levels of\n VEGF<\/jats:styled-content>\n and stromal cell\u2010derived factor to find out their possible relationships with lymph node metastasis in our epithelial ovarian cancer cohort.\n <\/jats:p>\n <\/jats:sec>\n \n Material and Methods<\/jats:title>\n \n Peripheral blood samples were collected from 54 patients diagnosed as epithelial ovarian cancer, and 31 normal samples as control. The circulating levels of\n LVEPC<\/jats:styled-content>\n were carried out by flow cytometry, and blood protein levels of biomarkers were measured by enzyme\u2010linked immunosorbent assay (\n ELISA<\/jats:styled-content>\n ).\n <\/jats:p>\n <\/jats:sec>\n \n Results<\/jats:title>\n \n The level of circulating\n LVEPC<\/jats:styled-content>\n was significantly higher in patients with ovarian cancer compared with that of healthy controls. There was also a statistically significant correlation between\n LVEPC<\/jats:styled-content>\n levels and surgical staging of epithelial ovarian cancer (\n P<\/jats:italic>\n \u2009<\u20090.01).\n <\/jats:p>\n <\/jats:sec>\n \n Conclusion<\/jats:title>\n \n The circulating levels of bone marrow\u2010derived\n LVEPC<\/jats:styled-content>\n are significantly increased in epithelial ovarian cancer patients and these levels correlate with lymph node metastasis too.\n <\/jats:p>\n <\/jats:sec>","DOI":"10.1111\/jog.12047","type":"journal-article","created":{"date-parts":[[2013,6,26]],"date-time":"2013-06-26T21:56:31Z","timestamp":1372283791000},"page":"1268-1275","source":"Crossref","is-referenced-by-count":16,"title":["High levels of circulating\n CD<\/scp>\n 34+\/\n VEGFR<\/scp>\n 3+ lymphatic\/vascular endothelial progenitor cells is correlated with lymph node metastasis in patients with epithelial ovarian cancer"],"prefix":"10.1111","volume":"39","author":[{"given":"Huiling","family":"Qiu","sequence":"first","affiliation":[{"name":"Department of Obstetrics and Gynecology Southwest Hospital Third Military Medical University Chongqing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lili","family":"Cao","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology Southwest Hospital Third Military Medical University Chongqing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dan","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology Southwest Hospital Third Military Medical University Chongqing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Huicheng","family":"Xu","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology Southwest Hospital Third Military Medical University Chongqing 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