{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,26]],"date-time":"2025-10-26T20:36:15Z","timestamp":1761510975015},"reference-count":23,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2013,6,26]],"date-time":"2013-06-26T00:00:00Z","timestamp":1372204800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J of Obstet and Gynaecol"],"published-print":{"date-parts":[[2013,7]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Aim<\/jats:title><jats:p>The aim of this study was to investigate the effect of bilateral ovariectomy (<jats:styled-content style=\"fixed-case\">OVX<\/jats:styled-content>), 17\u2010beta estradiol (<jats:styled-content style=\"fixed-case\">E<\/jats:styled-content>2), and progesterone (<jats:styled-content style=\"fixed-case\">P<\/jats:styled-content>4) on the histology and estrogen receptor (<jats:styled-content style=\"fixed-case\">ER<\/jats:styled-content>) expression of the bladder using a female partial bladder outlet obstruction (<jats:styled-content style=\"fixed-case\">pBOO<\/jats:styled-content>) rat model.<\/jats:p><\/jats:sec><jats:sec><jats:title>Material and Methods<\/jats:title><jats:p>A total of 60 female <jats:styled-content style=\"fixed-case\">S<\/jats:styled-content>prague\u2013<jats:styled-content style=\"fixed-case\">D<\/jats:styled-content>awley rats were evenly assigned into six groups of 10 each. Group <jats:styled-content style=\"fixed-case\">A<\/jats:styled-content> served as the control. Groups <jats:styled-content style=\"fixed-case\">B<\/jats:styled-content>\u2013<jats:styled-content style=\"fixed-case\">F<\/jats:styled-content> underwent induced <jats:styled-content style=\"fixed-case\">pBOO<\/jats:styled-content>. Groups <jats:styled-content style=\"fixed-case\">C<\/jats:styled-content>\u2013<jats:styled-content style=\"fixed-case\">F<\/jats:styled-content> underwent <jats:styled-content style=\"fixed-case\">OVX<\/jats:styled-content>. Groups <jats:styled-content style=\"fixed-case\">D<\/jats:styled-content>\u2013<jats:styled-content style=\"fixed-case\">F<\/jats:styled-content> were given <jats:styled-content style=\"fixed-case\">E<\/jats:styled-content>2 (0.1\u2009mg\/kg\/day), <jats:styled-content style=\"fixed-case\">G<\/jats:styled-content>roup <jats:styled-content style=\"fixed-case\">E<\/jats:styled-content> was given <jats:styled-content style=\"fixed-case\">P<\/jats:styled-content>4 (1\u2009mg\/kg\/day), and Group <jats:styled-content style=\"fixed-case\">F<\/jats:styled-content> was given <jats:styled-content style=\"fixed-case\">P<\/jats:styled-content>4 and dehydroepiandrosterone (<jats:styled-content style=\"fixed-case\">DHEA<\/jats:styled-content>) (300\u2009\u03bcg\/kg\/day) by an <jats:styled-content style=\"fixed-case\">A<\/jats:styled-content>lzet pump. Four weeks later, serum <jats:styled-content style=\"fixed-case\">E<\/jats:styled-content>2 and <jats:styled-content style=\"fixed-case\">P<\/jats:styled-content>4 levels were evaluated. Each rat was anesthetized and the urinary bladder was removed for weighing and histological study.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Expression of <jats:styled-content style=\"fixed-case\">ER<\/jats:styled-content>\u2010\u03b2 was not significantly different between the control group and the other study groups. <jats:styled-content style=\"fixed-case\">pBOO<\/jats:styled-content> was shown to increase both bladder weight and detrusor muscle thickness. <jats:styled-content style=\"fixed-case\">OVX<\/jats:styled-content> had an additive effect to <jats:styled-content style=\"fixed-case\">BOO<\/jats:styled-content> on increased blood vessel density in the bladder. <jats:styled-content style=\"fixed-case\">E<\/jats:styled-content>2 was shown to increase blood vessel density, while <jats:styled-content style=\"fixed-case\">P<\/jats:styled-content>4 supplementation decreased blood vessel density. <jats:styled-content style=\"fixed-case\">DHEA<\/jats:styled-content> did not cause any significant effects on blood vessel density.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Hormone therapy did not change the expression of <jats:styled-content style=\"fixed-case\">ER<\/jats:styled-content> in bladder outlet obstruction. Estradiol stimulated the increased angiogenesis of the bladder detrusor but <jats:styled-content style=\"fixed-case\">P4<\/jats:styled-content> decreased the angiogenesis of the bladder detrusor. <jats:styled-content style=\"fixed-case\">DHEA<\/jats:styled-content> had no effect on the bladder detrusor.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jog.12057","type":"journal-article","created":{"date-parts":[[2013,6,27]],"date-time":"2013-06-27T01:56:31Z","timestamp":1372298191000},"page":"1259-1267","source":"Crossref","is-referenced-by-count":4,"title":["Effect of ovariectomy, 17\u2010beta estradiol, and progesterone on histology and estrogen receptors of bladder in female partial bladder outlet obstruction rat model"],"prefix":"10.1111","volume":"39","author":[{"given":"Il Dong","family":"Kim","sequence":"first","affiliation":[{"name":"Department of Obstetrics and Gynecology Grace Women's Hospital  Koyang Republic of Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ki Hoon","family":"Ahn","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology College of Medicine Korea University  Seoul Republic of Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sanghoon","family":"Lee","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology College of Medicine Korea University  Seoul Republic of Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Soon Cheol","family":"Hong","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology College of Medicine Korea University  Seoul Republic of Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sun Haeng","family":"Kim","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology College of Medicine Korea University  Seoul Republic of Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tak","family":"Kim","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology College of Medicine Korea University  Seoul Republic of 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