{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,5,24]],"date-time":"2025-05-24T20:22:37Z","timestamp":1748118157368},"reference-count":18,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2013,7,2]],"date-time":"2013-07-02T00:00:00Z","timestamp":1372723200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"Roche Diagnostics K.K., Tokyo, Japan"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J of Obstet and Gynaecol"],"published-print":{"date-parts":[[2013,8]]},"abstract":"Abstract<\/jats:title>Aim<\/jats:title>The aim of this study was to evaluate the clinical performance of the A<\/jats:styled-content>mplicor HPV<\/jats:styled-content> test, which detects 13 high\u2010risk human papillomaviruses (HR<\/jats:styled-content>\u2010HPV)<\/jats:styled-content>, and to determine the association between consistent HR\u2010HPV<\/jats:styled-content> infection and progression of cervical intraepithelial neoplasia (CIN<\/jats:styled-content>) 2 to CIN3<\/jats:styled-content>.<\/jats:p><\/jats:sec>Material and Methods<\/jats:title>This multi\u2010institutional prospective study enrolled 122 women diagnosed with CIN2<\/jats:styled-content> by central pathological review. Subjects were tested at study entry and every 6 months over a 24\u2010month period by cytology, A<\/jats:styled-content>mplicor HPV<\/jats:styled-content> test and colposcopy. Central pathological review was performed at the end of the study or if CIN<\/jats:styled-content> progression was suspected.<\/jats:p><\/jats:sec>Results<\/jats:title>Ninety\u2010three of the 122 participants completed all tests in the study and were included in the analysis. HR\u2010HPV<\/jats:styled-content> was detected in 87\/93 (93.5%) participants at study entry. Twenty\u2010four of the 87 HR\u2010HPV<\/jats:styled-content>\u2010positive participants progressed to \u2265CIN3<\/jats:styled-content>, compared with none of the six participants who were HR\u2010HPV<\/jats:styled-content>\u2010negative at study entry. The positive predictive value, negative predictive value, sensitivity and specificity of the A<\/jats:styled-content>mplicor HPV<\/jats:styled-content> test at study entry for predicting \u2265CIN3<\/jats:styled-content> progression were 27.6%, 100%, 100% and 8.7%, respectively. Sixty\u2010two participants were HR\u2010HPV<\/jats:styled-content>\u2010positive from study entry through to study completion, 24 of whom progressed to \u2265CIN3<\/jats:styled-content>. None of 31 participants without continuous HR\u2010HPV<\/jats:styled-content> detection progressed to \u2265CIN3<\/jats:styled-content>. For continuous HR\u2010HPV<\/jats:styled-content> detection, the positive predictive value, negative predictive value, sensitivity and specificity of the A<\/jats:styled-content>mplicor HPV<\/jats:styled-content> test were 38.7%, 100%, 100% and 44.9%, respectively.<\/jats:p><\/jats:sec>Conclusions<\/jats:title>All participants who progressed to \u2265CIN3<\/jats:styled-content> were continuously HR\u2010HPV<\/jats:styled-content>\u2010positive. The A<\/jats:styled-content>mplicor HPV<\/jats:styled-content> test thus demonstrated a good performance for predicting CIN3<\/jats:styled-content> progression.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jog.12068","type":"journal-article","created":{"date-parts":[[2013,7,2]],"date-time":"2013-07-02T04:57:49Z","timestamp":1372741069000},"page":"1347-1353","source":"Crossref","is-referenced-by-count":1,"title":["Prospective evaluation of the A<\/scp>mplicor HPV test for predicting progression of cervical intraepithelial neoplasia 2"],"prefix":"10.1111","volume":"39","author":[{"given":"Takayoshi","family":"Nogawa","sequence":"first","affiliation":[{"name":"Department of Gynecology National Hospital Organization Shikoku Cancer Center Matsuyama"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Masamichi","family":"Hiura","sequence":"additional","affiliation":[{"name":"Department of Gynecology National Hospital Organization Shikoku Cancer Center Matsuyama"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hideyuki","family":"Tanaka","sequence":"additional","affiliation":[{"name":"Roche Diagnostics K.K. 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