{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,19]],"date-time":"2026-08-19T19:04:26Z","timestamp":1787166266682,"version":"build-2736575974"},"reference-count":17,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2013,7,2]],"date-time":"2013-07-02T00:00:00Z","timestamp":1372723200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J of Obstet and Gynaecol"],"published-print":{"date-parts":[[2013,10]]},"abstract":"Abstract<\/jats:title>\n \n Aim<\/jats:title>\n \n To elicit the diagnostic value of smaller than expected crown\u2013rump length (\n CRL<\/jats:styled-content>\n ) to predict the occurrence of subsequent miscarriage in women with a viable first trimester pregnancy.\n <\/jats:p>\n <\/jats:sec>\n \n Methods<\/jats:title>\n \n A cohort study was conducted in the fetal special care unit of a tertiary care maternity hospital. The recruited participants were young pregnant women at 6\u201313 weeks of gestation. Transvaginal ultrasonography was performed to determine pregnancy viability and measure the embryonic\n CRL<\/jats:styled-content>\n . To compare the differences in\n CRL<\/jats:styled-content>\n between those pregnancies that remained viable and those that subsequently miscarried, the deviation of observed and expected\n CRL<\/jats:styled-content>\n was calculated and expressed in standard deviations (\n SD<\/jats:styled-content>\n ) as Z score. The primary outcome measure was the percentage of pregnancies with antecedent growth delay that miscarried by the end of the first trimester.\n <\/jats:p>\n <\/jats:sec>\n \n Results<\/jats:title>\n \n Of the pregnancies that subsequently miscarried, 79.3% (42\/53) had smaller than expected\n CRL<\/jats:styled-content>\n , and in 56.6% (30\/53) the\n CRL<\/jats:styled-content>\n was 2\u2009\n SD<\/jats:styled-content>\n or less from that expected for gestational age (\n GA<\/jats:styled-content>\n ). The mean Z score for\n CRL<\/jats:styled-content>\n was significantly lower in pregnancies that subsequently miscarried compared to pregnancies that remained viable (\u22122.9\u2009\u00b1\u20092.6 vs \u22120.8\u2009\u00b1\u20092.1, respectively,\n P<\/jats:italic>\n \u2009<\u20090.001). A\n CRL<\/jats:styled-content>\n of 2\u2009\n SD<\/jats:styled-content>\n or less from that expected for\n GA<\/jats:styled-content>\n as a cut\u2010off point had a sensitivity of 56.6, specificity of 81.9, positive predictive value of 36.6, negative predictive value of 91.1, likelihood ratio positive of 3.1 and likelihood ratio negative of 0.5 in predicting subsequent miscarriage.\n <\/jats:p>\n <\/jats:sec>\n \n Conclusion<\/jats:title>\n \n Viable first trimester pregnancies with small for\n GA CRL<\/jats:styled-content>\n were associated with a higher probability of a subsequent miscarriage.\n <\/jats:p>\n <\/jats:sec>","DOI":"10.1111\/jog.12082","type":"journal-article","created":{"date-parts":[[2013,7,2]],"date-time":"2013-07-02T05:05:22Z","timestamp":1372741522000},"page":"1449-1455","source":"Crossref","is-referenced-by-count":17,"title":["Can a smaller than expected crown\u2013rump length reliably predict the occurrence of subsequent miscarriage in a viable first trimester pregnancy?"],"prefix":"10.1111","volume":"39","author":[{"given":"Wessam M.","family":"Abuelghar","sequence":"first","affiliation":[{"name":"Obstetrics and Gynecology Department Ain\u2010Shams University"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hisham M.","family":"Fathi","sequence":"additional","affiliation":[{"name":"Obstetrics and Gynecology Department Ain\u2010Shams University"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mohamed I.","family":"Ellaithy","sequence":"additional","affiliation":[{"name":"Obstetrics and Gynecology Department Ain\u2010Shams University"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mohammad A.","family":"Anwar","sequence":"additional","affiliation":[{"name":"Obstetrics and Gynecology Department International Medical Center Cairo 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