{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,20]],"date-time":"2026-01-20T10:30:41Z","timestamp":1768905041132,"version":"3.49.0"},"reference-count":17,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2013,7,15]],"date-time":"2013-07-15T00:00:00Z","timestamp":1373846400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J of Obstet and Gynaecol"],"published-print":{"date-parts":[[2013,11]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Aim<\/jats:title><jats:p>The aim of this retrospective study was to investigate the relation between perinatal complications in twin pregnancies and the combination of first\u2010trimester maternal serum pregnancy\u2010associated plasma protein\u2010<jats:styled-content style=\"fixed-case\">A<\/jats:styled-content> (<jats:styled-content style=\"fixed-case\">PAPP<\/jats:styled-content>\u2010<jats:styled-content style=\"fixed-case\">A<\/jats:styled-content>) and free beta\u2010human chorionic gonadotrophin (\u03b2\u2010<jats:styled-content style=\"fixed-case\">hCG<\/jats:styled-content>) levels.<\/jats:p><\/jats:sec><jats:sec><jats:title>Material and Methods<\/jats:title><jats:p>The study was conducted at the <jats:styled-content style=\"fixed-case\">P<\/jats:styled-content>erinatology <jats:styled-content style=\"fixed-case\">D<\/jats:styled-content>epartment of <jats:styled-content style=\"fixed-case\">B<\/jats:styled-content>askent <jats:styled-content style=\"fixed-case\">U<\/jats:styled-content>niversity between <jats:styled-content style=\"fixed-case\">J<\/jats:styled-content>anuary 2005 and <jats:styled-content style=\"fixed-case\">D<\/jats:styled-content>ecember 2011. In total, 104 patients with twin pregnancies were recruited. The association of first\u2010trimester maternal serum\u2010screening markers with perinatal complications was investigated for small\u2010for\u2010gestational\u2010age (<jats:styled-content style=\"fixed-case\">SGA<\/jats:styled-content>) fetuses or intrauterine growth restriction (<jats:styled-content style=\"fixed-case\">IUGR<\/jats:styled-content>), preterm delivery (before 34 weeks of gestation), pregnancy\u2010induced hypertension (<jats:styled-content style=\"fixed-case\">PIH<\/jats:styled-content>), and growth discordance between fetuses.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Low serum <jats:styled-content style=\"fixed-case\">PAPP<\/jats:styled-content>\u2010<jats:styled-content style=\"fixed-case\">A<\/jats:styled-content> (below 10th percentile) levels were not correlated with preterm labor, <jats:styled-content style=\"fixed-case\">PIH<\/jats:styled-content>, or <jats:styled-content style=\"fixed-case\">IUGR<\/jats:styled-content> in twin gestations. Elevated free \u03b2\u2010<jats:styled-content style=\"fixed-case\">hCG<\/jats:styled-content> levels (&gt;90th percentile) were linked to increased rates of <jats:styled-content style=\"fixed-case\">PIH<\/jats:styled-content> and small\u2010for\u2010gestational\u2010age fetuses or <jats:styled-content style=\"fixed-case\">IUGR<\/jats:styled-content>.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Elevated first\u2010trimester free \u03b2\u2010<jats:styled-content style=\"fixed-case\">hCG<\/jats:styled-content> was related to adverse pregnancy outcomes in twin pregnancies, whereas low <jats:styled-content style=\"fixed-case\">PAPP<\/jats:styled-content>\u2010<jats:styled-content style=\"fixed-case\">A<\/jats:styled-content> levels were not linked to adverse pregnancy outcomes.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jog.12091","type":"journal-article","created":{"date-parts":[[2013,7,16]],"date-time":"2013-07-16T04:57:25Z","timestamp":1373950645000},"page":"1495-1499","source":"Crossref","is-referenced-by-count":8,"title":["Obstetrical complications associated with first\u2010trimester screening markers in twin pregnancies"],"prefix":"10.1111","volume":"39","author":[{"given":"Cantekin","family":"Iskender","sequence":"first","affiliation":[{"name":"Department of Obstetrics and Gynecology Baskent University Faculty of Medicine  Adana Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ebru","family":"Tar\u0131m","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology Baskent University Faculty of Medicine  Adana Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tayfun","family":"\u00c7ok","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology 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