{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,13]],"date-time":"2026-03-13T20:23:50Z","timestamp":1773433430560,"version":"3.50.1"},"reference-count":32,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2013,7,22]],"date-time":"2013-07-22T00:00:00Z","timestamp":1374451200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100010438","name":"Poznan University of Medical Sciences","doi-asserted-by":"crossref","id":[{"id":"10.13039\/501100010438","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J of Obstet and Gynaecol"],"published-print":{"date-parts":[[2013,11]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Aim<\/jats:title><jats:p>The aim of this study was to evaluate the role of the serum osteopontin (<jats:styled-content style=\"fixed-case\">OPN<\/jats:styled-content>) level as a biomarker for discriminating between malignant and benign ovarian tumors. Furthermore, comparisons with the diagnostic usefulness of the other tests were performed.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>The study included 114 consecutive women with ovarian tumors (82 benign and 32 malignant) who were referred to our division.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>A cut\u2010off level of 28.0\u2009ng\/mL for <jats:styled-content style=\"fixed-case\">OPN<\/jats:styled-content> showed a sensitivity of 71.87% and a specificity of 89.02%. The area under the receiver\u2013operator curve (<jats:styled-content style=\"fixed-case\">ROC<\/jats:styled-content>) was 0.812. There were no differences in diagnostic utility between <jats:styled-content style=\"fixed-case\">OPN<\/jats:styled-content> and the other studied tests. <jats:styled-content style=\"fixed-case\">OPN<\/jats:styled-content> levels were lower in patients with endometriotic ovarian cysts than in those with other benign ovarian tumors (14.00 vs 19.50\u2009ng\/mL; <jats:italic>P<\/jats:italic>\u2009=\u20090.018). The difference between the median <jats:styled-content style=\"fixed-case\">OPN<\/jats:styled-content> level in patients with endometriotic cysts (14.0\u2009ng\/mL) and those with malignant tumors (40.85\u2009ng\/mL) was also statistically significant (<jats:italic>P<\/jats:italic>\u2009&lt;\u20090.0001). The calculated <jats:styled-content style=\"fixed-case\">OPN<\/jats:styled-content>\/CA\u2010125 ratio was significantly different between patients with endometriotic cysts (median, 0.36; range, 0.05\u20132.89) and those with other benign tumors (median, 1.25; range, 0.05\u20135.70) (<jats:italic>P<\/jats:italic>\u2009=\u20090.0002). There was also a statistically significant difference in the median <jats:styled-content style=\"fixed-case\">OPN\/CA\u2010125<\/jats:styled-content> ratio between patients with endometrial cysts (median, 0.36; range, 0.05\u20132.89) and those with malignant tumors (median, 0.12; range, 0.01\u20133.39) (<jats:italic>P<\/jats:italic>\u2009=\u20090.004).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>The diagnostic utility of <jats:styled-content style=\"fixed-case\">OPN<\/jats:styled-content> is similar to that of ultrasonographic evaluation and <jats:styled-content style=\"fixed-case\">CA\u2010125<\/jats:styled-content> level assessment. Thus, <jats:styled-content style=\"fixed-case\">OPN<\/jats:styled-content> may be useful in differential diagnosis for less experienced ultrasonographers and is especially valuable for differential diagnosis of endometriotic cysts.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jog.12097","type":"journal-article","created":{"date-parts":[[2013,7,23]],"date-time":"2013-07-23T03:16:49Z","timestamp":1374549409000},"page":"1518-1525","source":"Crossref","is-referenced-by-count":21,"title":["Role of osteopontin in differential diagnosis of ovarian tumors"],"prefix":"10.1111","volume":"39","author":[{"given":"Rafal","family":"Moszynski","sequence":"first","affiliation":[{"name":"Division of Gynecological Surgery Poznan University of Medical Sciences  Poznan Poland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sebastian","family":"Szubert","sequence":"additional","affiliation":[{"name":"Division of Gynecological Surgery Poznan University of Medical Sciences  Poznan 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