{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,9]],"date-time":"2026-04-09T23:52:59Z","timestamp":1775778779598,"version":"3.50.1"},"reference-count":50,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2013,7,22]],"date-time":"2013-07-22T00:00:00Z","timestamp":1374451200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"Deanship of Scientific Research, Qassim University, Saudi Arabia"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J of Obstet and Gynaecol"],"published-print":{"date-parts":[[2013,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Aims<\/jats:title><jats:p>The aim of this study was to examine the effect of metformin on serum adiponectin and adiponectin receptor\u20101 (<jats:styled-content style=\"fixed-case\">AdipoR1<\/jats:styled-content>) and evaluate their role in prediction of ovulation in patients with polycystic ovarian syndrome (<jats:styled-content style=\"fixed-case\">PCOS<\/jats:styled-content>).<\/jats:p><\/jats:sec><jats:sec><jats:title>Material and Methods<\/jats:title><jats:p>The study cohort included 68 <jats:styled-content style=\"fixed-case\">PCOS<\/jats:styled-content> patients with clomiphene citrate resistance (group 1) and 28 healthy women as controls (group 2). Baseline serum adiponectin, <jats:styled-content style=\"fixed-case\">AdipoR1<\/jats:styled-content>, total testosterone (<jats:styled-content style=\"fixed-case\">T<\/jats:styled-content>), and homeostasis model of insulin resistance (<jats:styled-content style=\"fixed-case\">HOMA\u2010IR<\/jats:styled-content>) were measured in all participants. Group 1 received metformin (1500\u2009mg\/day) for 6 months followed by second blood sampling.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Group 1 had significantly lower baseline adiponectin and <jats:styled-content style=\"fixed-case\">AdipoR1<\/jats:styled-content> (<jats:italic>P<\/jats:italic>\u2009=\u20090.001) compared to group 2. During treatment, metformin resulted in conception in 5\/68 (7%), ovulation in 33\/68 (48%) and regular cycles in 41\/68 (60%) patients. Group 1 showed post\u2010metformin higher adiponectin and <jats:styled-content style=\"fixed-case\">AdipoR1<\/jats:styled-content> (<jats:italic>P<\/jats:italic>\u2009=\u20090.01) and lower <jats:styled-content style=\"fixed-case\">HOMA\u2010IR<\/jats:styled-content> (<jats:italic>P<\/jats:italic>\u2009=\u20090.006) and <jats:styled-content style=\"fixed-case\">T<\/jats:styled-content> (<jats:italic>P<\/jats:italic>\u2009=\u20090.001) compared to pre\u2010treatment levels. Post\u2010metformin ovulatory patients had higher adiponectin and <jats:styled-content style=\"fixed-case\">AdipoR1<\/jats:styled-content> and lower <jats:styled-content style=\"fixed-case\">HOMA\u2010IR<\/jats:styled-content> and <jats:styled-content style=\"fixed-case\">T<\/jats:styled-content> compared to anovulatory patients. Multivariate regression analysis in group 1 showed that only <jats:styled-content style=\"fixed-case\">T<\/jats:styled-content> and <jats:styled-content style=\"fixed-case\">HOMA\u2010IR<\/jats:styled-content> were significant independent factors for predicting ovulatory cycles during metformin treatment (<jats:italic>P<\/jats:italic>\u2009=\u20090.04 and <jats:italic>P<\/jats:italic>\u2009=\u20090.05, respectively).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Metformin treatment enhances both adiponectin activity and insulin sensitivity, resulting in a less hyperandrogenic state in patients with <jats:styled-content style=\"fixed-case\">PCOS<\/jats:styled-content>. Serum adiponectin and <jats:styled-content style=\"fixed-case\">AdipoR1<\/jats:styled-content> are poor predictors of ovulatory outcome during treatment.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jog.12101","type":"journal-article","created":{"date-parts":[[2013,7,23]],"date-time":"2013-07-23T03:17:11Z","timestamp":1374549431000},"page":"1596-1603","source":"Crossref","is-referenced-by-count":8,"title":["Role of adiponectin and its receptor in prediction of reproductive outcome of metformin treatment in patients with polycystic ovarian syndrome"],"prefix":"10.1111","volume":"39","author":[{"given":"Hossam O.","family":"Hamed","sequence":"first","affiliation":[{"name":"Department of Obstetrics and Gynecology Qassim University  Buraidah City Saudi Arabia"},{"name":"Women's Health Center Assiut University  Assiut 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