{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,29]],"date-time":"2026-10-29T16:42:09Z","timestamp":1793292129369,"version":"4.5.0"},"reference-count":25,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2013,7,22]],"date-time":"2013-07-22T00:00:00Z","timestamp":1374451200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"Tehran University of Medical Sciences, Deputy of Research and Technology","award":["14144"],"award-info":[{"award-number":["14144"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J of Obstet and Gynaecol"],"published-print":{"date-parts":[[2013,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Aim<\/jats:title><jats:p>The purpose of the present study was to evaluate the diagnostic value of maternal serum high\u2010sensitivity <jats:styled-content style=\"fixed-case\">C<\/jats:styled-content>\u2010reactive protein (hs\u2010<jats:styled-content style=\"fixed-case\">CRP<\/jats:styled-content>) measurement during the first trimester of pregnancy for predicting pre\u2010eclampsia.<\/jats:p><\/jats:sec><jats:sec><jats:title>Material and Methods<\/jats:title><jats:p>A prospective cohort study was performed on 394 pregnant women who were at the gestational age of 8\u201313 weeks. In all women, serum hs\u2010<jats:styled-content style=\"fixed-case\">CRP<\/jats:styled-content> was measured by latex agglutination test. The women were then monitored to delivery. We compared the hs\u2010<jats:styled-content style=\"fixed-case\">CRP<\/jats:styled-content> of the two groups, those with and without pre\u2010eclampsia. We used the receiver\u2013operator curve for finding the optimum cut\u2010off points.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Out of 394 women, 42 cases (10.7%) were complicated by pre\u2010eclampsia, of whom 23 women (56.1%) had severe pre\u2010eclampsia. Mean serum hs\u2010<jats:styled-content style=\"fixed-case\">CRP<\/jats:styled-content> of the pre\u2010eclamptic group was higher than that of the normotensive group (7.06\u2009\u00b1\u20092.6\u2009<jats:styled-content style=\"fixed-case\">mg\/L<\/jats:styled-content> vs 3.6\u2009\u00b1\u20092.3\u2009<jats:styled-content style=\"fixed-case\">mg\/L<\/jats:styled-content>, <jats:italic>P<\/jats:italic>\u2009=\u20090.001). The receiver\u2013operator curve showed a significant difference between the under\u2010curve zone for the hs\u2010<jats:styled-content style=\"fixed-case\">CRP<\/jats:styled-content> level with the reference line. Serum hs\u2010<jats:styled-content style=\"fixed-case\">CRP<\/jats:styled-content> of 4\u2009<jats:styled-content style=\"fixed-case\">mg\/L<\/jats:styled-content> showed sensitivity, specificity, positive predictive value, negative predictive value and diagnostic accuracy as 78.1%, 72.1%, 25%, 96.5% and 72.8%, respectively. Hs\u2010CRP of more than 7\u2009<jats:styled-content style=\"fixed-case\">mg\/L<\/jats:styled-content> was found in 26 (61.9%) cases of pre\u2010eclampsia and 22 (6.25%) normotensive pregnancies, which showed a significant difference (<jats:italic>P<\/jats:italic>\u2009=\u20090.001, relative risk\u2009=\u200912.1, 95% confidence interval: 6.91\u201321.15).<\/jats:p><jats:p>Hs\u2010CRP of more than 7\u2009<jats:styled-content style=\"fixed-case\">mg\/L<\/jats:styled-content> was found in 17 (73.91%) cases of severe pre\u2010eclampsia and 22 (6.25%) normotensive pregnancies, which showed a significant difference (<jats:italic>P<\/jats:italic>\u2009=\u20090.001, relative risk\u2009=\u20099.35, 95% confidence interval: 4.48\u201319.52).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p><jats:styled-content style=\"fixed-case\">Hs<\/jats:styled-content>\u2010<jats:styled-content style=\"fixed-case\">CRP<\/jats:styled-content> measurements during the first trimester of pregnancy are helpful in predicting pre\u2010eclampsia.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jog.12105","type":"journal-article","created":{"date-parts":[[2013,7,23]],"date-time":"2013-07-23T03:17:48Z","timestamp":1374549468000},"page":"1549-1554","source":"Crossref","is-referenced-by-count":28,"title":["Evaluation of the diagnostic value of the first\u2010trimester maternal serum high\u2010sensitivity <scp>C<\/scp>\u2010reactive protein level for prediction of pre\u2010eclampsia"],"prefix":"10.1111","volume":"39","author":[{"given":"Maryam","family":"Kashanian","sequence":"first","affiliation":[{"name":"Department of Obstetrics &amp; Gynecology Tehran University of Medical Sciences  Tehran Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Farnaz","family":"Aghbali","sequence":"additional","affiliation":[{"name":"Department of Obstetrics &amp; Gynecology Tehran University of Medical Sciences  Tehran Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Neda","family":"Mahali","sequence":"additional","affiliation":[{"name":"Department of Obstetrics &amp; Gynecology Tehran University of Medical Sciences  Tehran Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2013,7,22]]},"reference":[{"key":"e_1_2_7_2_1","first-page":"706","volume-title":"Williams Obstetrics","author":"Cunninghan FG","year":"2010"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1179\/acb.2010.001"},{"key":"e_1_2_7_4_1","first-page":"145","volume-title":"Chesley's Hypertensive Disorders in Pregnancy","author":"Taylor RN","year":"2009"},{"key":"e_1_2_7_5_1","first-page":"722","article-title":"Phenotypic and metabolic characteristics of monocytes and granulocytes in pre\u2010eclampsia","volume":"185","author":"Gervasi MT","year":"2001","journal-title":"Am J Obstet Gynecol"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-9378(00)70223-7"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1038\/ajh.2009.54"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.placenta.2005.05.009"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1080\/10641950701885188"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1097\/HJH.0b013e3281139ea9"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejogrb.2005.05.007"},{"key":"e_1_2_7_12_1","first-page":"1019","article-title":"C\u2010reactive protein, marker for evaluation of systemic inflammatory response in pre\u2010eclampsia","volume":"112","author":"Mihu D","year":"2008","journal-title":"Rev Med Chir Soc Med Nat Lasi"},{"key":"e_1_2_7_13_1","first-page":"209","article-title":"Relationships of serum level of high\u2010sensitivity C\u2010reactive protein (hs\u2010 CRP) and white blood cell (WBC) count with gamma glutamyltransferase among Iranian healthy adults","volume":"7","author":"Abdollahi A","year":"2012","journal-title":"Iran J Pathol"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijgo.2007.03.050"},{"key":"e_1_2_7_15_1","doi-asserted-by":"publisher","DOI":"10.3310\/hta12060"},{"key":"e_1_2_7_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1701-2163(16)32973-5"},{"key":"e_1_2_7_17_1","doi-asserted-by":"publisher","DOI":"10.1002\/jcu.20781"},{"key":"e_1_2_7_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejogrb.2004.12.009"},{"key":"e_1_2_7_19_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1447-0756.2010.01279.x"},{"key":"e_1_2_7_20_1","doi-asserted-by":"publisher","DOI":"10.1080\/10641950802601187"},{"key":"e_1_2_7_21_1","doi-asserted-by":"publisher","DOI":"10.1080\/10641950802601179"},{"key":"e_1_2_7_22_1","doi-asserted-by":"publisher","DOI":"10.3109\/10641950903214633"},{"key":"e_1_2_7_23_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0165-0378(02)00085-2"},{"key":"e_1_2_7_24_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1471-0528.2002.01130.x"},{"key":"e_1_2_7_25_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.amjhyper.2003.09.011"},{"key":"e_1_2_7_26_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1447-0756.2008.00835.x"}],"container-title":["Journal of Obstetrics and Gynaecology Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fjog.12105","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fjog.12105","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/obgyn.onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/jog.12105","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,1]],"date-time":"2023-10-01T14:51:28Z","timestamp":1696171888000},"score":1,"resource":{"primary":{"URL":"https:\/\/obgyn.onlinelibrary.wiley.com\/doi\/10.1111\/jog.12105"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2013,7,22]]},"references-count":25,"journal-issue":{"issue":"12","published-print":{"date-parts":[[2013,12]]}},"alternative-id":["10.1111\/jog.12105"],"URL":"https:\/\/doi.org\/10.1111\/jog.12105","archive":["Portico"],"relation":{},"ISSN":["1341-8076","1447-0756"],"issn-type":[{"value":"1341-8076","type":"print"},{"value":"1447-0756","type":"electronic"}],"subject":[],"published":{"date-parts":[[2013,7,22]]}}}