{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2023,10,2]],"date-time":"2023-10-02T05:45:54Z","timestamp":1696225554688},"reference-count":13,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2013,7,22]],"date-time":"2013-07-22T00:00:00Z","timestamp":1374451200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J of Obstet and Gynaecol"],"published-print":{"date-parts":[[2013,12]]},"abstract":"Abstract<\/jats:title>Aim<\/jats:title>Tubal ectopic pregnancy (tEP<\/jats:styled-content>) must be diagnosed as early as possible because it is one of the leading causes of pregnancy\u2010related death in the first trimester. The aim of this study was to evaluate the diagnostic value of serum total creatine kinase (CK<\/jats:styled-content>) and its isoforms in diagnosis of tEP<\/jats:styled-content>.<\/jats:p><\/jats:sec>Methods<\/jats:title>The study included 32 tEP<\/jats:styled-content> cases, and gestational age\u2010matched intrauterine (IU<\/jats:styled-content>) abortion and normal pregnancy cases (n<\/jats:italic>\u2009=\u200931 each). Serum total CK<\/jats:styled-content> and CK\u2010MB<\/jats:styled-content> fraction were measured by the principle of spectrophotometry and CK\u2010MM<\/jats:styled-content> fraction was calculated from the above parameters. Serum \u03b2\u2010hCG<\/jats:styled-content> was measured using chemiluminescent immunoassay. All study parameters were measured at the time of presentation.<\/jats:p><\/jats:sec>Results<\/jats:title>Serum \u03b2\u2010hCG<\/jats:styled-content> levels were significantly low in patients with both tEP<\/jats:styled-content> and IU<\/jats:styled-content> abortion than normal pregnancy. Women with tEP<\/jats:styled-content> had higher concentrations of total CK<\/jats:styled-content>, CK\u2010MM<\/jats:styled-content> and lower concentrations of CK\u2010MB<\/jats:styled-content>% compared to both gestational age\u2010matched IU<\/jats:styled-content> pregnancy controls and IU<\/jats:styled-content> abortion. Receiver\u2013operator characteristic analysis revealed that the optimal cut\u2010off for total CK<\/jats:styled-content>, CK\u2010MM<\/jats:styled-content> and CPK\u2010MB<\/jats:styled-content>% as predictors of ruptured EP<\/jats:styled-content> were 147\u2009IU\/L<\/jats:styled-content>, 135\u2009IU\/L<\/jats:styled-content> and 10%, respectively, with the former two having higher specificity, and latter high sensitivity.<\/jats:p><\/jats:sec>Conclusion<\/jats:title>Estimation of CK<\/jats:styled-content> and its CK<\/jats:styled-content> isoenzyme fractions can aid in quick and accurate diagnosis of tEP<\/jats:styled-content>.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jog.12109","type":"journal-article","created":{"date-parts":[[2013,7,23]],"date-time":"2013-07-23T04:44:13Z","timestamp":1374554653000},"page":"1587-1591","source":"Crossref","is-referenced-by-count":1,"title":["Diagnostic significance of total creatine kinase and its isoform in tubal ectopic pregnancy"],"prefix":"10.1111","volume":"39","author":[{"given":"Rajendiran","family":"Soundravally","sequence":"first","affiliation":[{"name":"Department of Biochemistry Jawaharlal Institute of Post\u2010graduate Medical Education and Research Puducherry India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Thammineni","family":"Krishna Latha","sequence":"additional","affiliation":[{"name":"Department of Biochemistry Jawaharlal Institute of Post\u2010graduate Medical Education and Research Puducherry India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Subrahmanian","family":"Soundara Raghavan","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynaecology Jawaharlal Institute of Post\u2010graduate Medical Education and Research Puducherry India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Palghat Hariharan","family":"Ananthanarayanan","sequence":"additional","affiliation":[{"name":"Department of Biochemistry Jawaharlal Institute of Post\u2010graduate Medical Education and Research Puducherry India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Krishnamoorthy","family":"Srilatha","sequence":"additional","affiliation":[{"name":"Department of Biochemistry Jawaharlal Institute of Post\u2010graduate Medical Education and Research Puducherry India"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2013,7,22]]},"reference":[{"key":"e_1_2_6_2_1","first-page":"49","article-title":"Ectopic pregnancy early diagnosis markers","volume":"62","author":"Segal S","year":"2010","journal-title":"Minerva 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