{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,1]],"date-time":"2026-06-01T20:06:08Z","timestamp":1780344368361,"version":"3.54.1"},"reference-count":17,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2013,8,12]],"date-time":"2013-08-12T00:00:00Z","timestamp":1376265600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J of Obstet and Gynaecol"],"published-print":{"date-parts":[[2014,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Aim<\/jats:title><jats:p>The human embryo\u2013maternal interface in the first trimester of pregnancy is an area of extensive tissue remodeling. Because collagen is the most abundant constituent of the extracellular matrix of the placental bed, successful invasion must involve its rapid turnover. We compared the nature and distribution of collagen fibrils in decidua basalis and parietalis.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We used a direct\u2010vision hysteroscopic technique to obtain biopsies of the decidua basalis and parietalis from 11 women undergoing pregnancy termination in the first trimester. The biopsies were subjected to light, transmission and scanning electron microscopy, and immunohistochemical studies using mouse monoclonal antibodies against cytokeratin 7 and collagen types <jats:styled-content style=\"fixed-case\">I<\/jats:styled-content>, <jats:styled-content style=\"fixed-case\">III<\/jats:styled-content> and <jats:styled-content style=\"fixed-case\">V<\/jats:styled-content>.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Collagen fibrils in the stroma of decidua basalis were significantly thicker when compared to those in decidua parietalis (56.48\u2009\u00b1\u20091.37\u2009nm vs 45.64\u2009\u00b1\u20090.85\u2009nm; <jats:italic>P<\/jats:italic>\u2009&lt;\u20090.0001 [mean\u2009\u00b1\u2009standard error]) between 9 and 12\u2009weeks gestation, but this difference in thickness was not observed at gestations below 9 weeks. In basalis, the fibrils appeared disrupted at most places surrounding the decidual\/trophoblast cells while a uniform regular arrangement was preserved throughout most of parietalis.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>There are differences in the ultrastructure of collagen fibrils between basalis and parietalis, with thicker and disrupted fibrils within abundant amorphous tissue in basalis, and thinner uniform fibrils in parietalis. These differences may reflect an adaptive response by decidua or a direct consequence of the invading trophoblast cells.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jog.12127","type":"journal-article","created":{"date-parts":[[2013,8,13]],"date-time":"2013-08-13T04:40:42Z","timestamp":1376368842000},"page":"80-88","source":"Crossref","is-referenced-by-count":10,"title":["Differences in collagen ultrastructure of human first trimester decidua basalis and parietalis: Implications for trophoblastic invasion of the placental bed"],"prefix":"10.1111","volume":"40","author":[{"given":"Vikram","family":"Sinai Talaulikar","sequence":"first","affiliation":[{"name":"Department of Obstetrics and Gynaecology Division of Clinical Sciences St George's University of London  London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Katrin","family":"Kronenberger","sequence":"additional","affiliation":[{"name":"Electron Microscopy Unit St George's University of London  London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bridget E.","family":"Bax","sequence":"additional","affiliation":[{"name":"Department of Child Health, Division of Clinical Sciences St George's University of London  London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Raymond","family":"Moss","sequence":"additional","affiliation":[{"name":"Electron Microscopy Unit St George's University of London  London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Isaac","family":"Manyonda","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynaecology Division of Clinical Sciences St George's University of London  London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2013,8,12]]},"reference":[{"key":"e_1_2_5_2_1","doi-asserted-by":"publisher","DOI":"10.1096\/fasebj.7.9.8330681"},{"key":"e_1_2_5_3_1","first-page":"519","article-title":"Extracellular matrix\u2010cell interactions: Dynamic modulators of cell, tissue and organism structure and function","volume":"66","author":"Madri JA","year":"1992","journal-title":"Lab Invest"},{"key":"e_1_2_5_4_1","first-page":"369","article-title":"Extracellular matrix and growth factors: An integrated interplay controlling tissue repair and progression to disease","volume":"69","author":"Haralson MA","year":"1993","journal-title":"Lab Invest"},{"key":"e_1_2_5_5_1","doi-asserted-by":"publisher","DOI":"10.1093\/humupd\/2.4.307"},{"key":"e_1_2_5_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.placenta.2012.02.018"},{"key":"e_1_2_5_7_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF00219220"},{"key":"e_1_2_5_8_1","doi-asserted-by":"publisher","DOI":"10.1002\/aja.1001860411"},{"key":"e_1_2_5_9_1","doi-asserted-by":"publisher","DOI":"10.1002\/jemt.20265"},{"key":"e_1_2_5_10_1","doi-asserted-by":"publisher","DOI":"10.1002\/ar.1092180408"},{"key":"e_1_2_5_11_1","doi-asserted-by":"publisher","DOI":"10.1002\/jemt.20381"},{"key":"e_1_2_5_12_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF00221758"},{"key":"e_1_2_5_13_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.81.9.2791"},{"key":"e_1_2_5_14_1","doi-asserted-by":"publisher","DOI":"10.1002\/aja.1001720102"},{"key":"e_1_2_5_15_1","doi-asserted-by":"crossref","first-page":"261","DOI":"10.32604\/biocell.2005.29.261","article-title":"Extracellular breakdown of collagen by mice decidual cells. 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