{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,30]],"date-time":"2026-01-30T03:08:03Z","timestamp":1769742483346,"version":"3.49.0"},"reference-count":26,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2013,10,7]],"date-time":"2013-10-07T00:00:00Z","timestamp":1381104000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J of Obstet and Gynaecol"],"published-print":{"date-parts":[[2014,2]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Aim<\/jats:title><jats:p>To investigate whether there is difference in trophoblast apoptosis between infants with asymmetrical idiopathic intrauterine growth retardation (<jats:styled-content style=\"fixed-case\">IUGR<\/jats:styled-content>) and those with symmetrical fetal growth appropriate for gestational age (<jats:styled-content style=\"fixed-case\">AGA<\/jats:styled-content>).<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Data and placentas from 52 singleton term pregnancies with idiopathic <jats:styled-content style=\"fixed-case\">IUGR<\/jats:styled-content>, from which a subgroup of 33 (63.4%) infants with asymmetrical growth and malnutrition was identified using the ponderal index served as a study group. The control group included 60 (86.9%) infants with symmetrical growth, identified by the same criterion among 69 normal singleton pregnancies with <jats:styled-content style=\"fixed-case\">AGA<\/jats:styled-content>. <jats:styled-content style=\"fixed-case\">IUGR<\/jats:styled-content> was defined by birthweight less than the 10th percentile of standard values. Ponderal index value was considered as the measurement of fetal growth proportionality.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The proportion of fetal thinness up to ponderal index value was greater in the <jats:styled-content style=\"fixed-case\">IUGR<\/jats:styled-content> group than control (\u03c7<jats:sup>2<\/jats:sup>\u2009=\u20099.2; <jats:italic>P<\/jats:italic>\u2009=\u20090.002). There was no statistically significant difference in the cytotrophoblast proliferation (<jats:italic>t<\/jats:italic>\u2009=\u20090.88; <jats:italic>P<\/jats:italic>\u2009=\u20090.373), trophoblast expression of the <jats:styled-content style=\"fixed-case\">B<\/jats:styled-content>cl\u20102 anti\u2010apoptotic factor (z\u2009=\u20090.66; <jats:italic>P<\/jats:italic>\u2009=\u20090.505), total trophoblast apoptotic index (<jats:italic>t<\/jats:italic>\u2009=\u20090.45; <jats:italic>P<\/jats:italic>\u2009=\u20090.651), as in cytotrophoblast (t\u2009=\u20090.01; <jats:italic>P<\/jats:italic>\u2009=\u20090.988) and syncytiotrophoblast apoptotic index (<jats:italic>t<\/jats:italic>\u2009=\u20090.34; <jats:italic>P<\/jats:italic>\u2009=\u20090.730) between the idiopathic asymmetrical <jats:styled-content style=\"fixed-case\">IUGR<\/jats:styled-content> and control group.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Asymmetry of fetal growth is a result of rather long\u2010term placental nutritive insufficiency in which trophoblasts have a central role. Although being crucial for its functioning, the proliferative and apoptotic trophoblast activity remains unaltered in the placentas from pregnancies with idiopathic <jats:styled-content style=\"fixed-case\">IUGR<\/jats:styled-content> and asymmetrical fetal growth. The results obtained in this study indicate that placental nutritive insufficiency may develop without any deviation in the physiological trophoblast regeneration via apoptosis.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jog.12170","type":"journal-article","created":{"date-parts":[[2013,10,12]],"date-time":"2013-10-12T02:39:45Z","timestamp":1381545585000},"page":"410-417","source":"Crossref","is-referenced-by-count":6,"title":["Asymmetrical fetal growth is not associated with altered trophoblast apoptotic activity in idiopathic intrauterine growth retardation"],"prefix":"10.1111","volume":"40","author":[{"given":"Damir","family":"Roje","sequence":"first","affiliation":[{"name":"Clinical Hospital Center Split  Split Croatia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sandra","family":"Zekic Tomas","sequence":"additional","affiliation":[{"name":"Clinical Hospital Center Split  Split Croatia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Vesna","family":"Capkun","sequence":"additional","affiliation":[{"name":"Clinical Hospital Center Split  Split Croatia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jelena","family":"Marusic","sequence":"additional","affiliation":[{"name":"Clinical Hospital Center Split  Split Croatia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jasminka","family":"Resic","sequence":"additional","affiliation":[{"name":"Clinical Hospital Center Split  Split Croatia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ivana","family":"Kuzmic Prusac","sequence":"additional","affiliation":[{"name":"Clinical Hospital Center Split  Split Croatia"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2013,10,7]]},"reference":[{"key":"e_1_2_5_2_1","doi-asserted-by":"publisher","DOI":"10.1097\/00003081-200606000-00005"},{"key":"e_1_2_5_3_1","first-page":"1171","volume-title":"Textbook of Perinatal Medicine","author":"Carrera JM","year":"1998"},{"key":"e_1_2_5_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajog.2005.07.039"},{"key":"e_1_2_5_5_1","doi-asserted-by":"publisher","DOI":"10.1210\/er.2005-0003"},{"key":"e_1_2_5_6_1","first-page":"103","article-title":"Placental villous trophoblast: the altered balance between proliferation and apoptosis triggers pre\u2010eclampsia","volume":"3","author":"Huppertz B","year":"2006","journal-title":"J Reproduktionsmed Endocrinol"},{"key":"e_1_2_5_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.placenta.2007.01.016"},{"key":"e_1_2_5_8_1","doi-asserted-by":"publisher","DOI":"10.1159\/000320289"},{"key":"e_1_2_5_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0020-7292(01)00373-3"},{"key":"e_1_2_5_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jri.2003.10.001"},{"key":"e_1_2_5_11_1","doi-asserted-by":"publisher","DOI":"10.3109\/14767058.2010.526158"},{"key":"e_1_2_5_12_1","first-page":"66","article-title":"Birth weights and birth lengths of newborns from the town of Split; 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