{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,24]],"date-time":"2026-03-24T01:00:53Z","timestamp":1774314053109,"version":"3.50.1"},"reference-count":36,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2013,10,7]],"date-time":"2013-10-07T00:00:00Z","timestamp":1381104000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J of Obstet and Gynaecol"],"published-print":{"date-parts":[[2014,2]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Aim<\/jats:title><jats:p>We aim to evaluate the effect of <jats:italic><jats:styled-content style=\"fixed-case\">N<\/jats:styled-content>igella sativa<\/jats:italic> oil (<jats:styled-content style=\"fixed-case\">NSO<\/jats:styled-content>) on postoperative peritoneal adhesion formation in female rats. This experimental study is the first on the prevention of postoperative adhesion formation by <jats:styled-content style=\"fixed-case\">NSO<\/jats:styled-content>.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Twenty\u2010four <jats:styled-content style=\"fixed-case\">W<\/jats:styled-content>istar albino female rats were randomly assigned to three groups of eight rats each. <jats:styled-content style=\"fixed-case\">R<\/jats:styled-content>ats in group 1 were each injected i.p. with 1\u2009mL of <jats:styled-content style=\"fixed-case\">NSO<\/jats:styled-content>. In group 2, an adhesion model was created with no injection of <jats:styled-content style=\"fixed-case\">NSO<\/jats:styled-content>. In group 3, an adhesion model was created and the area was covered with 1\u2009mL of <jats:styled-content style=\"fixed-case\">NSO<\/jats:styled-content>. The rats were killed on postoperative day 8, and the severity of adhesions was evaluated macroscopically and histopathologically.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>There was a statistically significant difference in adhesion scores between group 2 (control) and group 3 (<jats:styled-content style=\"fixed-case\">NSO<\/jats:styled-content>\u2010treated) (<jats:italic>P<\/jats:italic>\u2009<jats:italic>=<\/jats:italic>\u20090.003). Statistically significant differences in angiogenesis, fibrosis and inflammation were observed between the control and <jats:italic><jats:styled-content style=\"fixed-case\">N<\/jats:styled-content>igella sativa<\/jats:italic> groups (<jats:italic>P<\/jats:italic>\u2009=\u20090.002, <jats:italic>P<\/jats:italic>\u2009=\u20090.001 and <jats:italic>P<\/jats:italic>\u2009=\u20090.004, respectively).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Covering peritoneal surfaces with <jats:styled-content style=\"fixed-case\">NSO<\/jats:styled-content> after peritoneal trauma is effective in decreasing peritoneal adhesion formation.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jog.12172","type":"journal-article","created":{"date-parts":[[2013,10,9]],"date-time":"2013-10-09T08:48:01Z","timestamp":1381308481000},"page":"532-537","source":"Crossref","is-referenced-by-count":6,"title":["Effect of <i><scp>N<\/scp>igella sativa<\/i> oil on postoperative peritoneal adhesion formation"],"prefix":"10.1111","volume":"40","author":[{"given":"Ahmet","family":"Sahbaz","sequence":"first","affiliation":[{"name":"School of Medicine Department of Obstetrics and Gynecology Bulent Ecevit University  Kozlu\/Zonguldak Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Firat","family":"Ersan","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology Kanuni Sultan Suleyman Research and Training Hospital  Istanbul Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Serdar","family":"Aydin","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology Kanuni Sultan Suleyman Research and Training Hospital  Istanbul Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2013,10,7]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(98)09337-4"},{"key":"e_1_2_6_3_1","first-page":"1877","article-title":"The impact of adhesions on hospital readmissions over ten years after 8849 open gynecologic operations: An assessment from Surgical and Clinical Adhesion Research Study","volume":"19","author":"Lower AM","year":"2000","journal-title":"BJOG"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.sla.0000225097.60142.68"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1093\/humrep\/deh321"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1072-7515(97)00127-0"},{"key":"e_1_2_6_7_1","first-page":"222","article-title":"Are pelvic adhesions preventable?","volume":"11","author":"El\u2010Mowafi DM","year":"2003","journal-title":"Surg Technol Int"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jss.2005.12.002"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1074-3804(05)60041-2"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-9610(02)00876-0"},{"key":"e_1_2_6_11_1","doi-asserted-by":"publisher","DOI":"10.1080\/00015458.2003.11978403"},{"key":"e_1_2_6_12_1","doi-asserted-by":"publisher","DOI":"10.1093\/humrep\/16.8.1732"},{"key":"e_1_2_6_13_1","first-page":"39","article-title":"Oxygen free radicals and pelvic adhesion formation: I. Blocking oxygen free radical toxicity to prevent adhesion formation in an endometriosis model","volume":"36","author":"Portz DM","year":"1991","journal-title":"Int J Fertil"},{"key":"e_1_2_6_14_1","doi-asserted-by":"publisher","DOI":"10.1093\/humrep\/deg337"},{"key":"e_1_2_6_15_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10350-004-0741-6"},{"key":"e_1_2_6_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0015-0282(00)00656-7"},{"key":"e_1_2_6_17_1","doi-asserted-by":"publisher","DOI":"10.1080\/01443610063543"},{"key":"e_1_2_6_18_1","doi-asserted-by":"publisher","DOI":"10.1093\/humrep\/15.6.1358"},{"key":"e_1_2_6_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0015-0282(00)01677-0"},{"key":"e_1_2_6_20_1","doi-asserted-by":"publisher","DOI":"10.1002\/ptr.1309"},{"key":"e_1_2_6_21_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10787-999-0023-y"},{"key":"e_1_2_6_22_1","first-page":"495","article-title":"From here to eternity\u2010the secret of Pharaohs: Therapeutic potential of black cumin seeds and beyond","volume":"6","author":"Pahdhye S","year":"2008","journal-title":"Cancer Ther"},{"key":"e_1_2_6_23_1","doi-asserted-by":"publisher","DOI":"10.1002\/bjs.1800610406"},{"key":"e_1_2_6_24_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0015-0282(16)47909-4"},{"key":"e_1_2_6_25_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-9610(05)80516-1"},{"key":"e_1_2_6_26_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0039-6060(99)70267-9"},{"key":"e_1_2_6_27_1","first-page":"13","article-title":"Effects of leukocytes adhesion and microvascular permeability, capillary perfusion during ischemia reperfusion injury in hamster check pouch","volume":"13","author":"Bertuglia S","year":"1993","journal-title":"Int J Microcirc Clin Exp"},{"key":"e_1_2_6_28_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.intimp.2005.06.008"},{"key":"e_1_2_6_29_1","doi-asserted-by":"publisher","DOI":"10.1081\/DCT-120020404"},{"key":"e_1_2_6_30_1","doi-asserted-by":"crossref","first-page":"251","DOI":"10.1093\/oxfordjournals.humrep.a137316","article-title":"The effect of prostaglandins and aspirin\u2010an inhibitor of prostaglandin synthesis\u2010on adhesion formation in rats","volume":"6","author":"Golan A","year":"1991","journal-title":"Hum Reprod"},{"key":"e_1_2_6_31_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.sla.0000167847.53159.c1"},{"key":"e_1_2_6_32_1","doi-asserted-by":"publisher","DOI":"10.3109\/08941939409015369"},{"key":"e_1_2_6_33_1","first-page":"315","article-title":"Inhibition of postsurgical adhesions by liposomes containing nonsteroidal anti\u2010inflammatory drugs","volume":"35","author":"Rodgers K","year":"1990","journal-title":"Int J Fertil"},{"key":"e_1_2_6_34_1","doi-asserted-by":"crossref","first-page":"112","DOI":"10.1007\/s00423-003-0369-3","article-title":"Orally delivered antibiotics which lower bacterial numbers decrease experimental intra\u2010abdominal adhesions","volume":"388","author":"Bothin C","year":"2003","journal-title":"Langenbecks Arch Surg"},{"key":"e_1_2_6_35_1","first-page":"160","article-title":"Synergic effect of Dextran 70 at 32% and an antibiotic in the prevention of peritoneal adhesions. Experimental study in rats]","volume":"129","author":"Boudouris O","year":"1992","journal-title":"J Chir (Paris)"},{"key":"e_1_2_6_36_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0192-0561(00)00036-9"},{"key":"e_1_2_6_37_1","doi-asserted-by":"publisher","DOI":"10.1016\/0378-8741(91)90047-H"}],"container-title":["Journal of Obstetrics and Gynaecology Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fjog.12172","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fjog.12172","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/obgyn.onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/jog.12172","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,10,22]],"date-time":"2024-10-22T12:47:20Z","timestamp":1729601240000},"score":1,"resource":{"primary":{"URL":"https:\/\/obgyn.onlinelibrary.wiley.com\/doi\/10.1111\/jog.12172"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2013,10,7]]},"references-count":36,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2014,2]]}},"alternative-id":["10.1111\/jog.12172"],"URL":"https:\/\/doi.org\/10.1111\/jog.12172","archive":["Portico"],"relation":{},"ISSN":["1341-8076","1447-0756"],"issn-type":[{"value":"1341-8076","type":"print"},{"value":"1447-0756","type":"electronic"}],"subject":[],"published":{"date-parts":[[2013,10,7]]}}}